Results 21 to 30 of about 11,431 (185)
Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity
Frontiers in Oncology, 2019 Membrane heparan sulfate proteoglycans (HSPG) regulate cell proliferation, migration, and differentiation and are therefore considered key players in cancer cell development processes.
Jlenia Brunetti +9 more
doaj +1 more source
Sulfatases: Critical Enzymes for Algal Polysaccharide Processing
Frontiers in Plant Science, 2022 Microbial sulfatases are important biocatalysts in the marine environment where they play a key role in the catabolic biotransformation of abundant sulphated algal polysaccharides. The sulphate esters decorating algal polysaccharides, such as carrageenan,
Andrew G. Hettle +2 more
doaj +1 more source
Molecular Cancer, 2005 Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with heparin-binding growth factor signaling.
Giese Nathalia A +8 more
doaj +1 more source
Sulfatase 1 and sulfatase 2 as novel regulators of macrophage antigen presentation and phagocytosis [PDF]
Yeungnam University Journal of Medicine, 2021 Background Sulfation of heparan sulfate proteoglycans (HSPGs) is critical for the binding and signaling of ligands that mediate inflammation. Extracellular 6-O-endosulfatases regulate posttranslational sulfation levels and patterns of HSPGs.
Hyun-Je Kim +2 more
doaj +1 more source
Post-synthetic regulation of HS structure: the yin and yang of the Sulfs in Cancer
Frontiers in Oncology, 2014 Heparan sulfate (HS) is a complex polysaccharide that takes part in most major cellular processes, through its ability to bind and modulate a very large array of proteins.
Romain R Vives +2 more
doaj +1 more source
Agronomy, 2022 The plant–pest interaction and its mechanisms are a novel research direction for pest control. They provide molecular targets for developing new pesticides and targeted control measures to control insect herbivores.
Xue Li +7 more
doaj +1 more source
The important roles of steroid sulfatase and sulfotransferases in gynecological diseases
Frontiers in Pharmacology, 2016 Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women.
Tea eLanisnik Rizner
doaj +1 more source
The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers
Frontiers in Pharmacology, 2017 Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in ...
Tea Lanišnik Rižner +2 more
doaj +1 more source
Frontiers in Plant Science, 2021 Cruciferous plants in the order Brassicales defend themselves from herbivory using glucosinolates: sulfur-containing pro-toxic metabolites that are activated by hydrolysis to form compounds, such as isothiocyanates, which are toxic to insects and other ...
Abinaya Manivannan +11 more
doaj +1 more source
SUMF1 enhances sulfatase activitiesin vivoin five sulfatase deficiencies [PDF]
Biochemical Journal, 2007 Sulfatases are enzymes that hydrolyse a diverse range of sulfate esters. Deficiency of lysosomal sulfatases leads to human diseases characterized by the accumulation of either GAGs (glycosaminoglycans) or sulfolipids. The catalytic activity of sulfatases resides in a unique formylglycine residue in their active site generated by the post-translational ...
FRALDI, ALESSANDRO +10 more
openaire +4 more sources