Results 81 to 90 of about 90,028 (262)

Function and contribution of two putative Enterococcus faecalis glycosaminoglycan degrading enzymes to bacteremia and catheter-associated urinary tract infection

Infection and Immunity
Enterococcus faecalis is a common cause of healthcare-acquired bloodstream infections and catheter-associated urinary tract infections (CAUTIs) in both adults and children. Treatment of E.
Alexandra O. Johnson, Brianna M. Shipman, Benjamin C. Hunt, Brian S. Learman, Aimee L. Brauer, Serena P. Zhou, Rachael Hageman Blair, Nicole J. De Nisco, Chelsie E. Armbruster   +8 more
doaj   +1 more source

Home treatment of type VI mucopolysaccharidosis (Maroteaux‐Lamy syndrome) an alternative at this time of COVID‐19 pandemic: A case in Peru

Clinical Case Reports, 2020
We report a patient with mucopolysaccharidosis type VI, on long‐term enzyme replacement home therapy. Results support the efficacy and safety benefits, with additional advantage of home therapy to minimize the risk of community‐transmitted infections.
Jenny Lucy Cortez Miranda, Lincoln Blacido Trujillo, María Elena Liendo Chocano   +2 more
doaj   +1 more source

Host and Pathogen Glycosaminoglycan-Binding Proteins Modulate Antimicrobial Peptide Responses in Drosophila melanogaster!†

, 2010
During group B streptococcal infection, the alpha C protein (ACP) on the bacterial surface binds to host cell surface heparan sulfate proteoglycans (HSPGs) and facilitates entry of bacteria into human epithelial cells.
Miriam J. Baron, Robert J. Linhardt, Wang, Zhipeng, Flax, Lindsay A., Linhardt, Robert J., Kemp, Melissa M., Zhipeng Wang, Lindsay A. Flax, Melissa M. Kemp, Baron, Miriam J.   +9 more
core   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Effects of Intramuscular Injections of Glycosaminoglycan Polysulfates on Signs of Incipient Hip Dysplasia in Growing Dogs [PDF]

, 1992
38 pages, 1 article*Effects of Intramuscular Injections of Glycosaminoglycan Polysulfates on Signs of Incipient Hip Dysplasia in Growing Dogs* (Lust, George; Williams, Alma J.; Burton-Wurster, Nancy; Beck, Kathy A.; Rubin, Gail) 38 ...
Williams, Alma J., Rubin, Gail, Beck, Kathy A., Lust, George, Burton-Wurster, Nancy, Cornell University. Dept. of Biological Statistics and Computational Biology., Cornell University. Biometrics Unit., Cornell University. Dept. of Biometrics.   +7 more
core   +3 more sources

Cant1 Affects Cartilage Proteoglycan Properties: Aggrecan and Decorin Characterization in a Mouse Model of Desbuquois Dysplasia Type 1

Biomolecules
Desbuquois dysplasia type 1 (DBQD1) is a recessive chondrodysplasia caused by mutations in the CANT1 gene, encoding for the Golgi Calcium-Activated Nucleotidase 1 (CANT1). The enzyme hydrolyzes UDP, the by-product of glycosyltransferase reactions, but it
Chiara Gramegna Tota, Alessandra Leone, Asifa Khan, Antonella Forlino, Antonio Rossi, Chiara Paganini   +5 more
doaj   +1 more source

Rectal absorption of some glycosaminoglycan sulphates and heparin in rats

, 1981
A standardized extract of glycosaminoglycan sulphates containing heparin, with a low affinity for antithrombin III, and a commercial heparin were administered to rats, by the rectal route.
G MASCELLANI, P BIANCHINI, L STANZANI, G P CORBELLI   +3 more
core   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Pathogens that infect mammalian cells via sulfonated glycosaminoglycans

Frontiers in Cellular and Infection Microbiology
Sulfonated glycosaminoglycans, such as heparan sulfate and dermatan sulfate, form major components of the cell surface and extracellular matrix, and display vital roles in mammalian physiology, including growth and development.
Jessica S. Morris, Paul A. Dawson
doaj   +1 more source

The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle

, 2016
Hyperelongation of glycosaminoglycan chains on proteoglycans facilitates increased lipoprotein binding in the blood vessel wall and the development of atherosclerosis. Increased mRNA expression of glycosaminoglycan chain synthesizing enzymes in vivo is
Kamato, Danielle, Osman, Narin, Rostam, Muhamad Ashraf, Zheng, Wenhua, Little, Peter J, Rostam, Muhamad A, Piva, Terence J., Little, Peter J., Piva, Terence J   +8 more
core   +1 more source