Results 1 to 10 of about 84,285 (265)

Neuroendocrine tumors show altered expression of chondroitin sulfate, glypican 1, glypican 5 and syndecan 2 depending on their differentiation grade

Frontiers in Oncology, 2014
Neuroendocrine tumors are found throughout the body and are important as they give rise to distinct clinical syndromes. Glycosaminoglycans, in proteoglycan form or as free chains, play vital roles in every step of tumor progression.
Olivia eGarcía-Suárez, Beatriz eGarcía, Iván eFernández-Vega, Aurora eAstudillo, Aurora eAstudillo, Luis M Quirós, Luis M Quirós   +6 more
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Proteoglycans as Therapeutic Targets in Brain Cancer

Frontiers in Oncology, 2020
Proteoglycans (PGs) are heavily glycosylated diverse proteins consisting of a “core protein” covalently attached to glycosaminoglycans (GAGs) and present on the cell surface, extracellular matrix, and intracellular milieu.
Zoya Yan, Shanzhi Wang
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Syndecan-4 Modulates Cell Polarity and Migration by Influencing Centrosome Positioning and Intracellular Calcium Distribution

Frontiers in Cell and Developmental Biology, 2020
Efficient cell migration requires cellular polarization, which is characterized by the formation of leading and trailing edges, appropriate positioning of the nucleus and reorientation of the Golgi apparatus and centrosomes toward the leading edge ...
Daniel Becsky, Kitti Szabo, Szuzina Gyulai-Nagy, Tamas Gajdos, Zsuzsa Bartos, Arpad Balind, Laszlo Dux, Peter Horvath, Miklos Erdelyi, Laszlo Homolya, Aniko Keller-Pinter   +10 more
doaj   +1 more source

Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response

Cell Structure and Function
The Golgi stress response is a homeostatic mechanism that augments Golgi function when Golgi function becomes insufficient (Golgi stress). Glycosylation of the core proteins of proteoglycans is one of the important functions of the Golgi.
Kanae Sasaki, Reishi Tanaka, Iona Miyake, Miyu Sakamoto, Ryuya Tanaka, Azusa Tanaka, Misaki Terami, Ryota Komori, Mai Taniguchi, Sadao Wakabayashi, Hajime Tajima Sakurai, Hiderou Yoshida   +11 more
doaj   +1 more source

Structure-Activity Relationships of Bioengineered Heparin/Heparan Sulfates Produced in Different Bioreactors

Molecules, 2017
Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine.
Ha Na Kim, John M. Whitelock, Megan S. Lord   +2 more
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Structural Variation of Chondroitin Sulfate Chains Contributes to the Molecular Heterogeneity of Perineuronal Nets

Frontiers in Integrative Neuroscience, 2018
Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath parvalbumin-expressing inhibitory neurons (parvalbumin, PV cells) late in brain ...
Shinji Miyata, Satomi Nadanaka, Michihiro Igarashi, Hiroshi Kitagawa   +3 more
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Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis [PDF]

European Cells & Materials, 2007
Magnetic resonance imaging of articular cartilage has recently been recognized as a tool for the characterization of cartilage morphology, biochemistry and function.
G Blumenkrantz, S Majumdar
doaj  

Serum decorin and biglycan levels as predictive biomarkers for lung fibrosis severity and mortality risk in COVID-19 patients

Frontiers in Medicine
IntroductionIndividuals experiencing severe symptoms of COVID-19 are at the greatest risk of developing post-COVID lung fibrosis, which significantly impacts long-term health outcomes.
Shaaf Ahmad, Kaleem Maqsood, Farwa Liaqat, Nabila Roohi   +3 more
doaj   +1 more source

Biology and Biomechanics of the Heart Valve Extracellular Matrix

Journal of Cardiovascular Development and Disease, 2020
Heart valves are dynamic structures that, in the average human, open and close over 100,000 times per day, and 3 × 109 times per lifetime to maintain unidirectional blood flow.
Karthik M. Kodigepalli, Kaitlyn Thatcher, Toni West, Daniel P. Howsmon, Frederick J. Schoen, Michael S. Sacks, Christopher K. Breuer, Joy Lincoln   +7 more
doaj   +1 more source

The Effect of Geranium Leaf Essential oil Pelargonium graveolens on the Expression of MMPs, IL-1β, NO, and PGE2 in Collagenase-induced Arthritis in Rabbits [PDF]

Armaghane Danesh Bimonthly Journal
Background & aim: Chronic diseases, including osteoarthritis, are often debilitating due to their progressive course and affect the quality of life of the elderly.
H Maghsoudi, F Jola, GH Bakhshi Khanegi
doaj