Background: Chondroitin sulfate and chondroitin sulfate proteoglycans have been associated with Alzheimer’s disease (AD), and the impact of modified chondroitin sulfates is being investigated in several animal and cell-based models of AD.
Sumit Bhattacharyya, Joanne K. Tobacman
doaj +1 more source
The basement membrane is crucial for cell polarity, adhesion, and motility, but how it is assembled on the cell surface remains unclear. Here, we find that ablation of glycosaminoglycan (GAG) side chains of proteoglycans in the neuroretina disrupts the ...
Chenqi Tao, Xin Zhang
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Preparation of Low Molecular Weight Chondroitin Sulfates, Screening of a High Anti-Complement Capacity of Low Molecular Weight Chondroitin Sulfate and Its Biological Activity Studies in Attenuating Osteoarthritis. [PDF]
Chondroitin sulfate (CS) plays important roles in the complement system. However, the CS structure is complicated due to different sources and the number and positions of sulfate groups.
Li L +7 more
europepmc +2 more sources
Glycosaminoglycans – types, structure, functions, and the role in wound healing processes
Glycosaminoglycans (GAGs) are a group of heteropolysaccharides, which include: chondroitin sulfates, dermatan sulfates, heparan sulfates, heparin, keratan sulfates, and hyaluronic acid.
Kinga Orlińska +4 more
doaj +1 more source
Background. Bone health is relevant for patients of all age groups. Special attention is paid to childhood and adolescence, since it is during this period that bone mass is actively accumulated, which depends on the structural and functional state of the
T.V. Frolova +6 more
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The effect of increasing the sulfation level of chondroitin sulfate on anticoagulant specific activity and activation of the kinin system. [PDF]
Oversulfated chondroitin sulfate (OSCS) was identified as a contaminant in certain heparin preparations as the cause of adverse reactions in patients. OSCS was found to possess both plasma anticoagulant activity and the ability to activate prekallikrein ...
J Hogwood +6 more
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Antigenicity of Chondroitin Sulfate.
SummaryChondroitin sulfate extracted from human costal cartilage was prepared in 3 different ways for inoculation into rabbits, (1) a 1% solution, (2) a 1% solution incubated with heat-killed, group A, type 3, hemolytic streptococcus, and (3) a 1% solution incubated with heat-killed Staphylococcus aureus. These 3 preparations were injected into rabbits
R W, QUINN, R, CERRONI
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Evaluation of an Amniotic Membrane-Collagen Dermal Substitute in the Management of Full-Thickness Skin Defects in a Pig [PDF]
Background To minimize the inflammatory reaction and improve healing, a new modified dermal substitute composed of an atelocollagen, chondroitin-6-sulfate, and amniotic membrane (AM) was applied to full-thickness skin defects in a pig. Atelocollagen was
Hyunji Kim +6 more
doaj +2 more sources
Horizontal gene transfer contributed to the evolution of extracellular surface structures [PDF]
The single-cell layered ectoderm of the fresh water polyp Hydra fulfills the function of an epidermis by protecting the animals from the surrounding medium.
Böttger, Angelika +13 more
core +1 more source
Molecular effects of chondroguard in osteoarthritis and herniated discs
Chondroitin sulfates (CS) are a building material for the cartilage and have anti-inflammatory and antioxidant effects. The paper gives the results of analyzing the pharmaceutical composition of chondroguard and its pharmaceutical substance CS-BIOACTIVE (
A. M. Lila +4 more
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