Results 81 to 90 of about 15,873 (215)
Detection of bacterial sulfatase activity through liquid- and solid-phase colony-based assays
Bacterial arylsulfatases are crucial to biosynthesis in many microorganisms, as bacteria often utilize aryl sulfates as a source of sulfur. The bacterial sulfatases are associated with pathogenesis and are applied in many areas such as industry and ...
Hey Young Yoon +3 more
doaj +1 more source
ABSTRACT The interplay between diet, gut microbiota, and host immunity is central to food science. The Lachnospiraceae family ferments dietary fibers to produce short‐chain fatty acids (SCFAs), notably butyrate and propionate, with immunomodulatory potential. This critical review distinguishes established findings from hypotheses.
Ruijun Wang +4 more
wiley +1 more source
Enrichable consortia of microbial symbionts degrade macroalgal polysaccharides in Kyphosus fish
Coastal herbivorous fishes consume macroalgae, which is then degraded by microbes along their digestive tract. However, there is scarce genomic information about the microbiota that perform this degradation.
Aaron Oliver +10 more
doaj +1 more source
Therapy of sulfatase deficiencies
The present invention related to improved gene therapy to treat sulfatase deficiencies, preferably via co-delivery of Sulfatase enzymes and SUMF1 ...
SORRENTINO NC, FRALDI A, Ballabio A
core
Biochemical signatures of disease severity in Multiple Sulfatase Deficiency
Sulfatases catalyze essential cellular reactions, including degradation of glycosaminoglycans (GAGs). All sulfatases are post‐translationally activated by the formylglycine generating enzyme (FGE) which is deficient in Multiple Sulfatase Deficiency (MSD),
Schlotawa, Lars +10 more
core +1 more source
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
A Simple Staining Method for Increasing Sensitivity in Detection of Alkyl Sulfatase in Native Polyacrylamide Gels [PDF]
SUMMARYTo increase the sensitivity in detection of alkyl sulfatases in Native PAGE gels, we report here a simple staining method based on Coomassie brillent blue R 250.
Ashok Kumar, Venkatesh Chaturvedi*,
core
Researches on Sulfatase Models, IV
unsym.メチルフェニルヒドラヂンはヒドラヂン以上にグルコーゼ硫酸の分解を促進するが, Sym.アセチルフェニルヒドラヂンは全くその作用がない.從つてグルコスルフ,ターゼ模型としての作用を有する爲にはヒドラヂンの少くとも1個のアミノ基は遊離して居なければならないと思はれる.グルコスルファターゼ模型としてのヒドラヂンの特異性は必ずしもグルコスルファターゼの特異性と現在見做されて居るもの2)とは一致しない.即ち,バウシウボラより得られたグルコスルファターゼ製品はα-メチルグルコシド硫酸,蔗糖硫酸等をも分解するが,ヒドラヂンは,ヒドラヂン誘導體縮合生成物を作る様な還元糖等の硫酸エステルに限り分解する.
openaire +6 more sources
Flavonoid consumption may modulate phospholipase activity and COX‐, LOX‐, and CYP450‐dependent oxylipin biosynthesis, reshaping lipid mediator networks. Emerging evidence suggests these shifts may favor inflammatory resolution over propagation, with implications for metabolic, cardiovascular, and neuroinflammatory disease risk.
Joseph Arballo, Mary Ann Lila
wiley +1 more source

