Results 1 to 10 of about 70,721 (209)
Frontiers in Chemistry, 2021 Glycosaminoglycans (GAGs) are important constituents of human glycome. They are negatively charged unbranched polysaccharides that are usually covalently attached to proteins, forming glycan-protein conjugates, called proteoglycans. Glycosaminoglycans play critical roles in numerous biological processes throughout individual development and are also ...
Yuefan, Song +2 more
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Glycosaminoglycans in biomedicine [PDF]
WIREs Nanomedicine and Nanobiotechnology, 2013 AbstractGlycosaminoglycans (GAGs) compose one of four classes of mammalian biopolymers, and are arguably the most complex. The research areas of glycobiology, glycopolymers, and the use of GAGs within tissue engineering and regenerative medicine have grown exponentially during the past decade.
Rebecca A, Scott, Alyssa, Panitch
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Glycosaminoglycans and infection [PDF]
Frontiers in Bioscience, 2016 Glycosaminoglycans (GAGs) are complex linear polysaccharides expressed in intracellular compartments, at the cell surface, and in the extracellular environment where they interact with various molecules to regulate many cellular processes implicated in health and disease. Subversion of GAGs is a pathogenic strategy shared by a wide variety of microbial
Rafael S, Aquino, Pyong Woo, Park
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Glycosaminoglycans and Proteoglycans [PDF]
Pharmaceuticals, 2018 In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan, serglycin, cell-surface proteoglycans, like syndecans and glypicans, and the extracellular matrix ...
Vitor Pomin, Barbara Mulloy
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Glycosaminoglycans and the peritoneaum [PDF]
Nephrology, 2002 SUMMARY: The introduction of peritoneal dialysis (PD) over two decades ago has allowed us to manipulate the peritoneal membrane to perform as a continuous dialysing organ. to maximize the efficacy of solute transport and waste removal, conventional PD fluids require unphysiological concentrations of glucose to provide the osmotic drive, lactate to ...
Yung, S, Chan, TM
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Glycosaminoglycans and Their Mimetics [PDF]
Molecules, 2016 Glycosaminoglycans (GAGs) are linear, polyanionic polysaccharides that are ubiquitous on the mammalian cell surface and in the extracellular matrix and are generally found attached to a protein core as part of a proteoglycan.[...]
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Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]
International Journal of Molecular Sciences, 2019 Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans. They are present not only on the cell surface, but also in the intracellular milieu and extracellular matrix.
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
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Glycosaminoglycan–Protein Interactions: The First Draft of the Glycosaminoglycan Interactome [PDF]
Journal of Histochemistry & Cytochemistry, 2020 The six mammalian glycosaminoglycans (GAGs), chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, hyaluronan, and keratan sulfate, are linear polysaccharides. Except for hyaluronan, they are sulfated to various extent, and covalently attached to proteins to form proteoglycans.
Sylvain D, Vallet +2 more
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Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source