Results 31 to 40 of about 11,964 (213)

Preparation and purification of Flavobacterium heparinum chondroitinases AC and B by hydrophobic interaction chromatography

Brazilian Journal of Medical and Biological Research, 1999
Flavobacterium heparinum is a soil bacterium that produces several mucopolysaccharidases such as heparinase, heparitinases I and II, and chondroitinases AC, B, C and ABC. The purpose of the present study was to optimize the preparation of F.
J.A.K. Aguiar, Y.M. Michelacci
doaj   +1 more source

Left-sided valvular heart disease and retinopathy in a 38-year-old woman with attenuated mucopolysaccharidosis: a case report

Therapeutic Advances in Rare Disease, 2023
Mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders caused by deficient levels and/or activity of glycosaminoglycan (GAG)-degradative enzymes.
Faizal Z. Asumda, Jessica A. Kraker, Sarah C. Thomas, Joseph Maleszewski, Edwin M. Stone, Brendan C. Lanpher, Lisa A. Schimmenti   +6 more
doaj   +1 more source

Modular automated solid phase synthesis of dermatan sulfate oligosaccharides [PDF]

, 2014
Dermatan sulfates are glycosaminoglycan polysaccharides that serve a multitude of biological roles as part of the extracellular matrix. Orthogonally protected D-galactosamine and L-iduronic acid building blocks and a photo- cleavable linker are ...
Kandasamy, J., Klein, J., Klein, James C., Hahm, H., Schuhmacher, Frank, Hahm, Heung Sik, Schuhmacher, F., Seeberger, Peter H., Kandasamy, Jeyakumar, Seeberger, P.   +9 more
core   +1 more source

Production and characterization of monoclonal antibody to dermatan sulfate proteoglycan.

, 1988
We purified dermatan sulfate proteoglycan (PG) from the capsule of human ovarian fibroma for use as an immunogen. A monoclonal antibody, designated 6B6, was produced which reacts to the intact molecule of dermatan sulfate PG and the chondroitinase AC ...
T Ogura, M Sobue, N Nakashima, T Fukatsu, T Nagasaka, J Takeuchi, T Katoh   +6 more
core   +1 more source

The Dermatan Sulfate-Protein Linkage Region

Journal of Biological Chemistry, 1968
A study was made to identify the components of the region of linkage between polysaccharide and protein of dermatan sulfate from umbilical cord. The sulfated mucopolysaccharides were obtained after digestion of the tissue with pepsin and trypsin, and a dermatan sulfate-polypeptide preparation was isolated and purified.
A, Bella, I, Danishefsky
openaire   +2 more sources

Sulfated glycosaminoglycans in human vocal fold lamina propria

Brazilian Journal of Otorhinolaryngology
Introduction: The distribution, concentration and function of glycosaminoglycans in the various vocal fold tissues are still unclear. Objective: To evaluate the distribution and concentration of sulfated glycosaminoglycans in different layers of the ...
Sung Woo Park, Gustavo Polacow Korn, Elsa Yoko Kobayashi, João Roberto Maciel Martins, Noemi Grigoletto De Biase   +4 more
doaj   +1 more source

Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration.

PLoS ONE, 2011
As C-Xyloside has been suggested to be an initiator of glycosaminoglycan (GAG) synthesis, and GAGs such as Dermatan sulfate (DS) are potent enhancers of fibroblast growth factor (FGF)--10 action, we investigated if a C-Xylopyranoside derivative, (C-β-D ...
Jun Muto, Nandita Natasha Naidu, Kenshi Yamasaki, Nathalie Pineau, Lionel Breton, Richard L Gallo   +5 more
doaj   +1 more source

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Electron detachment dissociation of dermatan sulfate oligosaccharides [PDF]

Journal of the American Society for Mass Spectrometry, 2008
The structural characterization of glycosaminoglycans (GAG) oligosaccharides has been a long-standing challenge in the field of mass spectrometry. In this work, we present the application of electron detachment dissociation (EDD) Fourier transform mass spectrometry to the analysis of dermatan sulfate (DS) oligosaccharides up to 10 residues long.
Wolff, Jeremy J., Laremore, Tatiana N., Busch, Alexander M., Linhardt, Robert J., Amster, I. Jonathan   +4 more
openaire   +2 more sources

Distribution of Chondroitin Sulfate and Dermatan Sulfate in Normal and Inflamed Human Gingivae

, 1992
The effect of inflammation on the distribution of chondroitin sulfate and dermatan sulfate proteoglycans was assessed after normal and inflamed human gingivae were stained with monoclonal antibodies against these extracellular matrix macromolecules. The
P.M. Bartold
core   +1 more source