AROMATASE INHIBITORS - TYPES AND ADVANTAGES [PDF]
, 2016 The role of aromatase inhibitors in the management of breast cancer has been promising as it markedly suppresses the production of estrogen. The inhibitors are very effective in postmenopausal women and used as the first line therapy for hormone ...
C., Sudandiradoss, C., Benedict Paul
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Aromatase Inhibitors for Ovulation Induction [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2015 Normogonadotropic anovulation, including polycystic ovary syndrome (PCOS), is one of the main causes of infertility. Recent meta-analysis and randomized controlled trial suggest the use of aromatase inhibitors (ie, letrozole) as effective drug and first-line treatment to restore fertility in these patients.
openaire +3 more sources
Toxicology Reports, 2017 Naturally occurring depsidones from the marine fungus Aspergillus unguis are known to have substantial anti-cancer activity, but their mechanism of action remains elusive. The purpose of this study was to examine the anti-aromatase activity of two common
Suthat Chottanapund +8 more
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Evaluation of Inhibitory Effect and Docking Study of Triazolyl Chromanone Oxime Ether Derivatives on Aromatase Enzyme Effective in Breast Cancer [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: The spread of cancer, coupled with the challenges posed by complex treatments, stands as one of the foremost medical issues in today's world.
Roshanak Hariri +5 more
doaj
Aromatase Inhibitors in the Treatment of Endometriosis
, 2011 Current treatment of endometriosis is mainly based on surgery and ovarian suppressive agents. In the last 10 years, it has been demonstrated that aromatase P450, a key enzyme for estrogen biosynthesis, may have a pathogenic role in endometriosis because ...
Remorgida V, Ferrero S, Venturini PL
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Facile Synthesis of Chrysin-derivatives with Promising Activities as Aromatase Inhibitors
Natural Product Communications, 2011 Flavones such as chrysin show structural similarities to androgens, the substrates of human aromatase, which converts androgens to estrogens. Aromatase is a key target in the treatment of hormone-dependent tumors, including breast cancer.
Hamdoon A. Mohammed +10 more
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The emerging use of aromatase inhibitors for endometriosis treatment
Reproductive Biology and Endocrinology, 2011 Endometriosis is defined as the growth of endometrial tissue outside of the uterine cavity. The disease occurs primarily in women of reproductive age but recurrent endometriosis is also detected in post-menopausal women.
Nothnick Warren B
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Study of Aromatase-Catalyzed Metabolic Switching of 2,2-Dimethylandrostenedione : Synthesis of Possible Metabolites and Their Inhibitory Activities of Aromatase [PDF]
, 2004 Aromatase is a cytochrome P-450 enzyme responsible for the conversion of androgens to estrogens. 2,2-Dimethylandrostenedione (5) is one of the powerful inhibitors of the enzyme.
山田, 恵子 +11 more
core
Медицинский совет, 2018 Aromatase inhibitor (AI) combined with Gonadotropin-releasing hormone agonist (GnRH-a) have been recognized as an effective approach to adjuvant endocrinotherapy for breast cancer (BC) in premenopausal patients with adverse predictive factors.
I. B. Kononenko +4 more
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A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]
, 2011 Background The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.
Mullin, B. +33 more
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