Results 41 to 50 of about 22,801 (226)
The important roles of steroid sulfatase and sulfotransferases in gynecological diseases
Frontiers in Pharmacology, 2016 Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women.
Tea eLanisnik Rizner
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Enzyme replacement therapies: What is the best option? [PDF]
, 2018 Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the ...
Barar, Jaleh +4 more
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The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers
Frontiers in Pharmacology, 2017 Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in ...
Tea Lanišnik Rižner +2 more
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Frontiers in Plant Science, 2021 Cruciferous plants in the order Brassicales defend themselves from herbivory using glucosinolates: sulfur-containing pro-toxic metabolites that are activated by hydrolysis to form compounds, such as isothiocyanates, which are toxic to insects and other ...
Abinaya Manivannan +11 more
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Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship [PDF]
Human Molecular Genetics, 2005 Sulfatases catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates. Several human inherited diseases are caused by the deficiency of individual sulfatases, while in patients with multiple sulfatase deficiency mutations in the Sulfatase Modifying Factor 1 (SUMF1) gene cause a defect in the post-translational modification of a ...
SARDIELLO M. +3 more
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SUMF1 enhances sulfatase activitiesin vivoin five sulfatase deficiencies [PDF]
Biochemical Journal, 2007 Sulfatases are enzymes that hydrolyse a diverse range of sulfate esters. Deficiency of lysosomal sulfatases leads to human diseases characterized by the accumulation of either GAGs (glycosaminoglycans) or sulfolipids. The catalytic activity of sulfatases resides in a unique formylglycine residue in their active site generated by the post-translational ...
FRALDI, ALESSANDRO +10 more
openaire +4 more sources
EMBO Molecular Medicine, 2023 Multiple sulfatase deficiency (MSD, MIM #272200) results from pathogenic variants in the SUMF1 gene that impair proper function of the formylglycine‐generating enzyme (FGE).
Lars Schlotawa +20 more
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A Simple Method for On-Gel Detection of Myrosinase Activity
Molecules, 2018 Myrosinase is an enzyme present in many functional foods and spices, particularly in Cruciferous vegetables. It hydrolyses glucosinolates which thereafter rearrange into bioactive volatile constituents (isothiocyanates, nitriles).
Sándor Gonda +6 more
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Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. [PDF]
PLoS ONE, 2013 The genome of Mycobacterium tuberculosis (Mtb) encodes nine putative sulfatases, none of which have a known function or substrate. Here, we characterize Mtb's single putative type II sulfatase, Rv3406, as a non-heme iron (II) and α-ketoglutarate ...
Kimberly M Sogi +5 more
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Comparative Study of Two Chondroitin Sulfate/Dermatan Sulfate 4-O-Sulfatases With High Identity
Frontiers in Microbiology, 2019 Chondroitin sulfate/dermatan sulfate (CS/DS) sulfatases are potential tools for structural and functional studies of CD/DS chains. In our previous study, a CS/DS 4-O-endosulfatase (endoVB4SF) was identified from a marine bacterium (Wang et al., 2015 ...
Shumin Wang +6 more
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