Results 91 to 100 of about 88,458 (304)

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Raman Investigation of Cardiac Tissues with Sodium-Induced High Stiffness

Molecules
This study investigates the molecular and mechanical effects of sodium accumulation in myocardial tissue using a combination of physiological measurements and Raman spectroscopy.
Igor Artyukov, Gregory Arutyunov, Dmitrii Dragunov, Nikolay Melnik, Elena Perevedentseva, Vadim M. Mitrokhin, Anna Sokolova   +6 more
doaj   +1 more source

Home treatment of type VI mucopolysaccharidosis (Maroteaux‐Lamy syndrome) an alternative at this time of COVID‐19 pandemic: A case in Peru

Clinical Case Reports, 2020
We report a patient with mucopolysaccharidosis type VI, on long‐term enzyme replacement home therapy. Results support the efficacy and safety benefits, with additional advantage of home therapy to minimize the risk of community‐transmitted infections.
Jenny Lucy Cortez Miranda, Lincoln Blacido Trujillo, María Elena Liendo Chocano   +2 more
doaj   +1 more source

Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation

, 2020
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.

core   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Function and contribution of two putative Enterococcus faecalis glycosaminoglycan degrading enzymes to bacteremia and catheter-associated urinary tract infection

Infection and Immunity
Enterococcus faecalis is a common cause of healthcare-acquired bloodstream infections and catheter-associated urinary tract infections (CAUTIs) in both adults and children. Treatment of E.
Alexandra O. Johnson, Brianna M. Shipman, Benjamin C. Hunt, Brian S. Learman, Aimee L. Brauer, Serena P. Zhou, Rachael Hageman Blair, Nicole J. De Nisco, Chelsie E. Armbruster   +8 more
doaj   +1 more source

Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer's disease

, 2010
The b-site APP cleaving enzyme (BACE1) is responsible for the first step in the production of the b-amyloid protein of Alzheimer’s disease. BACE1 is synthesized as a partially active zymogen (proBACE1). We previously showed that the glycosaminoglycan
Klaver, DW (15531932), Lisa Foa (14736694), Freeman, C (15526505), David Small (14749594), Aguilar, MI (15518651), Robert Gasperini (14737258), Parish, C (15531941), Juliano, JP (15531938), Wilce, MCJ (15531935)   +8 more
core  

Thin Layer Chromatography for the Analysis of Glycosaminoglycan Oligosaccharides

, 2007
Analytical Biochemistry, 371, 118–120Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY.
Linhardt, Robert J., Zhang, Fuming, Xie, Jin, Zhang, Zhenqing   +3 more
core   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Cant1 Affects Cartilage Proteoglycan Properties: Aggrecan and Decorin Characterization in a Mouse Model of Desbuquois Dysplasia Type 1

Biomolecules
Desbuquois dysplasia type 1 (DBQD1) is a recessive chondrodysplasia caused by mutations in the CANT1 gene, encoding for the Golgi Calcium-Activated Nucleotidase 1 (CANT1). The enzyme hydrolyzes UDP, the by-product of glycosyltransferase reactions, but it
Chiara Gramegna Tota, Alessandra Leone, Asifa Khan, Antonella Forlino, Antonio Rossi, Chiara Paganini   +5 more
doaj   +1 more source