Results 21 to 30 of about 47,644 (242)

Potential utility of natural products as regulators of breast cancer-associated aromatase promoters

Reproductive Biology and Endocrinology, 2011
Aromatase, the key enzyme in estrogen biosynthesis, converts androstenedione to estrone and testosterone to estradiol. The enzyme is expressed in various tissues such as ovary, placenta, bone, brain, skin, and adipose tissue.
Walker Larry A, Khan Ikhlas A, Zhao Jianping, Khan Shabana I, Dasmahapatra Asok K   +4 more
doaj   +1 more source

Computational method for aromatase-related proteins using machine learning approach.

PLoS ONE, 2023
Human aromatase enzyme is a microsomal cytochrome P450 and catalyzes aromatization of androgens into estrogens during steroidogenesis. For breast cancer therapy, third-generation aromatase inhibitors (AIs) have proven to be effective; however patients ...
Muthu Krishnan Selvaraj, Jasmeet Kaur
doaj   +1 more source

PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs

Scientific Reports, 2021
Aromatase is an estrogen synthetic enzyme that plays important roles in brain functions. To quantify aromatase expression in the brain by positron emission tomography (PET), we had previously developed [11C]cetrozole, which showed high specificity and ...
Kayo Takahashi, Takamitsu Hosoya, Kayo Onoe, Tomoko Mori, Shusaku Tazawa, Aya Mawatari, Yasuhiro Wada, Yumiko Watanabe, Hisashi Doi, Yasuyoshi Watanabe   +9 more
doaj   +1 more source

Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses

Frontiers in Molecular Neuroscience, 2018
Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase is expressed in the testes, ovaries, brain, and other tissues. While estrogen is traditionally associated with reproduction and sexual behavior in females,
Dusti A. Shay, Victoria J. Vieira-Potter, Cheryl S. Rosenfeld, Cheryl S. Rosenfeld, Cheryl S. Rosenfeld   +4 more
doaj   +1 more source

The effect of third-generation aromatase inhibitors on aromatase avtivity in visceral adipose tissue

Regulatory Mechanisms in Biosystems, 2018
Pathogenesis and clinical manifestations of metabolic syndrome (and other conditions characterized by the growth of fat mass and decreased adiponectin content) is associated with an imbalance of sex hormones, which develops under the influence of ...
D. V. Lytkin, A. L. Zagayko, T. O. Briukhanova   +2 more
doaj   +1 more source

Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner

Frontiers in Neuroscience, 2020
The enzyme aromatase catalyzes the final step in estrogen biosynthesis, converting testosterone to estradiol, and is expressed in the brain of all mammals.
Nelly Alia-Klein, Rebecca N. Preston-Campbell, Sung Won Kim, Deborah Pareto, Jean Logan, Gene-Jack Wang, Scott J. Moeller, Joanna S. Fowler, Anat Biegon   +8 more
doaj   +1 more source

In situ aromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancer

BMC Cancer, 2009
Background New, third-generation aromatase inhibitors (AIs) have proven comparable or superior to the anti-estrogen tamoxifen for treatment of estrogen receptor (ER) and/or progesterone receptor (PR) positive breast cancer.
Lykkesfeldt Anne E, Henriksen Katrine L, Rasmussen Birgitte B, Sasano Hironobu, Evans Dean B, Møller Susanne, Ejlertsen Bent, Mouridsen Henning T   +7 more
doaj   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

Does GPER1 Play a Role in Sexual Dimorphism?

Frontiers in Endocrinology, 2020
Estrogens are critical in driving sex-typical social behaviours that are ethologically relevant in mammals. This is due to both production of local estrogens and signaling by these ligands, particularly in an interconnected set of nuclei called the ...
Janine L. Dovey, Nandini Vasudevan
doaj   +1 more source

Gene Expression and Epigenetic Modification of Aromatase during Sex Reversal and Gonadal Development in Blotched Snakehead (Channa maculata)

Fishes, 2023
The cyp19a1 gene codes aromatase that converts androgen to estrogen, which plays a central role in early female differentiation and ovarian development in teleosts.
Sujing Huang, Yuxia Wu, Kunci Chen, Xiaotian Zhang, Jian Zhao, Qing Luo, Haiyang Liu, Fang Wang, Kaibin Li, Shuzhan Fei, Xincheng Zhang, Mi Ou   +11 more
doaj   +1 more source