Results 31 to 40 of about 644,370 (183)

Possibilities of immunogistochemical investigation in respons prognosis to treatment and modification of treatment activities at luminal breast cancer (literature review).

Medičnì Perspektivi, 2017
This article is concerned with both standard (estrogen and progesterone receptors, Her2/neu and Ki67) immu­nohistochemical investigation in hormonal therapy tactics decision for luminal breast cancer and additional in­vestigation of such hormonal ...
I. M. Bondarenko, V. F. Zavizion, M. V. Artemenko, M. I. Hojouj, L. O. Maltseva, І. V. Bilenkyi, V. А. Hurtovyi, V. V. Lohvynenko, A. V. Prokhach   +8 more
doaj   +1 more source

AROMATASE INHIBITORS-TYPES AND ADVANTAGES [PDF]

, 2020
The role of aromatase inhibitors in the management of breast cancer has been promising as it markedly suppresses the production of estrogen. The inhibitors are very effective in postmenopausal women and used as the first-line therapy for hormone ...
C., SUDANDIRADOSS, C., BENEDICT PAUL
core   +1 more source

Dual aromatase-steroid sulfatase inhibitors

, 2007
By introducting the steroid sulfatase inhibitory pharmacophore into aromatase inhibitor 1 (YM511), two series of single agent dual aromatase-sulfatase inhibitors (DASIs) were generated. The best DASIs in vitro (JEG-3 cells) are 5, (IC50(aromatase) = 0.82
Chander, S.K., Purohit, A., Mahon, M.F., Bubert, C., Smith, A., Potter, B.V.L., Reed, M.J., Sutcliffe, O.B., Woo, L.W.L.   +8 more
core   +4 more sources

Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis

Reproductive Biology and Endocrinology, 2011
Background The present study compares antiepileptic drugs and aromatase (CYP19) inhibitors for chemical and structural similarity. Human aromatase is well known as an important pharmacological target in anti-breast cancer therapy, but recent research ...
Mustata Gabriela, Muftuoglu Yagmur
doaj   +1 more source

Role of aromatase inhibitors in breast cancer [PDF]

, 2005
Primarily, the role of the aromatase inhibitors has been investigated in postmenopausal women with breast cancer, although it is also now being assessed in premenopausal patients following ovarian ablation/suppression.
Carpenter, R, W R Miller, Miller, W R, R Carpenter   +3 more
core   +1 more source

Locally Advanced Breast Cancer Patient’s Recurrence Rates Comparison Received Steroidal and Nonsteroidal Aromatase Inhibitor Based on Luminal

Biomolecular and Health Science Journal
Introduction: Aromatase inhibitors are hormonal therapies used in menopausal breast cancer with positive progesterone receptors and/or estrogen receptors.
Desak Gede Agung Suprabawati, Bernadeta Hernik Setiyandari, Dwi Hari Susilo, Bara Kharisma, Rizki Amalia   +4 more
doaj   +1 more source

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity

Molecules, 2023
A novel series of 1,2,3-triazole/1,2,4-triazole hybrids 5a, 5b, and 6a–i was designed and synthesized as antiproliferative agents targeting aromatase enzymes.
Mohamed T-E Maghraby, Tahani Mazyad Almutairi, Stefan Bräse, Ola I. A. Salem, Bahaa G. M. Youssif, Mahmoud M. Sheha   +5 more
doaj   +1 more source

Sequencing of aromatase inhibitors [PDF]

British Journal of Cancer, 2005
Since the development of the third-generation aromatase inhibitors (AIs), anastrozole, letrozole and exemestane, these agents have been the subject of intensive research to determine their optimal use in advanced breast cancer. Not only have they replaced progestins in second-line therapy and challenged the role of tamoxifen in first-line, but there is
openaire   +2 more sources

A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility

Asian Journal of Andrology, 2020
Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.
Francesco Del Giudice, Gian Maria Busetto, Ettore De Berardinis, Isabella Sperduti, Matteo Ferro, Martina Maggi, Martin S Gross, Alessandro Sciarra, Michael L Eisenberg   +8 more
doaj   +1 more source

Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs

Molecules
Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are hormones that contribute to the growth of certain types of breast cancer.
Sara Janowska, Serhii Holota, Roman Lesyk, Monika Wujec   +3 more
doaj   +1 more source