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Seasonal dynamics, sources, and ecological risk of estrogens in a freeze-thaw basin: Implications for aquatic ecosystems

Ecotoxicology and Environmental Safety
Estrogens have attracted extensive attention because of their harmful effects on organisms such as endocrine disturbance and reproductive toxicity. This study investigated the spatial and temporal distribution and ecological risk assessment of 7 targeted
Jiamei Wang, Tianzhi Li, Wei Ouyang, Xin Hao, Yan Bai, Shangwei Zhang, Chunye Lin, Mengchang He, Xitao Liu   +8 more
doaj   +1 more source

Estrogens and Androgens in Plants: The Last 20 Years of Studies

Plants, 2021
Although the only known steroid hormones in plants are brassinosteroids, interestingly, mammalian steroid hormones such as androgens or estrogens are also part of the plant metabolic profile. This presented review is focused on the progress that has been
Anna Janeczko
doaj   +1 more source

Roles of Estrogens in the Healthy and Diseased Oviparous Vertebrate Liver

Metabolites, 2021
The liver is a vital organ that sustains multiple functions beneficial for the whole organism. It is sexually dimorphic, presenting sex-biased gene expression with implications for the phenotypic differences between males and females.
Blandine Tramunt, Alexandra Montagner, Nguan Soon Tan, Pierre Gourdy, Hervé Rémignon, Walter Wahli   +5 more
doaj   +1 more source

The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens

Biomedicines
The role of estrogens in prostate cancer (PCa) is shrouded in mystery, with its actions going from angelic to devilish. The findings by Huggins and Hodges establishing PCa as a hormone-sensitive cancer have provided the basis for using estrogens in ...
Marília I. Figueira, Tiago M. A. Carvalho, Joana Macário-Monteiro, Henrique J. Cardoso, Sara Correia, Cátia V. Vaz, Ana P. Duarte, Sílvia Socorro   +7 more
doaj   +1 more source

Equine estrogens differentially inhibit DNA fragmentation induced by glutamate in neuronal cells by modulation of regulatory proteins involved in programmed cell death

BMC Neuroscience, 2003
Background Recent data indicate that excitotoxicity of high levels of neurotransmitter glutamate may be mediated via programmed cell death (apoptosis) and that it can be prevented in HT22 mouse hippocampal cells by various equine estrogens with Δ8,17β ...
Lu XiaoFeng, Zhang YueMei, Bhavnani Bhagu R   +2 more
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Metabolomic profiling unravels DNA adducts in human breast that are formed from peroxidase mediated activation of estrogens to quinone methides. [PDF]

PLoS ONE, 2013
Currently there are three major hypotheses that have been proposed for estrogen induced carcinogenicity, however exact etiology remains unknown. Based on the chemical logic, studies were undertaken to investigate if estrogens could generate quinone ...
Nilesh W Gaikwad
doaj   +1 more source

Estrogens and Stem Cells in Thyroid Cancer

Frontiers in Endocrinology, 2014
Recent discoveries highlight the emerging role of estrogens in the initiation and progression of different malignancies through their interaction with stem cell compartment.
Mariangela eZane, Mariangela eZane, Veronica eCatalano, Emanuela eScavo, Marco eBonanno, Maria Rosa Pelizzo, Matilde eTodaro, Giorgio eStassi   +7 more
doaj   +1 more source

Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka

eLife
In rodents, estrogens aromatized from androgens in the brain are essential for the development of male-typical behaviors. In many other vertebrates, including humans and teleost fish, however, androgens facilitate these behaviors directly via the ...
Yuji Nishiike, Shizuku Maki, Daichi Miyazoe, Kiyoshi Nakasone, Yasuhiro Kamei, Takeshi Todo, Tomoko Ishikawa-Fujiwara, Kaoru Ohno, Takeshi Usami, Yoshitaka Nagahama, Kataaki Okubo   +10 more
doaj   +1 more source

Desenvolvimento de metodologia para avaliar remoção de estrogênios em estações de tratamento de esgotos

Química Nova, 2012
The present research aimed to study the parameters that affect the determination of estrogens in sewage upon the use of SPE and determination by using gas chromatography mass spectrometry (GC/MS).
Germana de Paiva Pessoa, André Bezerra dos Santos, Neyliane Costa de Souza, Joana Angélica Correia Alves, Ronaldo Ferreira do Nascimento   +4 more
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The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031

Biomolecules, 2021
Inhibition of K+-conductance through the human ether-a-go-go related gene (hERG) channel leads to QT prolongation and is associated with cardiac arrhythmias.
Fumiya Tamura, Shintaro Sugimoto, Mana Sugimoto, Kazuho Sakamoto, Masahiko Yamaguchi, Takeshi Suzuki, Keiichi Fukuda, Masaki Ieda, Junko Kurokawa   +8 more
doaj   +1 more source