Results 51 to 60 of about 58,906 (283)

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source

Normogonadotropic ovarian insufficiency in adolescence (review of literature and clinical case)

Mìžnarodnij Endokrinologìčnij Žurnal, 2017
The objective of the review. Analysis of literature data related to the normogonadotropic ovarian insufficiency. Basic statements. The article presents a literature review and clinical case of normogonadotropic ovarian insufficiency in girls aged 16 ...
T.V. Sorokman, S.V. Sokolnyk, P.M. Moldovan, N.O. Popeliuk   +3 more
doaj   +1 more source

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity

Molecules, 2023
A novel series of 1,2,3-triazole/1,2,4-triazole hybrids 5a, 5b, and 6a–i was designed and synthesized as antiproliferative agents targeting aromatase enzymes.
Mohamed T-E Maghraby, Tahani Mazyad Almutairi, Stefan Bräse, Ola I. A. Salem, Bahaa G. M. Youssif, Mahmoud M. Sheha   +5 more
doaj   +1 more source

Non-aromatizable androgens modulate the lipopolysaccharide induced expression of the P2X7 receptor in human adipocytes

Frontiers in Pharmacology, 2023
Introduction: The activation of the P2X7 receptor subtype (P2X7R) has a main role in orchestrating the cellular inflammatory response in many different tissues.
Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Roberto Vettor, Marco Rossato   +4 more
doaj   +1 more source

Hypothalamic pituitary gonadal axis (HPG-A) in two men with aromatase deficiency: evidence of estrogen need for the integrity of negative feedback at hypothalamic level [PDF]

, 2006
Estrogen administration to aromatase deficient men discloses a feedback modulation both at pituitary and hypothalamic ...
ZIRILLI, Lucia, Paula Antunez, Antonio R. M. Granata, DIAZZI, Chiara, ROCHIRA, Vincenzo, Antonio Balestrieri, Claudio Aranda, Laura Maffei, CARANI, Cesare, Bibiana Fabre   +9 more
core  

Rescue of Pressure Overload‐Induced Heart Failure by Estrogen Therapy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Andrea Iorga, Jingyuan Li, Salil Sharma, Soban Umar, Jean C. Bopassa, Rangarajan D. Nadadur, Alexander Centala, Shuxun Ren, Tomoaki Saito, Ligia Toro, Yibin Wang, Enrico Stefani, Mansoureh Eghbali   +12 more
doaj   +1 more source

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

Antibiotics, 2022
Actinobacteria isolated from untapped environments and exposed to extreme conditions such as saltpans are a promising source of novel bioactive compounds.
Omar Messaoudi, Enge Sudarman, Chirag Patel, Mourad Bendahou, Joachim Wink   +4 more
doaj   +1 more source

Brain Aromatase in the guppy, Poecilia reticulata [Elektronisk resurs] : Distribution, control and role in behaviour [PDF]

, 2009
Oestrogens are produced by aromatisation of androgens by the aromatase enzyme. In the vertebrate brain this synthesis has vital functions in nerve protection, cell proliferation and nerve development during injury respectively brain development.
Olsén, Håkan,, Borg, Bertil,, Hallgren, Stefan,, Bakker, Julie,   +3 more
core  

Aromatase Gene Expression and Regulation in the Female Rat Pituitary [PDF]

, 2006
International audienceAromatase cytochrome P450, the key enzyme of estrogen biosynthesis from androgens, is encoded by CYP19. Its structure shows some peculiarities: exons II to X encode the protein, while multiple alternative exons I encode unique 5 ...
Corvaisier, Sophie, GUILLAUME GALMICHE, Kottler, Marie-Laure, MARIE‐LAURE KOTTLER, SOPHIE CORVAISIER, Galmiche, Guillaume   +5 more
core   +1 more source

Editorial Commentary: Estrogen Influences Shoulder Health

Arthroscopy, EarlyView.
Abstract Estrogen influences bone mineral density, muscle quality and quantity, and collagen synthesis, rotator cuff tearing, worse outcomes after rotator cuff repair, hyperlaxity, and adhesive capsulitis. In this commentary, we discuss the potential explanations for the highly significant associations between hormonal systemic birth control and a ...
Peter Chalmers, Robert Tashjian
wiley   +1 more source