Results 51 to 60 of about 94,383 (270)

Rapid Modulation of Aromatase Activity in the Vertebrate Brain

Journal of Experimental Neuroscience, 2013
Numerous steroid hormones, including 17β-estradiol (E2), activate rapid and transient cellular, physiological, and behavioral changes in addition to their well-described genomic effects. Aromatase is the key-limiting enzyme in the production of estrogens,
Thierry D. Charlier, Charlotte A. Cornil, Jacques Balthazart   +2 more
doaj   +1 more source

Influences of L-DOPA and Blocking Dopamine Receptors on Aromatase Gene Expression and Serum Concentration of LH in Rat Model of Polycystic Ovary Syndrome [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Polycystic ovary syndrome (PCOS) is associated with higher plasma levels of androgens, LH/FSH ratio and lower activity of aromatase and dopaminergic signaling pathways.
khadijeh Haghighat gollo, Fariba Mahmoudi, Abolfazl Bayrami, Saber Zahri   +3 more
doaj  

Decreased risk of breast cancer associated with oral bisphosphonate therapy [PDF]

, 2012
Preclinical studies and adjuvant trials using bisphosphonates have found them to have an antitumor effect. Although major advances have been made in chemoprevention strategies with selective estrogen receptor modulators and aromatase inhibitors, their ...
Brufsky, A, Mathew, A
core   +2 more sources

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

Advanced Healthcare Materials, EarlyView.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti, Cristina Richichi, Daniela Osti, Elena Ceccacci, Giovanni Bertalot, Camilla Cerutti, Giuseppina Giardina, Adriana Marinaro, Brunella Costanza, Valentina Gambino, Elena Zaccheroni, Daniela Tosoni, Maria G. Filippone, Marcello Del Corvo, Yinxiu Zhan, Teresa Gravina, Davide Corà, Monica Patanè, Bianca Pollo, Maria Giovanna Jodice, Salvatore Pece, Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud, Elisabetta Munzone, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci   +27 more
wiley   +1 more source

Preventative therapies for healthy women at high risk of breast cancer [PDF]

, 2014
Licensed under the Creative Commons Attribution Non-Commercial ...
Sestak, I
core   +3 more sources

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor

Molecules, 2020
In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of androgens to estrogens. Aromatase inhibition is an important way to control estrogen-related diseases and estrogen levels.
Ulviye Acar Çevik, Betül Kaya Çavuşoğlu, Begüm Nurpelin Sağlık, Derya Osmaniye, Serkan Levent, Sinem Ilgın, Yusuf Özkay, Zafer Asım Kaplancıklı   +7 more
doaj   +1 more source

A Multiple-Array SPRi Biosensor as a Tool for Detection of Gynecological–Oncological Diseases

Biosensors, 2023
Diagnostics based on the determination of biomarkers in body fluids will be more successful when several biomarkers are determined. A multiple-array SPRi biosensor for the simultaneous determination of CA125, HE4, CEA, IL-6 and aromatase has been ...
Beata Szymanska, Zenon Lukaszewski, Kinga Hermanowicz-Szamatowicz, Ewa Gorodkiewicz   +3 more
doaj   +1 more source

Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis. [PDF]

, 2013
IntroductionEffective treatments for hormone-receptor-positive (HR(+)) breast cancer (BC) following relapse/progression on nonsteroidal aromatase inhibitor (NSAI) therapy are needed. Initial Breast Cancer Trials of OraL EveROlimus-2 (BOLERO-2) trial data
Arena, Francis P, Baselga, José, Burris, Howard A, Cahana, Ayelet, Campone, Mario, Erdkamp, Frans, Feng, Wentao, Gnant, Michael, Harb, Wael A, Hortobagyi, Gabriel N, Lebwohl, David, Melichar, Bohuslav, Noguchi, Shinzaburo, Petrakova, Katarina, Piccart, Martine, Pistilli, Barbara, Pritchard, Kathleen I, Rugo, Hope S, Taran, Tetiana, Yardley, Denise A   +19 more
core   +2 more sources

Editorial Commentary: Estrogen Influences Shoulder Health

Arthroscopy, EarlyView.
Abstract Estrogen influences bone mineral density, muscle quality and quantity, and collagen synthesis, rotator cuff tearing, worse outcomes after rotator cuff repair, hyperlaxity, and adhesive capsulitis. In this commentary, we discuss the potential explanations for the highly significant associations between hormonal systemic birth control and a ...
Peter Chalmers, Robert Tashjian
wiley   +1 more source