A radiation recall phenomenon induced by aromatase inhibitors
Current Problems in Cancer: Case Reports, 2021 Radiation recall phenomena induced by aromatase inhibitors have been poorly reported to the literature.We hereby report the case of an 85-year-old woman who presented a cutaneous recall reaction to letrozole (Femara©), one month after the end of ...
Sabrine Slimani +5 more
doaj +1 more source
The Role of Phorbol Diesters in Mediating Human Placental Aromatase Cytochrome P450 Activity
Applied Biosciences, 2022 Due to the aromatase enzyme’s involvement in estrogen biosynthesis, aromatase inhibitors have emerged as the preferred treatment for postmenopausal women with ER+ breast cancer.
Chiemela S. Odoemelam +6 more
doaj +1 more source
Preparation of a novel antiserum to aromatase with high affinity and specificity: Its clinicopathological significance on breast cancer tissue. [PDF]
PLoS ONE, 2017 Aromatase inhibitors have been widely used for the endocrine treatment of estrogen-dependent breast cancer in postmenopausal patients. However, clinicopathological studies of aromatase have been limited due to unsatisfactory specificity and/or restricted
Naoki Kanomata +6 more
doaj +1 more source
Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme
Molecules, 2023 CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resistance
Tenzin Adon +6 more
doaj +1 more source
Are differences in the available aromatase inhibitors and inactivators significant?
, 2001 Aromatase inhibitors are endocrine agents with a different mode of action than tamoxifen against breast tumors. In postmenopausal women, estrogen concentrations are maintained primarily via aromatase, a cytochrome P-450 enzyme that acts at the final step
Arteaga, C. +10 more
core +10 more sources
The Aromatase–Estrogen System in the Testes of Non-Mammalian Vertebrates
Animals, 2021 Estrogens are important physiological regulators of testicular activity in vertebrates. Estrogen levels depend on the activity of P450 aromatase, the enzyme responsible for the irreversible conversion of testosterone into 17β-estradiol.
Luigi Rosati +4 more
doaj +1 more source
Effect of anastrozole on bone mineral density and lipid profiles when used to prevent breast cancer in high risk postmenopausal women [PDF]
, 2012 PhDThe role of aromatase inhibitors (AIs) in breast cancer has expanded since their introduction in the mid-1990s. They are superior to tamoxifen in the treatment of postmenopausal women with oestrogen dependant tumours in the metastatic, neoadjuvant ...
Singh, Shalini
core +4 more sources
Aromatase inhibitors in male: A literature review
Medicina Clínica Práctica, 2023 Aromatase (CYP19A1) is a monooxygenase from the family of cytochrome P450 that plays role in the androgens to estrogens conversion. Aromatase inhibitors prohibit the aromatase enzyme function.
Mohsen Korani
doaj +1 more source
Preventative therapies for healthy women at high risk of breast cancer [PDF]
, 2014 Ivana Sestak Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UKAbstract: Tamoxifen has been shown to reduce the risk of developing estrogen receptor (ER)-positive ...
Sestak I, Sestak, I
core +1 more source
Biomedicine & Pharmacotherapy, 2007 Aromatase is a key enzyme of intratumoral production of estrogen in breast cancers. Aromatase inhibitors are commonly used as hormone therapy in postmenopausal estrogen sensitive breast cancer patients. Type I aromatase inhibitors such as exemestane are steroidal inhibitors, which have androstenedione like structure and bind to androgen receptor with ...
Yasuhiro, Miki +2 more
openaire +2 more sources