Results 21 to 30 of about 30,002 (237)
Neuroactive Chondroitin Sulfate Glycomimetics [PDF]
Journal of the American Chemical Society, 2008 We report the generation of chondroitin sulfate (CS) glycomimetics with tunable chemical and biological properties. Our approach greatly simplifies the synthesis of complex glycosaminoglycans, providing synthetically accessible, bioactive structures of programmable sulfation sequence.
Rawat, Manish +3 more
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Journal of Alzheimer's Disease Reports, 2023 Background: Chondroitin sulfate and chondroitin sulfate proteoglycans have been associated with Alzheimer’s disease (AD), and the impact of modified chondroitin sulfates is being investigated in several animal and cell-based models of AD.
Sumit Bhattacharyya, Joanne K. Tobacman
doaj +1 more source
Cell Reports, 2016 The basement membrane is crucial for cell polarity, adhesion, and motility, but how it is assembled on the cell surface remains unclear. Here, we find that ablation of glycosaminoglycan (GAG) side chains of proteoglycans in the neuroretina disrupts the ...
Chenqi Tao, Xin Zhang
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Glycosaminoglycans – types, structure, functions, and the role in wound healing processes
Annales Academiae Medicae Silesiensis, 2023 Glycosaminoglycans (GAGs) are a group of heteropolysaccharides, which include: chondroitin sulfates, dermatan sulfates, heparan sulfates, heparin, keratan sulfates, and hyaluronic acid.
Kinga Orlińska +4 more
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Chondroitin Sulfates Affect the Formation of the Segmental Motor Nerves in Zebrafish Embryos [PDF]
, 2000 Chondroitin sulfates have been implicated in the promotion and in the inhibition of axon growth. In the zebrafish embryo, chondroitin sulfates are present at the interface of the somites and the notochord where spinal motor axons extend ventrally to ...
Schachner, Melitta, Bernhardt, Robert R.
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Chondroitin sulfates modulate axon guidance in embryonic Xenopus brain [PDF]
, 1998 Chondroitin sulfate proteoglycans display both inhibitory and stimulatory effects on cell adhesion and neurite outgrowth in vitro. The functional activity of these proteoglycans appears to be context specific and dependent on the presence of different ...
Walz, A. +7 more
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Bolʹ, Sustavy, Pozvonočnik, 2022 Background. Bone health is relevant for patients of all age groups. Special attention is paid to childhood and adolescence, since it is during this period that bone mass is actively accumulated, which depends on the structural and functional state of the
T.V. Frolova +6 more
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The effect of increasing the sulfation level of chondroitin sulfate on anticoagulant specific activity and activation of the kinin system. [PDF]
PLoS ONE, 2018 Oversulfated chondroitin sulfate (OSCS) was identified as a contaminant in certain heparin preparations as the cause of adverse reactions in patients. OSCS was found to possess both plasma anticoagulant activity and the ability to activate prekallikrein ...
J Hogwood +6 more
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Preparation of Low Molecular Weight Chondroitin Sulfates, Screening of a High Anti-Complement Capacity of Low Molecular Weight Chondroitin Sulfate and Its Biological Activity Studies in Attenuating Osteoarthritis. [PDF]
Int J Mol Sci, 2016 Chondroitin sulfate (CS) plays important roles in the complement system. However, the CS structure is complicated due to different sources and the number and positions of sulfate groups.
Li L +7 more
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Antigenicity of Chondroitin Sulfate.
Experimental Biology and Medicine, 1957 SummaryChondroitin sulfate extracted from human costal cartilage was prepared in 3 different ways for inoculation into rabbits, (1) a 1% solution, (2) a 1% solution incubated with heat-killed, group A, type 3, hemolytic streptococcus, and (3) a 1% solution incubated with heat-killed Staphylococcus aureus. These 3 preparations were injected into rabbits
R W, QUINN, R, CERRONI
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