Results 61 to 70 of about 88,458 (304)
Advanced Healthcare Materials, EarlyView.Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira +8 more
wiley +1 more source
Chemogenesis of an Antiangiogenic Glycosaminoglycan
, 2015 In this letter we report a facile chemical conversion of heparin, a potent anticoagulant with minimal antiangiogenic activity, into an effective antiangiogenic glycosaminoglycan through optimized chemical approaches.
Sailaja Arungundram (1322373) +2 more
core +1 more source
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
Advanced Healthcare Materials, EarlyView.LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
, 2016 Hyperelongation of glycosaminoglycan chains on proteoglycans facilitates increased lipoprotein binding in the blood vessel wall and the development of atherosclerosis. Increased mRNA expression of glycosaminoglycan chain synthesizing enzymes in vivo is
Kamato, Danielle +8 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari +10 more
wiley +1 more source
3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress
Advanced Materials Technologies, EarlyView.Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi +4 more
wiley +1 more source
Encapsulation of a glycosaminoglycan in hydroxyapatite/alginate capsules
, 2009 The development of suitable vehicles for the delivery of growth-inducing factors to fracture sites is a challenging area of bone repair. Bone-specific glycosaminoglycan molecules are of particular interest because of their high stability and proven ...
Jejurikar, Aparna +5 more
core +1 more source
Patterned Screen‐Printing Process for Substrate‐Free and Scalable Hyaluronic Acid Microneedle Arrays
Advanced Materials Technologies, EarlyView.A substrate‐free microneedle array comprising a hybrid hyaluronic acid ink was fabricated via a scalable screen‐printing process for flexible transdermal drug delivery. Defect‐free mold filling was achieved using a vacuum‐assisted jig and a delayed drying system, and the use of this versatile platform for multi‐drug patterning and ex vivo skin ...
Sanghyun Ahn +3 more
wiley +1 more source
Effect of epithelial debridement on human cornea proteoglycans
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
doaj +1 more source
A New Glycosaminoglycan from the Giant African Snail Achatina fulica
, 1996 Journal of Biological Chemistry, 271, 11750-11755Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY.
Kim, Y.S. +5 more
core +1 more source