Results 21 to 30 of about 94,383 (270)

PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs

Scientific Reports, 2021
Aromatase is an estrogen synthetic enzyme that plays important roles in brain functions. To quantify aromatase expression in the brain by positron emission tomography (PET), we had previously developed [11C]cetrozole, which showed high specificity and ...
Kayo Takahashi, Takamitsu Hosoya, Kayo Onoe, Tomoko Mori, Shusaku Tazawa, Aya Mawatari, Yasuhiro Wada, Yumiko Watanabe, Hisashi Doi, Yasuyoshi Watanabe   +9 more
doaj   +1 more source

Role of the aryl hydrocarbon receptor in Sugen 5416-induced experimental pulmonary hypertension [PDF]

, 2018
Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH).
Dean, Afshan, Docherty, Craig K., Gregorc, Teja, Harvey, Katie Y., MacLean, Margaret R., Morrell, Nicholas W., Nilsen, Margaret   +6 more
core   +1 more source

Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses

Frontiers in Molecular Neuroscience, 2018
Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase is expressed in the testes, ovaries, brain, and other tissues. While estrogen is traditionally associated with reproduction and sexual behavior in females,
Dusti A. Shay, Victoria J. Vieira-Potter, Cheryl S. Rosenfeld, Cheryl S. Rosenfeld, Cheryl S. Rosenfeld   +4 more
doaj   +1 more source

Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17beta-estradiol): Support for the demasculinization/feminization hypothesis. [PDF]

, 2006
Atrazine is a potent endocrine disruptor that both chemically castrates and feminizes male amphibians. It depletes androgens in adult frogs and reduces androgen-dependent growth of the larynx in developing male larvae.
Collins, Atif, HAYES, Tyrone, Johnston, Gwynne, Kpodzo, Dzifa, Liu, Roger, Mendoza, Magdalena, Noriega, Nigel, Stuart, A, Vonk, Aaron   +8 more
core   +2 more sources

Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner

Frontiers in Neuroscience, 2020
The enzyme aromatase catalyzes the final step in estrogen biosynthesis, converting testosterone to estradiol, and is expressed in the brain of all mammals.
Nelly Alia-Klein, Rebecca N. Preston-Campbell, Sung Won Kim, Deborah Pareto, Jean Logan, Gene-Jack Wang, Scott J. Moeller, Joanna S. Fowler, Anat Biegon   +8 more
doaj   +1 more source

A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]

, 2011
Background The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.
Wang, J.Z., Deogan, M.S., Lewis, J.R., Chew, S., Mullin, B.H., McNab, T.J., Wilson, S.G., Ingley, E., Prince, R.L.   +8 more
core   +3 more sources

Life-history and hormonal control of aggression in black redstarts: blocking testosterone does not decrease territorial aggression, but changes the emphasis of vocal behaviours during simulated territorial intrusions [PDF]

, 2013
Introduction: Many studies in behavioural endocrinology attempt to link territorial aggression with testosterone, but the exact relationship between testosterone and territorial behaviour is still unclear and may depend on the ecology of a species.
Apfelbeck, Beate, Goymann, Wolfgang, Kiefer, Sarah, Kipper, Silke, Mortega, Kim G   +4 more
core   +2 more sources

In situ aromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancer

BMC Cancer, 2009
Background New, third-generation aromatase inhibitors (AIs) have proven comparable or superior to the anti-estrogen tamoxifen for treatment of estrogen receptor (ER) and/or progesterone receptor (PR) positive breast cancer.
Lykkesfeldt Anne E, Henriksen Katrine L, Rasmussen Birgitte B, Sasano Hironobu, Evans Dean B, Møller Susanne, Ejlertsen Bent, Mouridsen Henning T   +7 more
doaj   +1 more source

Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus

European Journal of Histochemistry, 2020
The goal of this study was to evaluate P450 aromatase localization in the epididymis of two different vertebrates: the lizard Podarcis sicula, a seasonal breeder, and Rattus rattus, a continuous breeder.
Luigi Rosati, Marina Prisco, Mariana Di Lorenzo, Maria De Falco, Piero Andreuccetti   +4 more
doaj   +1 more source

Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle. [PDF]

, 2017
BackgroundThe synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex ...
Assis Neto, Antônio Chaves de, Conley, Alan James, de Oliveira, Moacir Franco, Dos Santos, Amilton Cesar, Oliveira, Gleidson Benevides, Viana, Diego Carvalho   +5 more
core   +1 more source