Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides [PDF]
, 2020 Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date.
Grabarics, Márkó +9 more
core +1 more source
One-electron oxidation and reduction of glycosaminoglycan chloramides: a kinetic study. [PDF]
, 2013 Hypochlorous acid and its acid-base counterpart, hypochlorite ions, produced under inflammatory conditions, may produce chloramides of glycosaminoglycans, these being significant components of the extracellular matrix (ECM).
A.W.J. Paterson +67 more
core +1 more source
Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review
Bioengineering, 2020 The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary ...
Colton J. Ross +4 more
doaj +1 more source
Structural Evidence for the Tetrameric Assembly of Chemokine CCL11 and the Glycosaminoglycan Arixtra™. [PDF]
, 2013 Understanding chemokine interactions with glycosaminoglycans (GAG) is critical as these interactions have been linked to a number of inflammatory medical conditions, such as arthritis and asthma.
Dykstra, Andrew B +2 more
core +2 more sources
The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard
Molecules, 2018 The enzyme heparanase, an endo-β-glucuronidase, degrades heparan sulfate (HS) chains on the cell surface and in the extracellular matrix. Heparanase regulates numerous biological processes that drive tumour growth, metastasis and angiogenesis.
Mohit Chhabra, Vito Ferro
doaj +1 more source
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis
Frontiers in Cell and Developmental Biology, 2020 Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw. They represent not only the primary tumor site, but also potential metastatic lesions, and could thus be an attractive supplement for cancer diagnostics.
Theresa D. Ahrens +12 more
doaj +1 more source
Impact of bidirectional relationships between streptococcus anginosus group and host tissue matrix components on cellular activity: Role in establishment of infection [PDF]
, 2003 This paper investigates pathogenic mechanisms of the Streptococcus anginosus group (SAG) of bacteria which influence the biological activity of periodontal ligament (PDL) cells, endothelial cells and also how matrix proteins produced by these host cells ...
Waddington, Rachel J. +4 more
core +10 more sources
Frontiers in Immunology, 2020 Proteoglycans (PGs), present in diverse environments, such as the cell membrane surface, extracellular milieu, and intracellular granules, are fundamental to life.
Krishna Rajarathnam +3 more
doaj +1 more source
Glycosaminoglycan Functionalized Nanoparticles Exploit Glycosaminoglycan Functions
, 2014 Nanoparticles are being explored for a variety of applications including medical imaging, drug delivery, and biochemical detection. Surface functionalization of nanoparticles with glycosaminoglycans (GAGs) is an attractive strategy that is only starting to be investigated to improve their properties for biological and therapeutic applications.
Vassie, JA, Whitelock, JM, Lord, MS
openaire +3 more sources
Relationship Between Quantitative MRI Biomarkers and Patient-Reported Outcome Measures After Cartilage Repair Surgery: A Systematic Review. [PDF]
, 2018 Background:Treatment of articular cartilage injuries remains a clinical challenge, and the optimal tools to monitor and predict clinical outcomes are unclear.
Cole, Brian J +4 more
core +1 more source