Results 1 to 10 of about 11,431 (185)
Identification of Multiple Sulfatase Deficiency (MSD) in newborn screening: A case study [PDF]
Molecular Genetics and Metabolism ReportsA patient with multiple sulfatase deficiency (MSD) was identified through a lysosomal storage disorder enzyme analysis panel, based on a characteristic pattern of reduced activities across multiple sulfatases.
Taraka R. Donti +2 more
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Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis [PDF]
Nature CommunicationsConvergence and extension (C&E) cell movements that elongate the primary embryonic axis are precisely timed during vertebrate gastrulation, but mechanisms controlling their onset remain unknown.
Ailen Soledad Cervino +7 more
doaj +2 more sources
Bacterial constipation: Mucin-degrading intestinal commensal bacteria cause constipation [PDF]
Gut MicrobesThe contribution of gut microbes to constipation remains mechanistically underexplored, despite constipation being one of the most prevalent gastrointestinal disorders.
Tomonari Hamaguchi +17 more
doaj +2 more sources
Biodistribution of Idursulfase Formulated for Intrathecal Use (Idursulfase-IT) in Cynomolgus Monkeys after Intrathecal Lumbar Administration. [PDF]
PLoS ONE, 2016 Enzyme replacement therapy with intravenous idursulfase (recombinant iduronate-2-sulfatase) is approved for the treatment of Hunter syndrome. Intravenous administration does not, however, treat the neurological manifestations, due to its low central ...
Jou-Ku Chung +4 more
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Биопрепараты: Профилактика, диагностика, лечение, 2022 Mucopolysaccharidosis type VI (Maroteaux–Lamy syndrome) is an orphan genetic disease caused by deficiency of the lysosomal enzyme arylsulfatase B (ASB).
S. S. Timonova +8 more
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Novel 3-Substituted 8-Methoxycoumarin Derivatives as Anti-Breast Cancer Drugs
Crystals, 2023 Scientists have been interested in hybrid coumarin derivatives due to their wide clinical anticancer use. Herein, ethyl 8-methoxycoumarin-3-carboxylate (Compound 1) served as the starting material for the synthesis of a series of novel hybrid coumarin ...
Tarfah Al-Warhi +8 more
doaj +1 more source
Pharmaceuticals, 2023 The molecular imaging of biomarkers plays an increasing role in medical diagnostics. In particular, the imaging of enzyme activity is a promising approach, as it enables the use of its inherent catalytic activity for the amplification of an imaging ...
Ilse M. Welleman +5 more
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Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
Profiling Urinary Sulfate Metabolites With Mass Spectrometry
Frontiers in Molecular Biosciences, 2022 The study of urinary phase II sulfate metabolites is central to understanding the role and fate of endogenous and exogenous compounds in biological systems.
Christopher C. J. Fitzgerald +8 more
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HS and Inflammation: A Potential Playground for the Sulfs?
Frontiers in Immunology, 2020 Heparan sulfate (HS) is a complex polysaccharide abundantly found in extracellular matrices and cell surfaces. HS participates in major cellular processes, through its ability to bind and modulate a wide array of signaling proteins.
Rana El Masri +3 more
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