Results 1 to 10 of about 41,007 (163)

Heparan sulfates and heparan sulfate binding proteins in sepsis

Frontiers in Molecular Biosciences, 2023
Heparan sulfates (HSs) are the main components in the glycocalyx which covers endothelial cells and modulates vascular homeostasis through interactions with multiple Heparan sulfate binding proteins (HSBPs).
Yi-En Liao, Jian Liu, Katelyn Arnold
doaj   +3 more sources

Heparan Sulfate Proteoglycans in Tauopathy

Biomolecules, 2022
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu, Lauren Gandy, Fuming Zhang, Jian Liu, Chunyu Wang, Laura J. Blair, Robert J. Linhardt, Lianchun Wang   +7 more
doaj   +3 more sources

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression [PDF]

Frontiers in Endocrinology, 2018
Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate
Arvindhan Nagarajan, Parmanand Malvi, Narendra Wajapeyee, Narendra Wajapeyee   +3 more
doaj   +3 more sources

Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2 [PDF]

mBio
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants have acquired enhanced infectivity compared to earlier variants. To elucidate the underlying molecular mechanisms, we conducted CRISPR library screening to identify cell ...
Shuhei Higuchi, Yafei Liu, Jun Shimizu, Chikako Ono, Yumi Itoh, Wataru Nakai, Hui Jin, Kazuki Kishida, Kazuo Takayama, Toru Okamoto, Yoshiko Murakami, Taroh Kinoshita, Yoshiharu Matsuura, Tatsuo Shioda, Hisashi Arase   +14 more
doaj   +2 more sources

Heparan sulfate and cell division [PDF]

Brazilian Journal of Medical and Biological Research, 1999
Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic ...
Porcionatto M.A., Nader H.B., Dietrich C.P.   +2 more
doaj   +6 more sources

Interactions of proteins with heparan sulfate. [PDF]

Essays Biochem
Abstract Heparan sulfate (HS) is a glycosaminoglycan, polysaccharides that are considered to have arisen in the last common unicellular ancestor of multicellular animals. In this light, the large interactome of HS and its myriad functions in relation to the regulation of cell communication are not surprising.
Alotaibi FS, Alsadun MMR, Alsaiari SA, Ramakrishnan K, Yates EA, Fernig DG.   +5 more
europepmc   +3 more sources

Heparan Sulfate Proteoglycans [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Stephane, Sarrazin, William C, Lamanna, Jeffrey D, Esko   +2 more
openaire   +2 more sources

Heparin Mimetics and Their Impact on Extracellular Matrix Protein Assemblies

Pharmaceuticals, 2023
Heparan sulfate is a crucial extracellular matrix component that organizes structural features and functional protein processes. This occurs through the formation of protein–heparan sulfate assemblies around cell surfaces, which allow for the deliberate ...
Fabian Heide, Manuel Koch, Jörg Stetefeld   +2 more
doaj   +1 more source

Roles of Heparan Sulfate Sulfation in Dentinogenesis [PDF]

Journal of Biological Chemistry, 2012
Cell surface heparan sulfate (HS) is an essential regulator of cell signaling and development. HS traps signaling molecules, like Wnt in the glycosaminoglycan side chains of HS proteoglycans (HSPGs), and regulates their functions. Endosulfatases Sulf1 and Sulf2 are secreted at the cell surface to selectively remove 6-O-sulfate groups from HSPGs ...
Hayano, S., Kurosaka, H., Yanagita, T., Kalus, Ina, Milz, Fabian, Ishihara, Y., Nururu, M. N., Kawanabe, N., Saito, M., Kamioka, H., Adachi, T., Dierks, Thomas, Yamashiro, T.   +12 more
openaire   +3 more sources

Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage

Biomedicines, 2020
Heparan sulfate is a highly sulfated polysaccharide abundant on the surface of hepatocytes and surrounding extracellular matrix. Emerging evidence demonstrates that heparan sulfate plays an important role in neutralizing the activities of proinflammatory
Katelyn Arnold, Yi-En Liao, Jian Liu
doaj   +1 more source