Results 41 to 50 of about 58,906 (283)
Molecules, 2020 In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of androgens to estrogens. Aromatase inhibition is an important way to control estrogen-related diseases and estrogen levels.
Ulviye Acar Çevik +7 more
doaj +1 more source
A Multiple-Array SPRi Biosensor as a Tool for Detection of Gynecological–Oncological Diseases
Biosensors, 2023 Diagnostics based on the determination of biomarkers in body fluids will be more successful when several biomarkers are determined. A multiple-array SPRi biosensor for the simultaneous determination of CA125, HE4, CEA, IL-6 and aromatase has been ...
Beata Szymanska +3 more
doaj +1 more source
Androgens: Clinical Research and Therapeutics, 2021 The aromatase cytochrome P450 (P450arom) enzyme, or estrogen synthase, which is coded by the CYP19A1 gene, is widely expressed in a subpopulation of excitatory and inhibitory neurons, astrocytes, and other cell types in the human brain.
Iñigo Azcoitia +2 more
openaire +3 more sources
Study of Aromatase-Catalyzed Metabolic Switching of 2,2-Dimethylandrostenedione : Synthesis of Possible Metabolites and Their Inhibitory Activities of Aromatase [PDF]
, 2004 Aromatase is a cytochrome P-450 enzyme responsible for the conversion of androgens to estrogens. 2,2-Dimethylandrostenedione (5) is one of the powerful inhibitors of the enzyme.
山田, 恵子 +11 more
core
Preventative therapies for healthy women at high risk of breast cancer [PDF]
, 2014 Ivana Sestak Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UKAbstract: Tamoxifen has been shown to reduce the risk of developing estrogen receptor (ER)-positive ...
Sestak I, Sestak, I
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Indian Journal of Endocrinology and Metabolism, 2012 Despite being an obscure pharaoh who ruled for a very short time, Tutankhamun, the boy king, has reigned popular consciousness since the discovery of his tomb in 1922. To endocrinologists, the depiction of the kings of the 18 th dynasty in an androgynous
Krishna G Seshadri
doaj +1 more source
A novel compound heterozigous mutation of the aromatase gene in an adult man [PDF]
, 2006 Descriptions of a new case of human aromatase deficiency useful for a better understanding of male oestrogen ...
LUBERTO, Alessandra +12 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The Journal of Poultry Science, 2002 We examined whether very low-density lipoprotein receptors (VLDLR) on the oocyte membrane contributed to changes in VLDL uptake into the yolk by the ovarian follicle during the ovulation cycle of the laying hen.
Taisuke Baba +4 more
doaj +1 more source