Results 31 to 40 of about 58,906 (283)
Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice
Neural Plasticity, 2016 Numerous studies show that 17β-estradiol (E2) protects against Alzheimer’s disease (AD) induced neurodegeneration. The E2-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is
Janine Prange-Kiel +5 more
doaj +1 more source
Hormonal Homologies between Canine Mammary Cancer and Human Breast Cancer in a Series of Cases
Veterinary Sciences, 2022 The validity of spontaneous canine mammary cancer (CMC) as a natural model for the study of human breast cancer (HBC) from a hormonal point of view has never been thoroughly investigated.
Paloma Jimena de Andrés +8 more
doaj +1 more source
Estrogens and male reproduction: a new concept
Brazilian Journal of Medical and Biological Research, 2007 The mammalian testis serves two main functions: production of spermatozoa and synthesis of steroids; among them estrogens are the end products obtained from the irreversible transformation of androgens by a microsomal enzymatic complex named aromatase ...
S. Carreau +7 more
doaj +1 more source
Long-term Effect of Aromatase Inhibition in Aromatase Excess Syndrome
The Journal of Clinical Endocrinology & Metabolism, 2021 Abstract Context Aromatase excess syndrome (AEXS) is a very rare disorder characterized by prepubertal gynecomastia, bone age acceleration, and early growth arrest. Heterozygote submicroscopic rearrangements within the promotor of CYP19A1 result in overexpression of aromatase and enhanced ...
Gerhard Binder +5 more
openaire +2 more sources
Biomolecular and Health Science JournalIntroduction: Aromatase inhibitors are hormonal therapies used in menopausal breast cancer with positive progesterone receptors and/or estrogen receptors.
Desak Gede Agung Suprabawati +4 more
doaj +1 more source
Sexuality in a man with aromatase deficiency [PDF]
, 1998 The evaluation of sexual behavior in a man with aromatase deficiency explains the role of estrogen on male sexuality.
Antonio R. M. Granata +4 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Bone radiological findings in a man affected by aromatase deficiency treated with estrogens [PDF]
, 1998 Estrogen replacemente treatment in a man affected by aromatase deficiency changes bone radiological aspects leading to a fusion of the epiphyses of long bones, the latter was not achieved with the treatment of testosterone ...
Marco Faustini Fustini +4 more
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Rapid Modulation of Aromatase Activity in the Vertebrate Brain
Journal of Experimental Neuroscience, 2013 Numerous steroid hormones, including 17β-estradiol (E2), activate rapid and transient cellular, physiological, and behavioral changes in addition to their well-described genomic effects. Aromatase is the key-limiting enzyme in the production of estrogens,
Thierry D. Charlier +2 more
doaj +1 more source