Results 41 to 50 of about 66,352 (263)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Estrogen and Spermatogenesis* [PDF]

Endocrine Reviews, 2001
AbstractAlthough it has been known for many years that estrogen administration has deleterious effects on male fertility, data from transgenic mice deficient in estrogen receptors or aromatase point to an essential physiological role for estrogen in male fertility.
L, O'Donnell, K M, Robertson, M E, Jones, E R, Simpson   +3 more
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Signaling by estrogens [PDF]

Journal of Cellular Physiology, 2007
AbstractBy regulating activities and expression levels of key signaling molecules, estrogens control mechanisms that are responsible for crucial cellular functions. Ligand binding to estrogen receptor (ER) leads to conformational changes that regulate the receptor activity, its interaction with other proteins and DNA.
Boris J, Cheskis, James G, Greger, Sunil, Nagpal, Leonard P, Freedman   +3 more
openaire   +2 more sources

Desenvolvimento de metodologia para avaliar remoção de estrogênios em estações de tratamento de esgotos

Química Nova, 2012
The present research aimed to study the parameters that affect the determination of estrogens in sewage upon the use of SPE and determination by using gas chromatography mass spectrometry (GC/MS).
Germana de Paiva Pessoa, André Bezerra dos Santos, Neyliane Costa de Souza, Joana Angélica Correia Alves, Ronaldo Ferreira do Nascimento   +4 more
doaj   +1 more source

The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031

Biomolecules, 2021
Inhibition of K+-conductance through the human ether-a-go-go related gene (hERG) channel leads to QT prolongation and is associated with cardiac arrhythmias.
Fumiya Tamura, Shintaro Sugimoto, Mana Sugimoto, Kazuho Sakamoto, Masahiko Yamaguchi, Takeshi Suzuki, Keiichi Fukuda, Masaki Ieda, Junko Kurokawa   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Potassium, magnesium and pyridoxine in the context of the biological effects of estrogens [PDF]

Гинекология, 2017
Potassium and magnesium ions are essential for realizing the biological effects of estrogens. Magnesium ions promote the translocation of the estrogen receptors into the nucleus of the cell and regulate the potassium channels that are involved in the ...
O A Gromova, I Yu Torshin, I K Tomilova, L K Dzhidzhikhiya, N V Kerimkulova   +4 more
doaj  

Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry

Data in Brief, 2019
Analysis of catechol estrogens (2 & 4 hydroxy-estrone and estradiol) has proven troublesome by liquid chromatography tandem mass spectrometry due to their low concentrations, short half-lives and temperature-labile nature.
Nina Denver, Shazia Khan, Ioannis Stasinopoulos, Colin Church, Natalie Z.M. Homer, Margaret R. MacLean, Ruth Andrew   +6 more
doaj   +1 more source

Metabolic alteration of circulating steroid hormones in women with gestational diabetes mellitus and the related risk factors

Frontiers in Endocrinology, 2023
BackgroundAbnormally changed steroid hormones during pregnancy are closely related to the pathological process of gestational diabetes mellitus (GDM). Our aim was to systematically profile the metabolic alteration of circulating steroid hormones in GDM ...
Na Yang, Na Yang, Wei Zhang, Cheng Ji, Jiajia Ge, Xiaoli Zhang, Meijuan Li, Min Wang, Tianqi Zhang, Jun He, Huaijun Zhu   +10 more
doaj   +1 more source