Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]
International Journal of Molecular Sciences, 2019 Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans. They are present not only on the cell surface, but also in the intracellular milieu and extracellular matrix.
openaire +3 more sources
Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review
Bioengineering, 2020 The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary ...
Colton J. Ross +4 more
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Anticoagulant effectiveness of glycosaminoglycan extracted from the scale of Binni, Mesopotamichthys sharpeyi (Cyprinidae) [PDF]
, 2021 Fishery wastes are one of natural resources to extract bioactive substances such as collagen and glycosaminoglycan (GAG). The anticoagulant activity of glycosaminoglycans extracted from Binni fish, Mesopotamichthys sharpeyi scales was the aim of this ...
Hassan, Neeran F. +2 more
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Comparison of siRNA-mediated silencing of glycosaminoglycan synthesis genes and enzyme replacement therapy for mucopolysaccharidosis in cell culture studies [PDF]
, 2012 Cytotoxicity of laronidase (Aldurazyme®), employed in enzyme replacement therapy (ERT) for mucopolysaccharidosis type I (MPS I) and various siRNAs, tested previously in studies on substrate reduction therapy (SRT) for mucopolysaccharidoses, was ...
Banecka-Majkutewicz, Zyta +5 more
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Chemical Modification of Hyaluronan and Their Biomedical Applications
Frontiers in Chemistry, 2022 Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts.
Vera Hintze +2 more
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The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard
Molecules, 2018 The enzyme heparanase, an endo-β-glucuronidase, degrades heparan sulfate (HS) chains on the cell surface and in the extracellular matrix. Heparanase regulates numerous biological processes that drive tumour growth, metastasis and angiogenesis.
Mohit Chhabra, Vito Ferro
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The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis
Frontiers in Cell and Developmental Biology, 2020 Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw. They represent not only the primary tumor site, but also potential metastatic lesions, and could thus be an attractive supplement for cancer diagnostics.
Theresa D. Ahrens +12 more
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Frontiers in Immunology, 2020 Proteoglycans (PGs), present in diverse environments, such as the cell membrane surface, extracellular milieu, and intracellular granules, are fundamental to life.
Krishna Rajarathnam +3 more
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Altered glycosaminoglycan of the pk mutant [PDF]
, 1977 Altered glycosaminoglycan of the pk ...
Springer, W. D. +3 more
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Interstitial Fluid in Lipedema and Control Skin
Women's Health Reports, 2020 Background: Fluid in lymphedema tissue appears histologically as spaces around vessels and between dermal skin fibers. Lipedema is a painful disease of excess loose connective tissue (fat) in limbs, almost exclusively of women, that worsens by stage ...
Marisol Allen +2 more
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