Results 1 to 10 of about 82,657 (310)
Probing Glycosaminoglycan–Protein Interactions: Applications of Surface Plasmon Resonance [PDF]
BiosensorsGlycosaminoglycans (GAGs) are highly negatively charged polysaccharides that play essential roles in numerous physiological and pathological processes through their interactions with proteins.
Changkai Bu +6 more
doaj +2 more sources
Frontiers in Chemistry, 2021 Glycosaminoglycans (GAGs) are important constituents of human glycome. They are negatively charged unbranched polysaccharides that are usually covalently attached to proteins, forming glycan-protein conjugates, called proteoglycans. Glycosaminoglycans play critical roles in numerous biological processes throughout individual development and are also ...
Yuefan, Song +2 more
+7 more sources
Molecules, 2022 Glycosaminoglycans (GAGs) are a class of periodic anionic linear polysaccharides involved in a number of biologically relevant processes in the extracellular matrix via interactions with various types of molecules including proteins, peptides and small ...
Martyna Maszota-Zieleniak +2 more
doaj +1 more source
Glycosaminoglycans in biomedicine [PDF]
WIREs Nanomedicine and Nanobiotechnology, 2013 AbstractGlycosaminoglycans (GAGs) compose one of four classes of mammalian biopolymers, and are arguably the most complex. The research areas of glycobiology, glycopolymers, and the use of GAGs within tissue engineering and regenerative medicine have grown exponentially during the past decade.
Rebecca A, Scott, Alyssa, Panitch
openaire +2 more sources
Glycosaminoglycans and infection [PDF]
Frontiers in Bioscience, 2016 Glycosaminoglycans (GAGs) are complex linear polysaccharides expressed in intracellular compartments, at the cell surface, and in the extracellular environment where they interact with various molecules to regulate many cellular processes implicated in health and disease. Subversion of GAGs is a pathogenic strategy shared by a wide variety of microbial
Rafael S, Aquino, Pyong Woo, Park
openaire +2 more sources
A method for characterising human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography-mass spectrometry with multiple reaction monitoring [PDF]
European Cells & Materials, 2018 Intervertebral disc (IVD) degeneration results in the depletion of proteoglycans and glycosaminoglycans (GAGs), which can lead to structural and mechanical loss of IVD function, ingrowth of nociceptive nerve fibres and eventually discogenic pain ...
X Liu +7 more
doaj +1 more source
Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease β Secretase, BACE1
Marine Drugs, 2021 Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years.
Courtney J. Mycroft-West +10 more
doaj +1 more source
Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide
Biomolecules, 2021 Pleiotrophin (PTN) is a potent cytokine that plays an important role in neural generation, angiogenesis, inflammation, and cancers. Its interactions with the polysaccharide glycosaminoglycan (GAG) are crucial to PTN’s biological activities. In this study,
Eathen O. Ryan +3 more
doaj +1 more source
Glycosaminoglycan Modification of Decorin Depends on MMP14 Activity and Regulates Collagen Assembly
Cells, 2020 Proper processing of collagens COL1 and COL6 is required for normal function of adipose tissue and skeletal muscle. Proteoglycan decorin (DCN) regulates collagen fiber formation.
Alexes C. Daquinag +4 more
doaj +1 more source
Glycosaminoglycans and Proteoglycans [PDF]
Pharmaceuticals, 2018 In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan, serglycin, cell-surface proteoglycans, like syndecans and glypicans, and the extracellular matrix ...
Vitor Pomin, Barbara Mulloy
openaire +3 more sources