Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials [PDF]
Lancet, The, 2015 BACKGROUND: The optimal ways of using aromatase inhibitors or tamoxifen as endocrine treatment for early breast cancer remains uncertain.METHODS: We undertook meta-analyses of individual data on 31 920 postmenopausal women with oestrogen-receptor ...
, Clarke, Michael
core +6 more sources
A radiation recall phenomenon induced by aromatase inhibitors
Current Problems in Cancer: Case Reports, 2021 Radiation recall phenomena induced by aromatase inhibitors have been poorly reported to the literature.We hereby report the case of an 85-year-old woman who presented a cutaneous recall reaction to letrozole (Femara©), one month after the end of ...
Sabrine Slimani +5 more
doaj +1 more source
The Role of Phorbol Diesters in Mediating Human Placental Aromatase Cytochrome P450 Activity
Applied Biosciences, 2022 Due to the aromatase enzyme’s involvement in estrogen biosynthesis, aromatase inhibitors have emerged as the preferred treatment for postmenopausal women with ER+ breast cancer.
Chiemela S. Odoemelam +6 more
doaj +1 more source
Preparation of a novel antiserum to aromatase with high affinity and specificity: Its clinicopathological significance on breast cancer tissue. [PDF]
PLoS ONE, 2017 Aromatase inhibitors have been widely used for the endocrine treatment of estrogen-dependent breast cancer in postmenopausal patients. However, clinicopathological studies of aromatase have been limited due to unsatisfactory specificity and/or restricted
Naoki Kanomata +6 more
doaj +1 more source
Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme
Molecules, 2023 CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resistance
Tenzin Adon +6 more
doaj +1 more source
Aromatase, aromatase inhibitors, and breast cancer [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2011 Estrogens are known to be important in the growth of breast cancers in both pre and postmenopausal women. As the number of breast cancer patients increases with age, the majority of breast cancer patients are postmenopausal women. Although estrogens are no longer made in the ovaries after menopause, peripheral tissues produce sufficient concentrations ...
Saranya, Chumsri +4 more
openaire +2 more sources
The Aromatase–Estrogen System in the Testes of Non-Mammalian Vertebrates
Animals, 2021 Estrogens are important physiological regulators of testicular activity in vertebrates. Estrogen levels depend on the activity of P450 aromatase, the enzyme responsible for the irreversible conversion of testosterone into 17β-estradiol.
Luigi Rosati +4 more
doaj +1 more source
The effect of third-generation aromatase inhibitors on aromatase avtivity in visceral adipose tissue
Regulatory Mechanisms in Biosystems, 2018 Pathogenesis and clinical manifestations of metabolic syndrome (and other conditions characterized by the growth of fat mass and decreased adiponectin content) is associated with an imbalance of sex hormones, which develops under the influence of ...
D. V. Lytkin +2 more
doaj +1 more source
Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model [PDF]
, 2016 Purpose Phosphodiesterase type-5 inhibitor (PDE5i) tadalafil administration in men with erectile dysfunction is associated with increased testosterone/estradiol ratio, leading to hypothesize a potential increased effect of androgen action on target ...
Aversa, Antonio +8 more
core +1 more source
Neoadjuvant endocrine therapy for luminal breast cancer treatment: a first-choice alternative in times of crisis such as the COVID-19 pandemic [PDF]
, 2020 The epidemiological emergency caused by CoV-2 (COVID-19) has changed priorities in breast cancer management. In those places where the pandemic has had the greatest effect, it is of paramount importance for most patients to be at home, reducing or ...
Martí, Covadonga +1 more
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