Results 11 to 20 of about 58,906 (283)
Aromatase: a neuroprotective enzyme [PDF]
Progress in Neurobiology, 2003 Estradiol, in addition to its participation in neuroendocrine regulation and sexual behavior, has neuroprotective properties. Different types of brain injury induce the expression of the enzyme aromatase in reactive astroglia. This enzyme catalyzes the conversion of testosterone and other C19 steroids to estradiol. Genetic or pharmacological inhibition
L. M. Garcia Segura +4 more
core +8 more sources
The effect of third-generation aromatase inhibitors on aromatase avtivity in visceral adipose tissue [PDF]
Regulatory Mechanisms in Biosystems, 2018 Pathogenesis and clinical manifestations of metabolic syndrome (and other conditions characterized by the growth of fat mass and decreased adiponectin content) is associated with an imbalance of sex hormones, which develops under the influence of ...
D. V. Lytkin +2 more
doaj +3 more sources
Aromatase, aromatase inhibitors, and breast cancer [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2011 Estrogens are known to be important in the growth of breast cancers in both pre and postmenopausal women. As the number of breast cancer patients increases with age, the majority of breast cancer patients are postmenopausal women. Although estrogens are no longer made in the ovaries after menopause, peripheral tissues produce sufficient concentrations ...
Saranya, Chumsri +4 more
openaire +2 more sources
Reproduction, 2001 Abstract Aromatase is the enzyme complex that catalyses the synthesis of oestrogens from androgens, and therefore it has unique potential to influence the physiological balance between the sex steroid hormones. Both aromatase cytochrome P450 (P450arom) and NADPH-cytochrome P450 reductase (reductase), the two essential components of ...
A, Conley, M, Hinshelwood
openaire +2 more sources
BJS (British Journal of Surgery), EarlyView., 2020 This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund +4 more
wiley +1 more source
Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses
Frontiers in Molecular Neuroscience, 2018 Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase is expressed in the testes, ovaries, brain, and other tissues. While estrogen is traditionally associated with reproduction and sexual behavior in females,
Dusti A. Shay +4 more
doaj +1 more source
Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner
Frontiers in Neuroscience, 2020 The enzyme aromatase catalyzes the final step in estrogen biosynthesis, converting testosterone to estradiol, and is expressed in the brain of all mammals.
Nelly Alia-Klein +8 more
doaj +1 more source
Effects on Guppy Brain Aromatase Activity Following Short-Term Steroid and 4-Nonylphenol Exposures [PDF]
, 2010 Brain estrogen production, performed by the enzyme aromatase, can be disrupted/affected in teleost fish exposed to endocrine disruptors found in polluted aquatic environments. The guppy (Poecilia reticulata) was previously studied and confirmed to suffer
Olsén, Håkan, +2 more
core +1 more source
BMC Cancer, 2009 Background New, third-generation aromatase inhibitors (AIs) have proven comparable or superior to the anti-estrogen tamoxifen for treatment of estrogen receptor (ER) and/or progesterone receptor (PR) positive breast cancer.
Lykkesfeldt Anne E +7 more
doaj +1 more source
Aromatase inhibitors in the treatment of endometriosis [PDF]
, 2016 Endometriosis is a chronic inflammatory condition in which foci of endometrial tissue grow outside of the uterine cavity. Endometriosis was estimated to affect 176 million women of childbearing potential all over the world in 2010.
Błażej Męczekalski +1 more
core +1 more source