Results 41 to 50 of about 88,458 (304)

A Toxoplasma gondii thioredoxin with cell adhesion and antioxidant function

Frontiers in Cellular and Infection Microbiology
BackgroundToxoplasma gondii (T. gondii) is a widespread, zoonotic protozoan intracellular parasite with a complex life cycle, which can cause toxoplasmosis, a potentially serious disease. During the invasion process, T.
Dawei Wang, Dawei Wang, Yuyi Shi, Yuyi Shi, Ziwen Cheng, Ziwen Cheng, Like Luo, Like Luo, Kuo Cheng, Kuo Cheng, Shengqi Gan, Shengqi Gan, Che Liu, Che Liu, Zeliang Chen, Baoling Yang, Baoling Yang   +16 more
doaj   +1 more source

Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Swim Bladder: Isolation, Structural Analysis, and Anticoagulant Activity

Marine Drugs, 2023
Glycosaminoglycans (GAGs) with unique structures from marine animals show intriguing pharmacological activities and negligible biological risks, providing more options for us to explore safer agents.
Yue Yao, Hao Tang, Haiqiong Ma, Zidong Liu, Jinwen Huang, Xiufen Yang, Longyan Zhao, Qingxia Yuan   +7 more
doaj   +1 more source

Glycosaminoglycan-Conjugated Insulin Derivatives Suitable for Once-Daily Formulations

, 2019
A novel, long-acting insulin conjugate was developed by modification with a glycosaminoglycan (GAG; i.e., chondroitin [CH] or heparosan [HPN]) at different positions (GlyA1, LysB29, or both) via different linkers with varying arm lengths.
Yoshihiro Takatsu (1773712), Kazuhiro Kojima (6482276), Tetsuya Ohtaki (1773685), Megumi Ichikawa (6482270), Tokiko Sakai (6482279), Tetsuya Hirayama (6482267), Masanobu Fukushima (6482264), Ikue Kitazawa (6482273)   +7 more
core   +1 more source

Enabling methodology for the end functionalisation of glycosaminoglycan oligosaccharides [PDF]

, 2008
-The chemical functionalisation of glycosaminoglycans is very challenging due to their structural heterogeneity and polyanionic character; but as an enabling technology it promises rich rewards in terms of the structural and biological data it will ...
Meyer, Odile, Hulme, Alison N., Uhrin, Dusan, Gemma, Emiliano   +3 more
core   +1 more source

Dengue virus infection induces complement factor H but protein remains cell-associated, with changes intracellularly and in cell surface binding

Exploration of Immunology
Aim: Severe dengue is correlated with a decrease in the circulating complement regulator, factor H (FH) and prior work has shown that dengue virus (DENV) infection induces FH mRNA but not FH protein release.
Joshua G. Dubowsky, Binoy Appukuttan, Evangeline Cowell, Valeria Sanders, David L. Gordon, Jillian M. Carr   +5 more
doaj   +1 more source

Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice

Molecular Therapy: Methods & Clinical Development, 2017
Sanfilippo syndrome type B (mucopolysaccharidosis IIIB), caused by inherited deficiency of α-N-acetylglucosaminidase (NAGLU), required for lysosomal degradation of heparan sulfate (HS), is a pediatric neurodegenerative disorder with no approved treatment.
Mika Aoyagi-Scharber, Danielle Crippen-Harmon, Roger Lawrence, Jon Vincelette, Gouri Yogalingam, Heather Prill, Bryan K. Yip, Brian Baridon, Catherine Vitelli, Amanda Lee, Olivia Gorostiza, Evan G. Adintori, Wesley C. Minto, Jeremy L. Van Vleet, Bridget Yates, Sara Rigney, Terri M. Christianson, Pascale M.N. Tiger, Melanie J. Lo, John Holtzinger, Paul A. Fitzpatrick, Jonathan H. LeBowitz, Sherry Bullens, Brett E. Crawford, Stuart Bunting   +24 more
doaj   +1 more source

Electrostatic Interactions Between Glycosaminoglycan Molecules

, 2005
The electrostatic interactions between nearest-neighbouring chondroitin sulfate glycosaminoglycan (CS-GAG) molecular chains are obtained on the bottle brush conformation of proteoglycan aggrecan based on an asymptotic solution of the Poisson-Boltzmann ...
Moyne C, 白以龙, Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, LNM, Beijing 100080, Peoples R China., 宋凡   +3 more
core   +2 more sources

Attenuation of arsenic-induced gut injury in mice by sulfated glycosaminoglycan from swim bladder via regulation of gut microbiota, metabolites, and intestinal barrier integrity

Food Science and Human Wellness
Arsenic, a known environmental carcinogen, disrupts intestinal homeostasis, posing a significant threat to human health. Mitigating its toxic effects is crucial, and this study explores the potential of swim bladder sulfated glycosaminoglycan (SBSG) in ...
Jieying Ou, Xiaofei Liu, Jing Chen, Houpei Huang, Xuejing Jia, Baojun Xu, Zhi-Ling Yu, Saiyi Zhong   +7 more
doaj   +1 more source

Chondrodysplasias With Multiple Dislocations Caused by Defects in Glycosaminoglycan Synthesis

Frontiers in Genetics, 2021
Chondrodysplasias with multiple dislocations form a group of severe disorders characterized by joint laxity and multiple dislocations, severe short stature of pre- and post-natal onset, hand anomalies, and/or vertebral anomalies.
Johanne Dubail, Valérie Cormier-Daire, Valérie Cormier-Daire   +2 more
doaj   +1 more source

Electron Detachment Dissociation of Glycosaminoglycan Tetrasaccharides [PDF]

, 2007
The first application of electron detachment dissociation (EDD) to carbohydrates is presented. The structural characterization of glycosaminoglycan (GAG) oligosaccharides by mass spectrometry is a longstanding problem because of the lability of these ...
Wolff, Jeremy J., Amster, I.J., Linhardt, Robert J., Chi, Lianli, Wolff, J.J., Amster, I. Jonathan, Chi, L.   +6 more
core   +1 more source