Shipin gongye ke-ji, 2022 Taking permeate liquid in the process of extracting heparin from porcine intestinal mucosa as raw material, the extraction process of dermatan sulfate was optimized to explore the antioxidant capacity of dermatan sulfate.
Yubao WANG +9 more
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Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles
Frontiers in Cell and Developmental Biology, 2021 Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, heparan sulfate, and keratan sulfate, except for hyaluronan that is a free polysaccharide, are covalently attached to core proteins to form proteoglycans.
Yi-Fan Huang +2 more
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Hallmarks of glycogene expression and glycosylation pathways in squamous and adenocarcinoma cervical cancer [PDF]
PeerJ, 2021 Background Dysregulation of glycogene expression in cancer can lead to aberrant glycan expression, which can promote tumorigenesis. Cervical cancer (CC) displays an increased expression of glycogenes involved in sialylation and sialylated glycans.
Patricia Martinez-Morales +8 more
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Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis. [PDF]
PLoS ONE, 2015 The epimerization of glucuronic acid into iduronic acid adds structural variability to chondroitin/dermatan sulfate polysaccharides. Iduronic acid-containing domains play essential roles in processes such as coagulation, chemokine and morphogen ...
Xanthi N Stachtea +6 more
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Studies on the biosynthesis of dermatan sulfate [PDF]
FEBS Letters, 1971 It is generally accepted that the biosynthesis of polysaccharide proteins in mammalian tissues follows a certain schedule [ 1,2] involving four principal steps: (a) formation of the polypeptide backbone, (b) stepwise addition of monosaccharide units from the appropiate nucleotide sugars to form the linkage j e ion to protein, and (c) the alternate ...
Malmström, A., Fransson, L.-Å.
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Two Dermatan Sulfate Epimerases Form Iduronic Acid Domains in Dermatan Sulfate [PDF]
Journal of Biological Chemistry, 2009 A second dermatan sulfate epimerase (DS-epi2) was identified as a homolog of the first epimerase (DS-epi1), which was previously described by our group. DS-epi2 is 1,222 amino acids long and has an approximately 700-amino acid N-terminal epimerase domain that is highly conserved between the two enzymes.
Benny, Pacheco +2 more
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DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling. [PDF]
PLoS ONE, 2018 Remodeling of the extracellular matrix (ECM) in the tumor microenvironment promotes glioma progression. Chondroitin sulfate (CS) proteoglycans appear in the ECM and on the cell surface, and can be catalyzed by dermatan sulfate epimerase to form ...
Wen-Chieh Liao +7 more
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Biosynthesis of Dermatan Sulfate [PDF]
Journal of Biological Chemistry, 2006 We identified the gene encoding chondroitin-glucuronate C5-epimerase (EC 5.1.3.19) that converts d-glucuronic acid to l-iduronic acid residues in dermatan sulfate biosynthesis. The enzyme was solubilized from bovine spleen, and an ∼43,000-fold purified preparation containing a major 89-kDa candidate component was subjected to mass spectrometry analysis
Maccarana, Marco +7 more
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Effect of epithelial debridement on human cornea proteoglycans
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
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Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. [PDF]
PLoS Genetics, 2018 Gerodermia osteodysplastica (GO) is characterized by skin laxity and early-onset osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of poorly characterized function.
Wing Lee Chan +22 more
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