Results 41 to 50 of about 11,431 (185)

Sulfatase Assay to Determine Influence of Plants on Microbial Activity in Soil

Bio-Protocol, 2020
Sulfatase activity is often used as a measure of the activity of soil microorganisms. It is thus a suitable tool to investigate the response of microbes to plants.
Anna Koprivova, Achim Schmalenberger, Stanislav Kopriva   +2 more
doaj   +1 more source

Alkyl Sulfatase of Cholera Vibrios

Проблемы особо опасных инфекций, 2023
The aim of the work was to study the structure of the alkyl sulfatase (asu) gene in Vibrio cholerae strains of various serogroups, as well as to compare nucleotide and amino acid sequences of alkyl sulfatases using various methods of bioinformatic ...
O. V. Duvanova, O. A. Podoinitsyna, R. V. Pisanov, S. O. Vodop’yanov, A. S. Vodop’yanov, E. S. Shipko, V. D. Kruglikov, O. S. Chemisova, A. K. Noskov   +8 more
doaj   +1 more source

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer

Frontiers in Pharmacology, 2017
Endometrial cancer (EC) is the most common estrogen-dependent gynecological malignancy in the developed World. To investigate the local formation of estradiol (E2), we first measured the concentrations of the steroid precursor androstenedione (A-dione ...
Maša Sinreih, Tamara Knific, Maja Anko, Neli Hevir, Katja Vouk, Aleš Jerin, Snježana Frković Grazio, Tea Lanišnik Rižner   +7 more
doaj   +1 more source

A clinical case of physical therapy of a child with multiple sulfatase deficiency

Medičnì Perspektivi, 2021
The article deals with the problems of physical therapy in children with multiple sulfatase deficiency (MSD). The purpose of the study presented in the article was to substantiate the need to form a structured, personalized comprehensive rehabilitation ...
I.M. Grygus , O.B. Nagorna , N.E. Nesterchuk , A.O. Nogas , P.S. Podoliaka , T.V. Gamma   +5 more
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Determination of desulpho-glucosinolates in bolting stems of Chinese kale by liquid chromatography-mass spectrometry

浙江大学学报. 农业与生命科学版, 2008
The crude glucosinolates (GSs) were extracted from bolting stems of Chinese kale (Brassica alboglabra) and purified by a column packed with DEAE Sephadex A-25. The desulpho-glucosinolates were obtained after desulfurizing of GSs by sulfatase.
LA Gui-xiao, FANG Ping, LI Ya-juan, WANG Yue   +3 more
doaj   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Trauma promotes heparan sulfate modifications and cleavage that disrupt homeostatic gene expression in microvascular endothelial cells

Frontiers in Cell and Developmental Biology
Introduction: Heparan sulfate (HS) in the vascular endothelial glycocalyx (eGC) is a critical regulator of blood vessel homeostasis. Trauma results in HS shedding from the eGC, but the impact of trauma on HS structural modifications that could influence ...
Robert P. Richter, Robert P. Richter, James D. Odum, Camilla Margaroli, Jessica C. Cardenas, Lei Zheng, Kaushlendra Tripathi, Zhangjie Wang, Katelyn Arnold, Ralph D. Sanderson, Jian Liu, Jillian R. Richter, Jillian R. Richter   +12 more
doaj   +1 more source