Results 71 to 80 of about 11,431 (185)

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, Volume 293, Issue 14, Page 4206-4231, July 2026.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Prenatal Bisphenol A Exposure and Sex‐Differentiated Childhood BMI Over Time: A Longitudinal Korean Cohort Study

Pediatric Obesity, Volume 21, Issue 7, July 2026.
ABSTRACT Background Prenatal exposure to bisphenol A (BPA), an endocrine‐disrupting chemical, may influence childhood obesity. Evidence on sex‐specific effects remains inconsistent. Methods We analysed 528 mother–child pairs from a Korean birth cohort. Maternal urinary BPA concentrations were measured during mid‐pregnancy.
Youn‐Hee Lim, Yun‐Chul Hong, Yun Jeong Lee, Choong Ho Shin, Dongwook Lee, Bung‐Nyun Kim, Johanna Inhyang Kim, Young Ah Lee   +7 more
wiley   +1 more source

A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency

Cell, 1995
Multiple sulfatase deficiency (MSD) is a lysosomal storage disorder characterized by a decreased activity of all known sulfatases. The deficiency of sulfatases was proposed to result from the lack of a co- or posttranslational modification that is common to all sulfatases and required for their catalytic activity.
Schmidt, Bernhard, Selmer, Thorsten, Ingendoh, Arnd, Figura, Kurt von   +3 more
openaire   +4 more sources

Sulfate starvation response modules connect sulfur metabolism to photorespiration and photosynthesis

The Plant Journal, Volume 127, Issue 1, July 2026.
Significance Statement How plants regulate mineral homeostasis and integrate it with other physiological processes is crucial for developing crops that can better withstand environmental challenges. In this study, we show that PYD4 (PYRIMIDINE 4) and MGL (METHIONINE GAMMA‐LYASE), are involved in sulfate starvation response regulation. Moreover, PYD4 is
Suvajit Basu, Inken Thiemann, Stefan Timm, Varsa Shukla, Philipp Baessler, Philipp Westhoff, Stanislav Kopriva, Daniela Ristova   +7 more
wiley   +1 more source

Recognition and ER Quality Control of Misfolded Formylglycine-Generating Enzyme by Protein Disulfide Isomerase

Cell Reports, 2018
Summary: Multiple sulfatase deficiency (MSD) is a fatal, inherited lysosomal storage disorder characterized by reduced activities of all sulfatases in patients.
Lars Schlotawa, Michaela Wachs, Olaf Bernhard, Franz J. Mayer, Thomas Dierks, Bernhard Schmidt, Karthikeyan Radhakrishnan   +6 more
doaj   +1 more source

Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Ring A halogenated 13α-, 13β-, and 17-deoxy-13α-estrone derivatives were synthesised with N-halosuccinimides as electrophile triggers. Substitutions occurred at positions C-2 and/or C-4.
Ildikó Bacsa, Bianka Edina Herman, Rebeka Jójárt, Kevin Stefán Herman, János Wölfling, Gyula Schneider, Mónika Varga, Csaba Tömböly, Tea Lanišnik Rižner, Mihály Szécsi, Erzsébet Mernyák   +10 more
doaj   +1 more source

Neonatal multiple sulfatase deficiency with a novel mutation and review of the literature

The Turkish Journal of Pediatrics, 2014
Multiple sulfatase deficiency is a rare autosomal recessive disorder in which affected individuals present a complex phenotype due to the impaired activity of all sulfatases.
Banu Güzel Nur, Ercan Mıhçı, Stefano Pepe, Gürsel Biberoğlu, Fatih Süheyl Ezgü, Andrea Ballabio, Osman Öztekin, Oğuz Dursun   +7 more
doaj  

Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model

Communications Medicine
Background Multiple Sulfatase Deficiency (MSD) is an ultra-rare autosomal recessive disorder characterized by deficient enzymatic activity of all known sulfatases. MSD patients frequently carry two loss of function mutations in the SUMF1 gene, encoding a
Maximiliano Presa, Vi Pham, Somdatta Ray, Pierre-Alexandre Piec, Jennifer Ryan, Timothy Billings, Harold Coombs, Lars Schlotawa, Troy Lund, Rebecca C. Ahrens-Nicklas, Cathleen Lutz   +10 more
doaj   +1 more source

Isolation of a strain of Pseudomonas putida capable of metabolizing anionic detergent sodium dodecyl sulfate (SDS)

Iranian Journal of Microbiology, 2011
Background and objectives: Sodium Dodecyl Sulfate (SDS) is one of the most widely used anionic detergents. The present study deals with isolation and identification of SDS-degrading bacteria from a detergent contaminated pond situated in Varanasi city ...
V Chaturvedi, A Kumar
doaj