Research and Application of Chondroitin Sulfate/Dermatan Sulfate-Degrading Enzymes [PDF]
Frontiers in Cell and Developmental Biology, 2020 Chondroitin sulfate (CS) and dermatan sulfate (DS) are widely distributed on the cell surface and in the extracellular matrix in the form of proteoglycan, where they participate in various biological processes.
Fuchuan Li, Wenshuang Wang
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Data on cloning, expression and biochemical characteristics of a chondroitin sulfate/dermatan sulfate 4-O-endosulfatase [PDF]
Data in Brief, 2023 The data shown in this article are related to the published paper entitled “A novel 4-O-endosulfatase with high potential for the structure-function studies of chondroitin sulfate/dermatan sulfate” in Carbohydrate Polymers.
Lin Wei +9 more
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Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders [PDF]
Pharmaceuticals, 2017 The indispensable roles of dermatan sulfate-proteoglycans (DS-PGs) have been demonstrated in various biological events including construction of the extracellular matrix and cell signaling through interactions with collagen and transforming growth factor-
Shuhei Yamada +2 more
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Dermatan Sulfate: Structure, Biosynthesis, and Biological Roles [PDF]
BiomoleculesDermatan sulfate (DS) is a remarkably versatile glycosaminoglycan that plays critical roles across a wide array of biological processes. Its unique structure, characterized by repeating disaccharide units of N-acetyl-D-galactosamine (GalNAc) and Iduronic
Congcong Chen +7 more
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The Interaction between Chondroitin Sulfate and Dermatan Sulfate Tetrasaccharides and Pleiotrophin. [PDF]
Int J Mol Sci, 2022 Pleiotrophin (PTN) is a neurotrophic factor that participates in the development of the embryonic central nervous system (CNS) and neural stem cell regulation by means of an interaction with sulfated glycosaminoglycans (GAGs). Chondroitin sulfate (CS) is the natural ligand in the CNS.
García-Jiménez MJ +3 more
europepmc +4 more sources
Sequencing the Dermatan Sulfate Chain of Decorin. [PDF]
J Am Chem Soc, 2017 Glycomics represents one of the last frontiers and most challenging in omic analysis. Glycosylation occurs in the endoplasmic reticulum and the Golgi organelle and its control is neither well-understood nor predictable based on proteomic or genomic analysis.
Yu Y +8 more
europepmc +4 more sources
Delineation of musculocontractural Ehlers–Danlos Syndrome caused by dermatan sulfate epimerase deficiency [PDF]
Molecular Genetics & Genomic Medicine, 2020 Background Musculocontractural Ehlers–Danlos Syndrome (mcEDS) is a rare connective tissue disorder caused by biallelic loss‐of‐function variants in CHST14 (mcEDS‐CHST14) or DSE (mcEDS‐DSE), both of which result in defective dermatan sulfate biosynthesis.
Charlotte K. Lautrup +12 more
doaj +2 more sources
The Specific Role of Dermatan Sulfate as an Instructive Glycosaminoglycan in Tissue Development [PDF]
International Journal of Molecular Sciences, 2022 Shuhei Yamada, Shuji Mizumoto
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Bioactive Glycosaminoglycans from Caranx crysos: A Structure–Function Study of Selective Anticoagulant Activity [PDF]
Marine DrugsGlycosaminoglycans (GAGs) are the carbohydrate portion of proteoglycans (PGS), a family of complex biomacromolecules ubiquitously found in the extracellular matrix and on cell surfaces that play critical roles in a plethora of physiological and ...
Ranim Kroumi +9 more
doaj +2 more sources
Comparative Study of Two Chondroitin Sulfate/Dermatan Sulfate 4-O-Sulfatases With High Identity [PDF]
Frontiers in Microbiology, 2019 Chondroitin sulfate/dermatan sulfate (CS/DS) sulfatases are potential tools for structural and functional studies of CD/DS chains. In our previous study, a CS/DS 4-O-endosulfatase (endoVB4SF) was identified from a marine bacterium (Wang et al., 2015 ...
Shumin Wang +6 more
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