Results 51 to 60 of about 47,644 (242)

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Normogonadotropic ovarian insufficiency in adolescence (review of literature and clinical case)

Mìžnarodnij Endokrinologìčnij Žurnal, 2017
The objective of the review. Analysis of literature data related to the normogonadotropic ovarian insufficiency. Basic statements. The article presents a literature review and clinical case of normogonadotropic ovarian insufficiency in girls aged 16 ...
T.V. Sorokman, S.V. Sokolnyk, P.M. Moldovan, N.O. Popeliuk   +3 more
doaj   +1 more source

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity

Molecules, 2023
A novel series of 1,2,3-triazole/1,2,4-triazole hybrids 5a, 5b, and 6a–i was designed and synthesized as antiproliferative agents targeting aromatase enzymes.
Mohamed T-E Maghraby, Tahani Mazyad Almutairi, Stefan Bräse, Ola I. A. Salem, Bahaa G. M. Youssif, Mahmoud M. Sheha   +5 more
doaj   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Non-aromatizable androgens modulate the lipopolysaccharide induced expression of the P2X7 receptor in human adipocytes

Frontiers in Pharmacology, 2023
Introduction: The activation of the P2X7 receptor subtype (P2X7R) has a main role in orchestrating the cellular inflammatory response in many different tissues.
Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Roberto Vettor, Marco Rossato   +4 more
doaj   +1 more source

Rescue of Pressure Overload‐Induced Heart Failure by Estrogen Therapy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Andrea Iorga, Jingyuan Li, Salil Sharma, Soban Umar, Jean C. Bopassa, Rangarajan D. Nadadur, Alexander Centala, Shuxun Ren, Tomoaki Saito, Ligia Toro, Yibin Wang, Enrico Stefani, Mansoureh Eghbali   +12 more
doaj   +1 more source

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

Antibiotics, 2022
Actinobacteria isolated from untapped environments and exposed to extreme conditions such as saltpans are a promising source of novel bioactive compounds.
Omar Messaoudi, Enge Sudarman, Chirag Patel, Mourad Bendahou, Joachim Wink   +4 more
doaj   +1 more source

Aromatase in the Human Brain

Androgens: Clinical Research and Therapeutics, 2021
The aromatase cytochrome P450 (P450arom) enzyme, or estrogen synthase, which is coded by the CYP19A1 gene, is widely expressed in a subpopulation of excitatory and inhibitory neurons, astrocytes, and other cell types in the human brain.
Iñigo Azcoitia, Pablo Mendez, Luis M. Garcia-Segura   +2 more
openaire   +3 more sources

Effects of ethanol or ethylene glycol exposure on PPARγ and aromatase expression in adipose tissue

Biochemistry and Biophysics Reports
The estrogen-synthesizing enzyme aromatase is expressed in adipose tissue where it controls the local concentration of estrogen. It has been suggested that the organic solvents ethanol and ethylene glycol can induce estrogen synthesis by inhibiting PPARγ
Jacob Ardenkjær-Skinnerup, Daniel Saar, Sofie Christiansen, Terje Svingen, Niels Hadrup, Kristy A. Brown, Brice Emanuelli, Birthe B. Kragelund, Gitte Ravn-Haren, Ulla Vogel   +9 more
doaj   +1 more source

Estradiol and the Development of the Cerebral Cortex: An Unexpected Role?

Frontiers in Neuroscience, 2018
The cerebral cortex undergoes rapid folding in an “inside-outside” manner during embryonic development resulting in the establishment of six discrete cortical layers.
Matthew C. S. Denley, Nicholas J. F. Gatford, Katherine J. Sellers, Deepak P. Srivastava, Deepak P. Srivastava   +4 more
doaj   +1 more source