The Aromatase–Estrogen System in the Testes of Non-Mammalian Vertebrates
Animals, 2021 Estrogens are important physiological regulators of testicular activity in vertebrates. Estrogen levels depend on the activity of P450 aromatase, the enzyme responsible for the irreversible conversion of testosterone into 17β-estradiol.
Luigi Rosati +4 more
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Preparation of a novel antiserum to aromatase with high affinity and specificity: Its clinicopathological significance on breast cancer tissue. [PDF]
PLoS ONE, 2017 Aromatase inhibitors have been widely used for the endocrine treatment of estrogen-dependent breast cancer in postmenopausal patients. However, clinicopathological studies of aromatase have been limited due to unsatisfactory specificity and/or restricted
Naoki Kanomata +6 more
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Epitope characterization of an aromatase monoclonal antibody suitable for the assessment of intratumoral aromatase activity. [PDF]
PLoS ONE, 2009 Immunohistochemistry is one of the most suitable methods for the detection of intratumoral aromatase in order to identify patients who may respond to aromatase inhibitor therapy in hormone-dependent breast cancer.
Yanyan Hong +7 more
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Quantitative analysis of long-form aromatase mRNA in the male and female rat brain. [PDF]
PLoS ONE, 2014 In vitro studies show that estrogens acutely modulate synaptic function in both sexes. These acute effects may be mediated in vivo by estrogens synthesized within the brain, which could fluctuate more rapidly than circulating estrogens.
Nino Tabatadze +2 more
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Frontiers in Oncology, 2022 Treatment of patients with castration-resistant prostate cancer (CRPC) remains a major clinical challenge. We previously showed that estrogenic effects contribute to CRPC progression and are primarily caused by the increased endogenous estradiol produced
Qimei Lin +11 more
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Biology, 2023 The enzyme aromatase is expressed at high levels in the ventromedial hypothalamic nucleus (VMN), a principal component of the brain gluco-regulatory network.
Karen P. Briski +4 more
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Estrogens: a new player in spermatogenesis.
Folia Histochemica et Cytobiologica, 2008 The mammalian testis serves two main functions: production of spermatozoa and synthesis of steroids; among them, estrogens are the end products obtained from the irreversible transformation of androgens by aromatase.
Camille Bois +5 more
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Computational method for aromatase-related proteins using machine learning approach.
PLoS ONE, 2023 Human aromatase enzyme is a microsomal cytochrome P450 and catalyzes aromatization of androgens into estrogens during steroidogenesis. For breast cancer therapy, third-generation aromatase inhibitors (AIs) have proven to be effective; however patients ...
Muthu Krishnan Selvaraj, Jasmeet Kaur
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Potential utility of natural products as regulators of breast cancer-associated aromatase promoters
Reproductive Biology and Endocrinology, 2011 Aromatase, the key enzyme in estrogen biosynthesis, converts androstenedione to estrone and testosterone to estradiol. The enzyme is expressed in various tissues such as ovary, placenta, bone, brain, skin, and adipose tissue.
Walker Larry A +4 more
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PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs
Scientific Reports, 2021 Aromatase is an estrogen synthetic enzyme that plays important roles in brain functions. To quantify aromatase expression in the brain by positron emission tomography (PET), we had previously developed [11C]cetrozole, which showed high specificity and ...
Kayo Takahashi +9 more
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