Results 31 to 40 of about 120,166 (348)

Glycosaminoglycans in the human cornea: age-related changes [PDF]

, 2015
AIM: To investigate possible age-related changes in glycosaminoglycans (GAGs) in the human cornea. The substances today called GAGs were previously referred to as mucopolysaccharides.
Anello, Giulia, Cavallotti, Carlo, De Paolis, Giulio, Pacella, Elena, Pacella, Fernanda, Parisella, Francesca Romana, Turchetti, Paolo   +6 more
core   +2 more sources

Mast cell glycosaminoglycans [PDF]

Glycoconjugate Journal, 2016
Mast cells contain granules packed with a mixture of proteins that are released on degranulation. The proteoglycan serglycin carries an array of glycosaminoglycan (GAG) side chains, sometimes heparin, sometimes chondroitin or dermatan sulphate. Tight packing of granule proteins is dependent on the presence of serglycin carrying these GAGs.
B. Mulloy, R. Lever, C. P. Page
openaire   +6 more sources

Meniscus-derived matrix scafolds promote the integrative repair of meniscal defects [PDF]

, 2019
Meniscal tears have a poor healing capacity, and damage to the meniscus is associated with significant pain, disability, and progressive degenerative changes in the knee joint that lead to osteoarthritis.
DeFrate, Louis E., Glass, Katherine A., Guilak, Farshid, McNulty, Amy L., Nishimuta, James F., Rowland, Christopher R., Ruprecht, Jacob C., Stencel, Jennifer, Waanders, Taylor D., Weinberg, J. Brice   +9 more
core   +2 more sources

Glycosaminoglycans and Proteoglycans [PDF]

Pharmaceuticals, 2018
In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan, serglycin, cell-surface proteoglycans, like syndecans and glypicans, and the extracellular matrix ...
Vitor Pomin, Barbara Mulloy
openaire   +3 more sources

A Toxoplasma gondii thioredoxin with cell adhesion and antioxidant function

Frontiers in Cellular and Infection Microbiology
BackgroundToxoplasma gondii (T. gondii) is a widespread, zoonotic protozoan intracellular parasite with a complex life cycle, which can cause toxoplasmosis, a potentially serious disease. During the invasion process, T.
Dawei Wang, Dawei Wang, Yuyi Shi, Yuyi Shi, Ziwen Cheng, Ziwen Cheng, Like Luo, Like Luo, Kuo Cheng, Kuo Cheng, Shengqi Gan, Shengqi Gan, Che Liu, Che Liu, Zeliang Chen, Baoling Yang, Baoling Yang   +16 more
doaj   +1 more source

Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Swim Bladder: Isolation, Structural Analysis, and Anticoagulant Activity

Marine Drugs, 2023
Glycosaminoglycans (GAGs) with unique structures from marine animals show intriguing pharmacological activities and negligible biological risks, providing more options for us to explore safer agents.
Yue Yao, Hao Tang, Haiqiong Ma, Zidong Liu, Jinwen Huang, Xiufen Yang, Longyan Zhao, Qingxia Yuan   +7 more
doaj   +1 more source

Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]

, 2008
Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric, Gutiérrez-Rivas, Monica, Pulido, Miguel R, Sobrino, Francisco, Sáiz, Margarita   +4 more
core   +3 more sources

Immunoenhancement Effects of Glycosaminoglycan from Apostichopus japonicus: In Vitro and In Cyclophosphamide-Induced Immunosuppressed Mice Studies

Marine Drugs, 2017
In this study, the immunomodulatory activities of Apostichopus japonicus glycosaminoglycan (AHG) on the nature killer (NK) cells, cytotoxic T lymphocytes (CTLs) and cyclophosphamide (CY)-treated mice were investigated.
Han Wang, Shuang Yang, Yuanhong Wang, Tingfu Jiang, Shuai Li, Zhihua Lv   +5 more
doaj   +1 more source

Dengue virus infection induces complement factor H but protein remains cell-associated, with changes intracellularly and in cell surface binding

Exploration of Immunology
Aim: Severe dengue is correlated with a decrease in the circulating complement regulator, factor H (FH) and prior work has shown that dengue virus (DENV) infection induces FH mRNA but not FH protein release.
Joshua G. Dubowsky, Binoy Appukuttan, Evangeline Cowell, Valeria Sanders, David L. Gordon, Jillian M. Carr   +5 more
doaj   +1 more source

Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice

Molecular Therapy: Methods & Clinical Development, 2017
Sanfilippo syndrome type B (mucopolysaccharidosis IIIB), caused by inherited deficiency of α-N-acetylglucosaminidase (NAGLU), required for lysosomal degradation of heparan sulfate (HS), is a pediatric neurodegenerative disorder with no approved treatment.
Mika Aoyagi-Scharber, Danielle Crippen-Harmon, Roger Lawrence, Jon Vincelette, Gouri Yogalingam, Heather Prill, Bryan K. Yip, Brian Baridon, Catherine Vitelli, Amanda Lee, Olivia Gorostiza, Evan G. Adintori, Wesley C. Minto, Jeremy L. Van Vleet, Bridget Yates, Sara Rigney, Terri M. Christianson, Pascale M.N. Tiger, Melanie J. Lo, John Holtzinger, Paul A. Fitzpatrick, Jonathan H. LeBowitz, Sherry Bullens, Brett E. Crawford, Stuart Bunting   +24 more
doaj   +1 more source