Results 41 to 50 of about 94,383 (270)

Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice

Neural Plasticity, 2016
Numerous studies show that 17β-estradiol (E2) protects against Alzheimer’s disease (AD) induced neurodegeneration. The E2-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is
Janine Prange-Kiel, Danuta A. Dudzinski, Felicitas Pröls, Markus Glatzel, Jakob Matschke, Gabriele M. Rune   +5 more
doaj   +1 more source

Adherence to adjuvant therapy in post-menopausal breast cancer patients: A review [PDF]

, 2011
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 John Wiley & Sons, IncThis review aimed to address the concept of adherence to adjuvant therapy in post-menopausal women.
Banning, M
core   +1 more source

Design of Novel Letrozole Analogues Targeting Aromatase for Breast Cancer: Molecular Docking, Molecular Dynamics, and Theoretical Studies on Gold Nanoparticles

Metabolites, 2023
The use of aromatase inhibitors is an established therapy for estrogen-dependent breast cancer in postmenopausal women. However, the only commercially available aromatase inhibitor, letrozole, is not highly selective; in addition to aromatase, it has an ...
Alaa Edris, Mohammed Abdelrahman, Wadah Osman, Asmaa E. Sherif, Ahmed Ashour, Elrashied A. E. Garelnabi, Sabrin R. M. Ibrahim, Rawan Bafail, Waad A. Samman, Kholoud F. Ghazawi, Gamal A. Mohamed, Abdulrahim A. Alzain   +11 more
doaj   +1 more source

Medial Amygdalar Aromatase Neurons Regulate Aggression in Both Sexes

Cell Reports, 2015
Aromatase-expressing neuroendocrine neurons in the vertebrate male brain synthesize estradiol from circulating testosterone. This locally produced estradiol controls neural circuits underlying courtship vocalization, mating, aggression, and territory ...
Elizabeth K. Unger, Kenneth J. Burke Jr., Cindy F. Yang, Kevin J. Bender, Patrick M. Fuller, Nirao M. Shah   +5 more
doaj   +1 more source

Hormonal Homologies between Canine Mammary Cancer and Human Breast Cancer in a Series of Cases

Veterinary Sciences, 2022
The validity of spontaneous canine mammary cancer (CMC) as a natural model for the study of human breast cancer (HBC) from a hormonal point of view has never been thoroughly investigated.
Paloma Jimena de Andrés, Sara Cáceres, Juan Carlos Illera, Belén Crespo, Gema Silván, Felisbina Luisa Queiroga, Maria José Illera, Maria Dolores Pérez-Alenza, Laura Peña   +8 more
doaj   +1 more source

Identification of subgroups of early breast cancer patients at high risk of nonadherence to adjuvant hormone therapy: results of an italian survey. [PDF]

, 2015
The aim of this study was the identification of subgroups of patients at higher risk of nonadherence to adjuvant hormone therapy for breast cancer. Using recursive partitioning and amalgamation (RECPAM) analysis, the highest risk was observed in the ...
Cianchetti E, Fabbri MA, Fanizza C, Fattoruso SI, Gambale E, Gamucci T, Gori S, Grassadonia A, Laudadio L, Longo F, Mauri M, Mazzilli L, Moscetti L, Natoli C., Nuzzo A, Romero M, SEMINARA, Patrizia, Tinari N, Vaccaro A, Vici P   +19 more
core   +1 more source

Locally Advanced Breast Cancer Patient’s Recurrence Rates Comparison Received Steroidal and Nonsteroidal Aromatase Inhibitor Based on Luminal

Biomolecular and Health Science Journal
Introduction: Aromatase inhibitors are hormonal therapies used in menopausal breast cancer with positive progesterone receptors and/or estrogen receptors.
Desak Gede Agung Suprabawati, Bernadeta Hernik Setiyandari, Dwi Hari Susilo, Bara Kharisma, Rizki Amalia   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Testosterone affects song modulation during simulated territorial intrusions in male black redstarts (Phoenicurus ochruros) [PDF]

, 2012
Although it has been suggested that testosterone plays an important role in resource allocation for competitive behavior, details of the interplay between testosterone, territorial aggression and signal plasticity are largely unknown.
Apfelbeck, Beate, Bartell, Paul A., Goymann, Wolfgang, Kiefer, Sarah, Kipper, Silke, Mortega, Kim G.   +5 more
core   +3 more sources

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source