Two Dermatan Sulfate Epimerases Form Iduronic Acid Domains in Dermatan Sulfate [PDF]
Journal of Biological Chemistry, 2009 A second dermatan sulfate epimerase (DS-epi2) was identified as a homolog of the first epimerase (DS-epi1), which was previously described by our group. DS-epi2 is 1,222 amino acids long and has an approximately 700-amino acid N-terminal epimerase domain that is highly conserved between the two enzymes.
Benny, Pacheco +2 more
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Inhibition of Dermatan Sulfate Epimerase 1 by Substituted Glucuronic Acids. [PDF]
ACS OmegaDermatan sulfate epimerase 1 (DS-epi1) is a key enzyme in the biosynthesis of the glycosaminoglycan chondroitin sulfate/dermatan sulfate, catalyzing the conversion of glucuronic acid to iduronic acid at the polymer level.
Mastio R +8 more
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Degradation of Chondroitin Sulfate and Dermatan Sulfate with Chondroitin Lyases
, 2003 in Methods in Molecular Biology, Proteoglycan Protocols: Current Methods and Applications, Vol. 171, R.V. Iozzo, ed., Humana Press, Totowa, NJ, Chap. 36, pp 363-371Note : if this item contains full text it may be a preprint, author manuscript, or a Gold ...
M J, Hernáiz, R J, Linhardt
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, 1992 A process of chemical depolymerization of dermatan sulfate (DS) byfree radicals ispresented. The low molecular weight dermatan sulfate (LMW-DS) obtained by radicai fragmentation is characterized by physico-chemicalproperties (molecular weight, sulfate/carboxyl ratto, uronic acid percentage, electrophoretic profile), purity (by thè agarose ...
VOLPI, Nicola +3 more
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Hallmarks of glycogene expression and glycosylation pathways in squamous and adenocarcinoma cervical cancer [PDF]
PeerJ, 2021 Background Dysregulation of glycogene expression in cancer can lead to aberrant glycan expression, which can promote tumorigenesis. Cervical cancer (CC) displays an increased expression of glycogenes involved in sialylation and sialylated glycans.
Patricia Martinez-Morales +8 more
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The Interaction between Chondroitin Sulfate and Dermatan Sulfate Tetrasaccharides and Pleiotrophin. [PDF]
Int J Mol Sci, 2022 Pleiotrophin (PTN) is a neurotrophic factor that participates in the development of the embryonic central nervous system (CNS) and neural stem cell regulation by means of an interaction with sulfated glycosaminoglycans (GAGs). Chondroitin sulfate (CS) is the natural ligand in the CNS.
García-Jiménez MJ +3 more
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Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis. [PDF]
PLoS ONE, 2015 The epimerization of glucuronic acid into iduronic acid adds structural variability to chondroitin/dermatan sulfate polysaccharides. Iduronic acid-containing domains play essential roles in processes such as coagulation, chemokine and morphogen ...
Xanthi N Stachtea +6 more
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Histories of Dermatan Sulfate Epimerase and Dermatan 4-O-Sulfotransferase from Discovery of Their Enzymes and Genes to Musculocontractural Ehlers-Danlos Syndrome. [PDF]
Genes (Basel), 2023 Dermatan sulfate (DS) and its proteoglycans are essential for the assembly of the extracellular matrix and cell signaling. Various transporters and biosynthetic enzymes for nucleotide sugars, glycosyltransferases, epimerase, and sulfotransferases, are ...
Mizumoto S, Yamada S.
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Dermatan Sulfate Epimerase 1-Deficient Mice have Reduced Content and Changed Distribution of Iduronic acids in Dermatan Sulfate and an Altered Collagen Structure in Skin. [PDF]
, 2009 Dermatan sulfate epimerase 1 (DS-epi1) and 2 convert glucuronic acid to iduronic acid in chondroitin/dermatan sulfate biosynthesis. Here we report on the generation of DS-epi1-null mice and the resulting alterations in the chondroitin/dermatan ...
Oldberg, Åke +10 more
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Studies on the biosynthesis of dermatan sulfate [PDF]
FEBS Letters, 1971 It is generally accepted that the biosynthesis of polysaccharide proteins in mammalian tissues follows a certain schedule [ 1,2] involving four principal steps: (a) formation of the polypeptide backbone, (b) stepwise addition of monosaccharide units from the appropiate nucleotide sugars to form the linkage j e ion to protein, and (c) the alternate ...
Malmström, A., Fransson, L.-Å.
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