Results 61 to 70 of about 15,873 (215)

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen, Amnah Omar Mahajna, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Trauma promotes heparan sulfate modifications and cleavage that disrupt homeostatic gene expression in microvascular endothelial cells

Frontiers in Cell and Developmental Biology
Introduction: Heparan sulfate (HS) in the vascular endothelial glycocalyx (eGC) is a critical regulator of blood vessel homeostasis. Trauma results in HS shedding from the eGC, but the impact of trauma on HS structural modifications that could influence ...
Robert P. Richter, Robert P. Richter, James D. Odum, Camilla Margaroli, Jessica C. Cardenas, Lei Zheng, Kaushlendra Tripathi, Zhangjie Wang, Katelyn Arnold, Ralph D. Sanderson, Jian Liu, Jillian R. Richter, Jillian R. Richter   +12 more
doaj   +1 more source

The Burden of Airway Disease in Mucopolysaccharidoses: Evidence Across Subtypes

The Laryngoscope, EarlyView.
ABSTRACT Objective To synthesize the prevalence and subtype‐specific patterns of airway manifestations in mucopolysaccharidoses (MPS) and summarize related morbidity and mortality. Data Sources PubMed, CINAHL, Ovid Embase, Ovid MEDLINE, and Ovid All EBM Reviews.
Julia Edward, Alix Pincivy, Mathieu Bergeron   +2 more
wiley   +1 more source

Exposure to Common Food Additive Carrageenan Leads to Reduced Sulfatase Activity and Increase in Sulfated Glycosaminoglycans in Human Epithelial Cells [PDF]

, 2012
The commonly used food additive carrageenan, including lambda (λ), kappa (κ) and iota (ι) forms, is composed of galactose disaccharides linked in alpha-1,3 and beta-1,4 glycosidic bonds with up to three sulfate groups per disaccharide residue ...
Sumit Bhattacharyya (14205), Robert Linhardt (3590762), Joanne Tobacman (7924235), Bo Yang (104813)   +3 more
core   +3 more sources

Anaerobic Degradation of Sulfated Polysaccharides by Two Novel Kiritimatiellales Strains Isolated From Black Sea Sediment

Frontiers in Microbiology, 2019
The marine environment contains a large diversity of sulfated polysaccharides and other glycopolymers. Saccharolytic microorganisms degrade these compounds through hydrolysis, which includes the hydrolysis of sulfate groups from sugars by sulfatases ...
Daan M. van Vliet, Susakul Palakawong Na Ayudthaya, Susakul Palakawong Na Ayudthaya, Sally Diop, Laura Villanueva, Alfons J. M. Stams, Alfons J. M. Stams, Irene Sánchez-Andrea   +7 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder, driven by multiple mechanisms among which are lysosomal and mitochondrial dysfunction. Here, we explored blood‐based lysosomal and mitochondrial profiles in relation to PD diagnosis and severity.
Janna van Wetering, Manon M. van Ingen, Evelien Timmermans, Sjors G.J.G. in't Veld, Henk W. Berendse, Charlotte E. Teunissen, Wilma D.J. van de Berg   +6 more
wiley   +1 more source

Sulfatase-Induced In Situ Formulation of Antineoplastic Supra-PROTACs

Proteolysis targeting chimera (PROTAC) technology is an innovative strategy for cancer therapy, which, however, suffers from poor targeting delivery and limited capability for protein of interest (POI) degradation.
Binbin Hu (5450897), Zeyu Zhang (549929), Ruo-Chen Guo (18150825), Ninglin Chen (17676525), Peng Zhang (2071), Yang Shi (175282), Hongbo Wang (587749), Xin Liu (43569), Zhilin Yu (3130656), Hao Wang (39217), Zhonghua Liu (148625)   +10 more
core   +1 more source

Coreopsis tinctoria Nutt. Polyphenols Ameliorate CUMS‐Induced Depressive Behaviors and Hippocampal Neuronal Damage in Mice [PDF]

Food Sci Nutr
The capitula of Coreopsis tinctoria Nutt. polyphenol extract (CCTE) attenuate CUMS‐induced depressive‐like behaviors and hippocampal neuronal damage in mice. Three flavonoid aglycones—okanin, isookanin, and taxifolin—cross the blood–brain barrier and synergistically inhibit MAO‐A, restoring serotonergic tone; concurrently, CCTE normalizes HPA‐axis ...
Han H, Feng Y, Wang Z, Ma R, Sun J, Yang X, Cui Y, Wang J, Jia M.   +8 more
europepmc   +2 more sources

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source