Results 21 to 30 of about 232,697 (206)
A Possible Role for Arylsulfatase G in Dermatan Sulfate Metabolism. [PDF]
Int J Mol Sci, 2020 Perturbations of glycosaminoglycan metabolism lead to mucopolysaccharidoses (MPS)—lysosomal storage diseases. One type of MPS (type VI) is associated with a deficiency of arylsulfatase B (ARSB), for which we previously established a cellular model ...
Poterala-Hejmo A +5 more
europepmc +2 more sources
Sequencing the Dermatan Sulfate Chain of Decorin. [PDF]
J Am Chem Soc, 2017 Glycomics represents one of the last frontiers and most challenging in omic analysis. Glycosylation occurs in the endoplasmic reticulum and the Golgi organelle and its control is neither well-understood nor predictable based on proteomic or genomic analysis.
Yu Y +8 more
europepmc +4 more sources
Disaccharide composition of chondroitin sulfate/dermatan sulfate (CS/DS) in the spine and limb.
, 2023 Disaccharide composition of chondroitin sulfate/dermatan sulfate (CS/DS) in the spine and limb.
Tsukasa Yonekura (15285878) +8 more
core +1 more source
Biosynthesis of Dermatan Sulfate [PDF]
Journal of Biological Chemistry, 2006 We identified the gene encoding chondroitin-glucuronate C5-epimerase (EC 5.1.3.19) that converts d-glucuronic acid to l-iduronic acid residues in dermatan sulfate biosynthesis. The enzyme was solubilized from bovine spleen, and an ∼43,000-fold purified preparation containing a major 89-kDa candidate component was subjected to mass spectrometry analysis
Maccarana, Marco +7 more
openaire +1 more source
DSE promotes aggressive glioma cell phenotypes by enhancing HB-EGF/ErbB signaling. [PDF]
PLoS ONE, 2018 Remodeling of the extracellular matrix (ECM) in the tumor microenvironment promotes glioma progression. Chondroitin sulfate (CS) proteoglycans appear in the ECM and on the cell surface, and can be catalyzed by dermatan sulfate epimerase to form ...
Wen-Chieh Liao +7 more
doaj +1 more source
Effect of epithelial debridement on human cornea proteoglycans
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
doaj +1 more source
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. [PDF]
PLoS Genetics, 2018 Gerodermia osteodysplastica (GO) is characterized by skin laxity and early-onset osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of poorly characterized function.
Wing Lee Chan +22 more
doaj +1 more source
Antithrombin activity and disaccharide composition of dermatan sulfate from different bovine tissues [PDF]
, 2007 Dermatan sulfate is a glycosaminoglycan that selectively inhibits the action of thrombin through interaction with heparin cofactor II. Unlike heparin it does not interact with other coagulation factors and is able to inhibit thrombin associated with ...
Daniel, Robyn A. +7 more
core +1 more source
PLoS Pathogens, 2020 Lyme disease, caused by Borrelia burgdorferi, B. afzelii and B. garinii, is a chronic, multi-systemic infection and the spectrum of tissues affected can vary with the Lyme disease strain. For example, whereas B.
Yi-Pin Lin +6 more
doaj +1 more source
Molecules, 2017 Glycosaminoglycans are complex biomolecules of great biological and medical importance. The quantification of glycosaminoglycans, in particular in complex matrices, is challenging due to their inherent structural heterogeneity.
Melissa Rappold +2 more
doaj +1 more source