Reaction of superoxide radicals with glycosaminoglycan chloramides: a kinetic study. [PDF]
, 2013 Hypochlorous acid and its acid-base counterpart, hypochlorite ions, produced under inflammatory conditions, may produce chloramides of glycosaminoglycans, perhaps through the binding of myeloperoxidase directly to the glycosaminoglycans.
A.W.J. Paterson +57 more
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Investigating the Role of Aggrecan in Intervertebral Disc Degeneration [PDF]
, 2018 Low back pain affects nearly 85% of the population of the United States, and is associated with a huge socioeconomic burden. One of the leading causes of low back pain is Intervertebral Disc (IVD) degeneration, which results in an ingrowth of blood ...
King, Brian
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Intra-articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate [PDF]
, 2010 Objective: Insulin-like growth factor 1 (IGF-1) stimulates cartilage repair but is not a practical therapy due to its short half-life. We have previously modified IGF-1 by adding a heparin-binding domain and have shown that this fusion protein (HB-IGF-1)
Cole, Ada A. +6 more
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Transport studies of chondroitin sulfate disaccharide through articular cartilage [PDF]
, 1997 Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.Includes bibliographical references (leaves 56-57).by Julianne Jiang Zhu.M ...
Zhu, Julianne Jiang
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Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory [PDF]
, 2017 Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory.
Fawcett, JW +3 more
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Catabolism of chondroitin sulfate
Cellular and Molecular Biology Letters, 2015 AbstractChondroitin sulfate (CS) is a ubiquitous component of the cell surface and extracellular matrix of animal tissues. CS chains are covalently bound to a core protein to form a proteoglycan, which is involved in various biological events including cell proliferation, migration, and invasion.
openaire +2 more sources
Systemic Glycosaminoglycan Clearance by HARE/Stabilin-2 Activates Intracellular Signaling
Cells, 2020 Scavenger receptors perform essential functions, critical to maintaining mammalian physiologic homeostasis by continuously clearing vast numbers of biomolecules from blood, interstitial fluid and lymph. Stabilin-2 (Stab2) and the Hyaluronic Acid Receptor
Paul H. Weigel
doaj +1 more source
Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling [PDF]
, 2006 The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a
Dietrich, Carl Peter +2 more
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Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin
Journal of Inflammation, 2006 Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology.
Patsch Josef R +6 more
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Revisión del tratamiento farmacológico de las condropatías [PDF]
, 2007 Se procede a una revisión de la terapéutica actual de las condropatías en la medicina del deporte, y en especial de los fármacos de acción sintomática lenta para el tratamiento de dichas patologías como son el condroitín sulfato, el sulfato de ...
Abad Santos, Francisco +1 more
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