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Porcine-Derived Chondroitin Sulfate Sodium Alleviates Osteoarthritis in HTB-94 Cells and MIA-Induced SD Rat Models. [PDF]
Int J Mol SciKim H +6 more
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Glucosamine and Chondroitin Sulfate [PDF]
Rheumatic Disease Clinics of North America, 2011 Glucosamine and chondroitin sulfate, components of normal cartilage that are marketed as dietary supplements in the United States, have been evaluated for their potential role in the treatment of osteoarthritis. Due to claims of efficacy, increased prevalence of osteoarthritis, and a lack of other effective therapies, there has been substantial ...
Daniel O. Clegg +2 more
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Production of chondroitin sulfate and chondroitin
Applied Microbiology and Biotechnology, 2010The production of microbial polysaccharides has recently gained much interest because of their potential biotechnological applications. Several pathogenic bacteria are known to produce capsular polysaccharides, which provide a protection barrier towards harsh environmental conditions, and towards host defences in case of invasive infections.
SCHIRALDI, Chiara +2 more
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Journal of Molecular Structure: THEOCHEM, 2004
Abstract Molecular modeling of glycosaminoglycans, hyaluronan, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate and keratan sulfate is presented. Semiempirical quantum mechanical calculations, PM3 method, have been used to locate the minimal energy regions in the conformational space around the β 1→3 and β 1→4 glycosidic linkages. The global
Tereza Varnali +3 more
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Abstract Molecular modeling of glycosaminoglycans, hyaluronan, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate and keratan sulfate is presented. Semiempirical quantum mechanical calculations, PM3 method, have been used to locate the minimal energy regions in the conformational space around the β 1→3 and β 1→4 glycosidic linkages. The global
Tereza Varnali +3 more
openaire +2 more sources
The biosynthesis of chondroitin sulfate
Archives of Biochemistry and Biophysics, 1966Abstract A particulate enzyme preparation from embryonic chick cartilage catalyzes incorporation of radioactivity from UDP-GalNAc- 3 H or UDP-Glc-UA- 14 C into chondroitin sulfate. In the absence of added oligosaccharide acceptor, incorporation of radioactivity from either nucleotide required the presence of the alternate unlabeled nucleotide ...
Alvin Telser +2 more
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Matrix, 1993
Monoclonal antibodies have been developed that recognize epitopes in native chondroitin sulfate chains. One of these antibodies, CS-56, reportedly recognizes chondroitin 4- and 6-sulfates. However, this antibody, and four other anti-chondroitin sulfate antibodies, 4C3, 4D3, 6C3 and 7D4, do not recognize epitopes in chondroitin sulfate chains from Swarm
David A. Carrino +2 more
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Monoclonal antibodies have been developed that recognize epitopes in native chondroitin sulfate chains. One of these antibodies, CS-56, reportedly recognizes chondroitin 4- and 6-sulfates. However, this antibody, and four other anti-chondroitin sulfate antibodies, 4C3, 4D3, 6C3 and 7D4, do not recognize epitopes in chondroitin sulfate chains from Swarm
David A. Carrino +2 more
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Structure of Chondroitin Sulfate
2006Publisher Summary This chapter presents the up‐to‐date information on the structure of chondroitin sulfate (CS) and dermatan sulfate (DS). CS is an anionic linear polysaccharide, which is synthesized as part of proteoglycan (PG) molecules in vertebrates and invertebrates.
Nikos K. Karamanos, Fotini N. Lamari
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Stability studies of chondroitin sulfate
Carbohydrate Research, 1999The stability of chondroitin sulfate (CS) was studied under acidic, neutral and basic conditions at 30 and 60 degrees C. CS is remarkably stable under neutral conditions at low temperature, while it degrades at 60 degrees C producing low-molecular-mass fragments and desulfated products. This decomposition process begins at ca.
VOLPI, Nicola +2 more
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Biosynthesis and function of chondroitin sulfate
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular and extracellular components that form regulatory milieu involving numerous biological and pathophysiological phenomena. Diverse functions of CSPGs can be mainly attributed to structural variability of their polysaccharide moieties, chondroitin sulfate glycosaminoglycans (CS-GAG ...
Hiroshi Kitagawa, Tadahisa Mikami
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Calcium binding by chondroitin sulfate
Calcified Tissue Research, 1968The binding of calcium by chondroitin sulfate C was studied by employing biological and physicochemical methods for the quantitative determination of ionic calcium. Mean values for logKj, the logarithm of the uncorrected formation constant for a calcium-chondroitin sulfate complex, were 1.64 with the frog heart technique, 1.55 with the murexide method,
Basil S. Strates +3 more
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