Data on cloning, expression and biochemical characteristics of a chondroitin sulfate/dermatan sulfate 4-O-endosulfatase [PDF]
Data in Brief, 2023 The data shown in this article are related to the published paper entitled “A novel 4-O-endosulfatase with high potential for the structure-function studies of chondroitin sulfate/dermatan sulfate” in Carbohydrate Polymers.
Lin Wei +9 more
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Research and Application of Chondroitin Sulfate/Dermatan Sulfate-Degrading Enzymes [PDF]
Frontiers in Cell and Developmental Biology, 2020 Chondroitin sulfate (CS) and dermatan sulfate (DS) are widely distributed on the cell surface and in the extracellular matrix in the form of proteoglycan, where they participate in various biological processes.
Wenshuang Wang +3 more
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Dermatan Sulfate: Structure, Biosynthesis, and Biological Roles [PDF]
BiomoleculesDermatan sulfate (DS) is a remarkably versatile glycosaminoglycan that plays critical roles across a wide array of biological processes. Its unique structure, characterized by repeating disaccharide units of N-acetyl-D-galactosamine (GalNAc) and Iduronic
Congcong Chen +7 more
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Delineation of musculocontractural Ehlers–Danlos Syndrome caused by dermatan sulfate epimerase deficiency [PDF]
Molecular Genetics & Genomic Medicine, 2020 Background Musculocontractural Ehlers–Danlos Syndrome (mcEDS) is a rare connective tissue disorder caused by biallelic loss‐of‐function variants in CHST14 (mcEDS‐CHST14) or DSE (mcEDS‐DSE), both of which result in defective dermatan sulfate biosynthesis.
Charlotte K. Lautrup +12 more
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Comparative Study of Two Chondroitin Sulfate/Dermatan Sulfate 4-O-Sulfatases With High Identity [PDF]
Frontiers in Microbiology, 2019 Chondroitin sulfate/dermatan sulfate (CS/DS) sulfatases are potential tools for structural and functional studies of CD/DS chains. In our previous study, a CS/DS 4-O-endosulfatase (endoVB4SF) was identified from a marine bacterium (Wang et al., 2015 ...
Shumin Wang +6 more
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Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders [PDF]
Pharmaceuticals, 2017 The indispensable roles of dermatan sulfate-proteoglycans (DS-PGs) have been demonstrated in various biological events including construction of the extracellular matrix and cell signaling through interactions with collagen and transforming growth factor-
Shuji Mizumoto +3 more
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Shipin gongye ke-ji, 2022 Taking permeate liquid in the process of extracting heparin from porcine intestinal mucosa as raw material, the extraction process of dermatan sulfate was optimized to explore the antioxidant capacity of dermatan sulfate.
Yubao WANG +9 more
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Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles
Frontiers in Cell and Developmental Biology, 2021 Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, heparan sulfate, and keratan sulfate, except for hyaluronan that is a free polysaccharide, are covalently attached to core proteins to form proteoglycans.
Yi-Fan Huang +2 more
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Hallmarks of glycogene expression and glycosylation pathways in squamous and adenocarcinoma cervical cancer [PDF]
PeerJ, 2021 Background Dysregulation of glycogene expression in cancer can lead to aberrant glycan expression, which can promote tumorigenesis. Cervical cancer (CC) displays an increased expression of glycogenes involved in sialylation and sialylated glycans.
Patricia Martinez-Morales +8 more
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Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis. [PDF]
PLoS ONE, 2015 The epimerization of glucuronic acid into iduronic acid adds structural variability to chondroitin/dermatan sulfate polysaccharides. Iduronic acid-containing domains play essential roles in processes such as coagulation, chemokine and morphogen ...
Xanthi N Stachtea +6 more
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