Results 71 to 80 of about 88,458 (304)

A Cryopreservation‐Based Supply Chain Strategy for Extrusion Bioprinting in Space

Advanced Materials Technologies, EarlyView.
Extrusion bioprinting on crewed space platforms requires a bioink that stays functional along the logistic chain. Here, cells and biomaterial ink travel separately, the cells cryopreserved and the ink cold stored, and are combined only minutes before printing.
Johannes Windisch, Max von Witzleben, Richard Frank Richter, Finn Dani, Constantin Greil, Sarah Duin, Anja Lode, Michael Gelinsky   +7 more
wiley   +1 more source

Heparin Mimics Extracellular DNA in Binding to Cell Surface-Localized Proteins and Promoting Staphylococcus aureus Biofilm Formation

mSphere, 2017
Staphylococcus aureus is a leading cause of catheter-related bloodstream infections. Biofilms form on these implants and are held together by a matrix composed of proteins, polysaccharides, and extracellular DNA (eDNA).
Surabhi Mishra, Alexander R. Horswill
doaj   +1 more source

Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells [PDF]

, 2016
A major feature of early age-related macular degeneration (AMD) is the thickening of Bruch's membrane in the retina and an alteration in its composition with increased lipid deposition. In certain pathological conditions proteoglycans are responsible for
Kamato, Danielle, Thach, Lyna, Osman, Narin, Getachew, Robel, Zheng, Wenhua, Liang, X. -L., Little, Peter J, Liang, X-L, Al Gwairi, Othman, Little, Peter J.   +9 more
core   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis

, 2013
Background: The zebrafish is an important developmental model. Surprisingly, there are few studies that describe the glycosaminoglycan composition of its extracellular matrix during skeletogenesis.
Mitchell, Ruth E, Mitchell, Ruth E., Hayes, Anthony J, Hammond, Chrissy L., Reynolds, Scott, Hayes, Anthony Joseph, Caterson, Bruce, Bashford, Andrew, Hammond, Chrissy L   +8 more
core   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Proton Conductivity of Glycosaminoglycans

PLOS ONE, 2018
Abstract Proton (H + ) conductivity is important in many natural phenomena including oxidative phosphorylation in mitochondria and archea, uncoupling membrane potentials by the antibiotic Gramicidin, and proton actuated bioluminescence in dinoflagellate.
Selberg, John, Jia, Manping, Rolandi, Marco   +2 more
openaire   +4 more sources

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Rectal absorption of some glycosaminoglycan sulphates and heparin in rats

, 1981
A standardized extract of glycosaminoglycan sulphates containing heparin, with a low affinity for antithrombin III, and a commercial heparin were administered to rats, by the rectal route.
G MASCELLANI, P BIANCHINI, L STANZANI, G P CORBELLI   +3 more
core   +1 more source

Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity [PDF]

, 2017
Aggressive cancers are characterized by hypoxia, which is a key driver of tumor development and treatment resistance. Proteins specifically expressed in the hypoxic tumor microenvironment thus represent interesting candidates for targeted drug delivery ...
Johannes Messinger, Pastorekova, Silvia, Pastorekova, Silvia,, Messinger, Johannes,, Ann-Sofie Månsson, Bourseau-Guilmain, Erika, Julien A. Menard, Shevela, Dmitry,, Christianson, Helena C, Silvia Pastorekova, Menard, Julien A, Lidfeldt, Jon,, Belting, Mattias,, Messinger, Johannes, Mattias Belting, Erika Bourseau-Guilmain, Shevela, Dmitry, Lidfeldt, Jon, Dmitry Shevela, Christianson, Helena C.,, Bourseau-Guilmain, Erika,, Christianson, Helena C,, Menard, Julien A.,, Chandran, Vineesh Indira,, Christianson, Helena C., Belting, Mattias, Chandran, Vineesh Indira, Mansson, Ann-Sofie, Helena C. Christianson, Vineesh Indira Chandran, Jon Lidfeldt, Mansson, Ann-Sofie,, Menard, Julien A,, Menard, Julien A., Lund University.   +34 more
core   +1 more source