Results 21 to 30 of about 58,906 (283)

Molecular docking studies of Alpinia galanga metabolites against human placental aromatase for estrogen-dependent breast cancer treatment [PDF]

, 2022
Breast cancer is the leading cause of cancer-related deaths among women. With the clinical success of several synthetic aromatase inhibitors (AIs) as therapeutic agents in post-menopausal estrogen receptor-positive breast cancer, natural products have ...
CECIL LAURENCE III, CRUZ, JOE ANTHONY, MANZANO, ALLAN PATRICK, MACABEO   +2 more
core   +1 more source

Mammalian sperm quality and aromatase expression [PDF]

, 2009
SynthèseInternational audienceIn most mammalian species the aromatase is encoded by a single gene (cyp19), which contains 18 exons, 9 of them being translated.
Delalande, Christelle, Christelle Delalande, Serge Carreau, Isabelle Galeraud‐Denis, Carreau, Serge, Galeraud-Denis, Isabelle   +5 more
core   +1 more source

Cloning of brain aromatase gene and expression of brain and ovarian aromatase genes during sexual differentiation in genetic male and female Nile tilapia Oreochromis niloticus [PDF]

, 2001
A brain aromatase gene was identified from the Nile tilapia Oreochromis niloticus. The cDNA sequence of this gene differed from that of the ovarian aromatase gene previously reported from this species.
Penman, David, Kwon, Joon Yeong, McAndrew, Brendan   +2 more
core   +1 more source

Does GPER1 Play a Role in Sexual Dimorphism?

Frontiers in Endocrinology, 2020
Estrogens are critical in driving sex-typical social behaviours that are ethologically relevant in mammals. This is due to both production of local estrogens and signaling by these ligands, particularly in an interconnected set of nuclei called the ...
Janine L. Dovey, Nandini Vasudevan
doaj   +1 more source

Gene Expression and Epigenetic Modification of Aromatase during Sex Reversal and Gonadal Development in Blotched Snakehead (Channa maculata)

Fishes, 2023
The cyp19a1 gene codes aromatase that converts androgen to estrogen, which plays a central role in early female differentiation and ovarian development in teleosts.
Sujing Huang, Yuxia Wu, Kunci Chen, Xiaotian Zhang, Jian Zhao, Qing Luo, Haiyang Liu, Fang Wang, Kaibin Li, Shuzhan Fei, Xincheng Zhang, Mi Ou   +11 more
doaj   +1 more source

Pyridine C─N Transposition via Cycloaddition–Cycloreversion

Angewandte Chemie, EarlyView.
Transposition of pyridine nitrogen from the 4‐ to the 3‐position is described using two open and shut sequences: a nucleophile addition ring‐open ring‐closure, followed by a nitrile Diels–Alder cycloaddition cycloreversion. The nitrogen swap is particularly effective for tertiary alkyl substituents, transforming easily accessible para‐alkylated ...
Aífe Conboy, Michael F. Greaney
wiley   +2 more sources

Development and Characterization of Inducible Astrocyte-Specific Aromatase Knockout Mice

Biology, 2023
17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for studying brain-derived E2 include global and conditional non-inducible knockout mouse models.
Jing Wang, Uday P. Pratap, Yujiao Lu, Gangadhara R. Sareddy, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Darrell W. Brann   +6 more
doaj   +1 more source

A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]

, 2011
Background The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.
Mullin, B., Ingley Evan, Lewis, J., Evan Ingley, Wilson Scott G, McNab, Tegan, Jenny Z Wang, Wang, J., Wang, J.Z., Deogan, M.S., Prince, R.L., McNab Tegan J, Ben H Mullin, Chew Shelby, McNab, T.J., Chew, S., Wang Jenny Z, Mandeep S Deogan, Richard L Prince, Mullin Ben H, Scott G Wilson, Tegan J McNab, Lewis, J.R., Prince, R., Ingley, E., Prince Richard L, Deogan Mandeep S, Deogan, M., Wilson, S., Wilson, S.G., Mullin, B.H., Lewis Joshua R, Shelby Chew, Joshua R Lewis   +33 more
core   +2 more sources

Inhibition of cytochrome p450 brain aromatase reduces two male specific sexual behaviours in the male Endler guppy (Poecilia reticulata) [PDF]

, 2006
In mammalian and avian vertebrate groups, androgens act as controlling agents on male aggression and courtship behaviour by their conversion to oestrogens by cytochrome P450 aromatase in well-defined brain regions.
Olsén, Håkan,, Hallgren, Stefan,, Olsén, K Håkan,, Linderoth, Maria, Linderoth, Maria,, Hallgren, Stefan L E,   +5 more
core   +1 more source

Design of Novel Letrozole Analogues Targeting Aromatase for Breast Cancer: Molecular Docking, Molecular Dynamics, and Theoretical Studies on Gold Nanoparticles

Metabolites, 2023
The use of aromatase inhibitors is an established therapy for estrogen-dependent breast cancer in postmenopausal women. However, the only commercially available aromatase inhibitor, letrozole, is not highly selective; in addition to aromatase, it has an ...
Alaa Edris, Mohammed Abdelrahman, Wadah Osman, Asmaa E. Sherif, Ahmed Ashour, Elrashied A. E. Garelnabi, Sabrin R. M. Ibrahim, Rawan Bafail, Waad A. Samman, Kholoud F. Ghazawi, Gamal A. Mohamed, Abdulrahim A. Alzain   +11 more
doaj   +1 more source