Results 31 to 40 of about 82,387 (308)

Molecular mechanism of estrogen–estrogen receptor signaling [PDF]

Reproductive Medicine and Biology, 2016
Abstract17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ERβ that are encoded by distinct genes.
Yasar, Pelin, Ayaz, Gamze, User, Sirma Damla, Gupur, Gizem, Muyan, Mesut   +4 more
openaire   +3 more sources

Estrogenic Activities in Rodent Estrogen-Free Diets [PDF]

Endocrinology, 2005
Diets lacking soy and alpha-alpha derivatives that are considered to be estrogen-free by standard bioassays (uterotrophic assay and vaginal opening) have been revealed to contain considerable amounts of compounds able to transcriptionally activate the estrogen receptors (ERs) and stimulate luciferase expression in several organs of the ERE-Luc reporter
P. Ciana, A. Brena, P. Sparaciari, E. Bonetti, D. Di Lorenzo, A. Maggi   +5 more
openaire   +3 more sources

Algal extracellular organic matter mediated photocatalytic degradation of estrogens

Ecotoxicology and Environmental Safety, 2021
Estrogens are among the most concerned emerging contaminants in the wastewater treatment effluent due to their sexual disruption in aquatic wildlife. The use of microalgae for secondary wastewater effluent polishing is a promising approach due to the ...
Pei-Hsun Wu, Hsin-Yi Yeh, Pei-Hsin Chou, Wen-Wei Hsiao, Chang-Ping Yu   +4 more
doaj   +1 more source

Roles of Estrogens in the Healthy and Diseased Oviparous Vertebrate Liver

Metabolites, 2021
The liver is a vital organ that sustains multiple functions beneficial for the whole organism. It is sexually dimorphic, presenting sex-biased gene expression with implications for the phenotypic differences between males and females.
Blandine Tramunt, Alexandra Montagner, Nguan Soon Tan, Pierre Gourdy, Hervé Rémignon, Walter Wahli   +5 more
doaj   +1 more source

Seasonal dynamics, sources, and ecological risk of estrogens in a freeze-thaw basin: Implications for aquatic ecosystems

Ecotoxicology and Environmental Safety
Estrogens have attracted extensive attention because of their harmful effects on organisms such as endocrine disturbance and reproductive toxicity. This study investigated the spatial and temporal distribution and ecological risk assessment of 7 targeted
Jiamei Wang, Tianzhi Li, Wei Ouyang, Xin Hao, Yan Bai, Shangwei Zhang, Chunye Lin, Mengchang He, Xitao Liu   +8 more
doaj   +1 more source

Estrogens and Androgens in Plants: The Last 20 Years of Studies

Plants, 2021
Although the only known steroid hormones in plants are brassinosteroids, interestingly, mammalian steroid hormones such as androgens or estrogens are also part of the plant metabolic profile. This presented review is focused on the progress that has been
Anna Janeczko
doaj   +1 more source

Predicted exposures to steroid estrogens in U.K. rivers correlate with widespread sexual distruption in wild fish populations

, 2005
Steroidal estrogens, originating principally from human excretion, are likely to play a major role in causing widespread endocrine disruption in wild populations of the roach (Rutilus rutilus) , a common cyprinid fish, in rivers contaminated by treated ...
Ronny van Aerle, Nolan, Monique, Nolan, M, Ayesha Taylor, Susan Jobling, Jobling, Susan, Jobling, S, Santos, E, Brighty, Geoff, Johnson, Andrew, Tyler, CR, Charles R. Tyler, Taylor, Ayesha, Andrew Johnson, Gross-Sorokin, M, Taylor, A, Williams, Richard, Santos, Eduarda, van Aerle, R, Richard Williams, Brighty, G, Geoff Brighty, Eduarda Santos, Williams, R, Aerle, RV, Gross-Sorokin, Melanie, Tyler, Charles R, Johnson, A, Melanie Gross-Sorokin, Monique Nolan, van Aerie, Ronny   +30 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Disruption of 3D MCF-12A breast cell cultures by estrogens - An in vitro model for ER-mediated changes indicative of hormonal carcinogenesis

, 2012
Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source
Stephanie Marchese, Elisabete Silva, Silva, E, Marchese, S, Marchese Stephanie, Silva Elisabete   +5 more
core   +1 more source

Metabolomic profiling unravels DNA adducts in human breast that are formed from peroxidase mediated activation of estrogens to quinone methides. [PDF]

PLoS ONE, 2013
Currently there are three major hypotheses that have been proposed for estrogen induced carcinogenicity, however exact etiology remains unknown. Based on the chemical logic, studies were undertaken to investigate if estrogens could generate quinone ...
Nilesh W Gaikwad
doaj   +1 more source