Results 31 to 40 of about 90,028 (262)

Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity [PDF]

, 2017
Aggressive cancers are characterized by hypoxia, which is a key driver of tumor development and treatment resistance. Proteins specifically expressed in the hypoxic tumor microenvironment thus represent interesting candidates for targeted drug delivery ...
Johannes Messinger, Pastorekova, Silvia, Pastorekova, Silvia,, Messinger, Johannes,, Ann-Sofie Månsson, Bourseau-Guilmain, Erika, Julien A. Menard, Shevela, Dmitry,, Christianson, Helena C, Silvia Pastorekova, Menard, Julien A, Lidfeldt, Jon,, Belting, Mattias,, Messinger, Johannes, Mattias Belting, Erika Bourseau-Guilmain, Shevela, Dmitry, Lidfeldt, Jon, Dmitry Shevela, Christianson, Helena C.,, Bourseau-Guilmain, Erika,, Christianson, Helena C,, Menard, Julien A.,, Chandran, Vineesh Indira,, Christianson, Helena C., Belting, Mattias, Chandran, Vineesh Indira, Mansson, Ann-Sofie, Helena C. Christianson, Vineesh Indira Chandran, Jon Lidfeldt, Mansson, Ann-Sofie,, Menard, Julien A,, Menard, Julien A., Lund University.   +34 more
core   +1 more source

Chondrodysplasias With Multiple Dislocations Caused by Defects in Glycosaminoglycan Synthesis

Frontiers in Genetics, 2021
Chondrodysplasias with multiple dislocations form a group of severe disorders characterized by joint laxity and multiple dislocations, severe short stature of pre- and post-natal onset, hand anomalies, and/or vertebral anomalies.
Johanne Dubail, Valérie Cormier-Daire, Valérie Cormier-Daire   +2 more
doaj   +1 more source

Glycosaminoglycan-Conjugated Insulin Derivatives Suitable for Once-Daily Formulations

, 2019
A novel, long-acting insulin conjugate was developed by modification with a glycosaminoglycan (GAG; i.e., chondroitin [CH] or heparosan [HPN]) at different positions (GlyA1, LysB29, or both) via different linkers with varying arm lengths.
Yoshihiro Takatsu (1773712), Kazuhiro Kojima (6482276), Tetsuya Ohtaki (1773685), Megumi Ichikawa (6482270), Tokiko Sakai (6482279), Tetsuya Hirayama (6482267), Masanobu Fukushima (6482264), Ikue Kitazawa (6482273)   +7 more
core   +1 more source

A New Glycosaminoglycan from the Giant African Snail Achatina fulica [PDF]

, 1996
Journal of Biological Chemistry, 271, 11750-11755Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY.
Kim, Y.S., Jo, Y.T., Chang, I.M., Toida, T.E., Linhardt, Robert J., Park, Y.   +5 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Fucoidan as a renal protectant: mechanistic insights and therapeutic implications of endothelial glycocalyx targeting

Frontiers in Pharmacology
The progression of chronic kidney disease (CKD) is closely associated with damage to the endothelial glycocalyx (eGC) of the renal microvasculature.
Ping Xin, Chengqiao Ge, Yufan Tang, Yifan He, Bin Fu   +4 more
doaj   +1 more source

Restoration of the Phenotype of Dedifferentiated Rabbit Chondrocytes by Sesquiterpene Farnesol

Pharmaceutics, 2022
Osteoarthritis (OA) is a joint disorder characterized by the progressive degeneration of articular cartilage. The phenotype and metabolism behavior of chondrocytes plays crucial roles in maintaining articular cartilage function.
Guan-Xuan Wu, Chun-Yu Chen, Chun-Shien Wu, Lain-Chyr Hwang, Shan-Wei Yang, Shyh-Ming Kuo   +5 more
doaj   +1 more source

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics

Pharmaceuticals, 2022
Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo. Some structures of PTN in solution have been solved, but no precise location of the binding site has been reported yet.
Jonathan R. Miles, Xu Wang, Jose L. de Paz, Pedro M. Nieto   +3 more
doaj   +1 more source

Fabrication of Aligned Polycaprolactone Nanofibrillar Bundles to Control Cell‐Mediated Collagen Deposition in Engineered Cartilage

Advanced Materials, EarlyView.
Melt electrofibrillation (MEF) enables the fabrication of nanofibrillar PCL scaffolds with defined architectures that guide cellular alignment and retention during cartilage tissue engineering. Unlike conventional melt electrowriting, MEF consistently directs collagen type II‐rich extracellular matrix organization, providing a tunable platform to ...
Alba Pueyo Moliner, Lennard Spauwen, James L. Martin Robinson, Ángela García Grech, Isabelle Martinier, Sara Grasselli, Aylin Kara Özenler, Matthias Ryma, Jürgen Groll, Mylène de Ruijter, Jos Malda   +10 more
wiley   +1 more source