Results 31 to 40 of about 11,998 (213)

Galactosaminoglycans from normal myometrium and leiomyoma

Brazilian Journal of Medical and Biological Research, 2001
In many tumors, the amount of chondroitin sulfate in the extracellular matrix has been shown to be elevated when compared to the corresponding normal tissue. Nevertheless, the degree of chondroitin sulfate increase varies widely.
A.G.A. Berto, S.M. Oba, Y.M. Michelacci, L.O. Sampaio   +3 more
doaj   +1 more source

Pharmacodynamics and pharmacokinetics of dermatan sulfate in humans [PDF]

Blood, 1989
Dermatan sulfate (DS), a catalyst of the thrombin-heparin cofactor II interaction, has antithrombotic activity and is devoid of significant hemorrhagic risk in several animal models. We investigated the pharmacodynamic and pharmacokinetic properties of DS in humans. DS was injected in single bolus intravenous injections of four increasing doses (0.5, 1,
F, Dol, G, Houin, M, Rostin, J L, Montastruc, D, Dupouy, F, Gianese, P, Sie, B, Boneu   +7 more
openaire   +3 more sources

Preparation and purification of Flavobacterium heparinum chondroitinases AC and B by hydrophobic interaction chromatography

Brazilian Journal of Medical and Biological Research, 1999
Flavobacterium heparinum is a soil bacterium that produces several mucopolysaccharidases such as heparinase, heparitinases I and II, and chondroitinases AC, B, C and ABC. The purpose of the present study was to optimize the preparation of F.
J.A.K. Aguiar, Y.M. Michelacci
doaj   +1 more source

Hunter syndrome revisited [PDF]

Romanian Medical Journal, 2020
Hunter syndrome is the type II of mucopolysaccharidose. With impaired glycosaminoglycan catabolism, heparan and dermatan sulfate accumulate in lysosomes. Multiple organ dysfunction is a consequence of this effect.
Dan Cristian Gheorghe, Adina Zamfir-Chiru-Anton, AE Stanciu   +2 more
doaj   +1 more source

Modular automated solid phase synthesis of dermatan sulfate oligosaccharides [PDF]

, 2014
Dermatan sulfates are glycosaminoglycan polysaccharides that serve a multitude of biological roles as part of the extracellular matrix. Orthogonally protected D-galactosamine and L-iduronic acid building blocks and a photo- cleavable linker are ...
Kandasamy, J., Klein, J., Klein, James C., Hahm, H., Schuhmacher, Frank, Hahm, Heung Sik, Schuhmacher, F., Seeberger, Peter H., Kandasamy, Jeyakumar, Seeberger, P.   +9 more
core   +1 more source

Left-sided valvular heart disease and retinopathy in a 38-year-old woman with attenuated mucopolysaccharidosis: a case report

Therapeutic Advances in Rare Disease, 2023
Mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders caused by deficient levels and/or activity of glycosaminoglycan (GAG)-degradative enzymes.
Faizal Z. Asumda, Jessica A. Kraker, Sarah C. Thomas, Joseph Maleszewski, Edwin M. Stone, Brendan C. Lanpher, Lisa A. Schimmenti   +6 more
doaj   +1 more source

dermatan sulfate from beef mucosa - structure, physicochemical and biological properties of fractions prepared by chemical depolymerization and anion-exchange chromatography [PDF]

, 1994
Dermatan sulfate was extracted and purified from beef intestinal mucosa. The structure and physicochemical properties were evaluated by different techniques, such as, disaccharide pattern, relative molecular mass, sulfate-to-carboxyl ratio, and ...
VOLPI, Nicola, Nicola Volpi
core   +1 more source

Sulfated glycosaminoglycans in human vocal fold lamina propria

Brazilian Journal of Otorhinolaryngology
Introduction: The distribution, concentration and function of glycosaminoglycans in the various vocal fold tissues are still unclear. Objective: To evaluate the distribution and concentration of sulfated glycosaminoglycans in different layers of the ...
Sung Woo Park, Gustavo Polacow Korn, Elsa Yoko Kobayashi, João Roberto Maciel Martins, Noemi Grigoletto De Biase   +4 more
doaj   +1 more source

Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration.

PLoS ONE, 2011
As C-Xyloside has been suggested to be an initiator of glycosaminoglycan (GAG) synthesis, and GAGs such as Dermatan sulfate (DS) are potent enhancers of fibroblast growth factor (FGF)--10 action, we investigated if a C-Xylopyranoside derivative, (C-β-D ...
Jun Muto, Nandita Natasha Naidu, Kenshi Yamasaki, Nathalie Pineau, Lionel Breton, Richard L Gallo   +5 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source