Dehydroepiandrosterone sulfate mediates activation of transcription factors CREB and ATF-1 via a Gα11-coupled receptor in the spermatogenic cell line GC-2 [PDF]
Dehydroepiandrosterone sulfate (DHEAS) is a circulating steroid produced in the adrenal cortex, brain, and gonads. Whereas a series of investigations attest to neuroprotective effects of the steroid in the brain, surprisingly little is known about the ...
Adam, Jaroslav +50 more
core +2 more sources
Detection of bacterial sulfatase activity through liquid- and solid-phase colony-based assays
Bacterial arylsulfatases are crucial to biosynthesis in many microorganisms, as bacteria often utilize aryl sulfates as a source of sulfur. The bacterial sulfatases are associated with pathogenesis and are applied in many areas such as industry and ...
Hey Young Yoon +3 more
doaj +1 more source
Teriparatide in Two Patients With Mucopolysaccharidosis Type IVB
ABSTRACT Mucopolysaccharidosis Type IV is a multisystem lysosomal storage disease characterized by severe skeletal dysplasia resulting from impaired degradation of the glycosaminoglycans keratan sulfate and chondroitin‐6‐sulfate. The condition is classified into Types A and B based on the underlying enzyme deficiency.
Mark Wijnen +5 more
wiley +1 more source
Identification and characterization of a glycosulfatase-encoding gene cluster in Bifidobacterium breve UCC2003 [PDF]
Bifidobacteria constitute a specific group of commensal bacteria, typically found in the gastrointestinal tract (GIT) of humans and other mammals. Bifidobacterium breve strains are numerically prevalent among the gut microbiota of many healthy breast-fed
Egan, Muireann +4 more
core +1 more source
Sample Preparation and Separation of Lignans by Liquid Chromatography
ABSTRACT Lignans are important phytochemicals found mostly in the resins of coniferous trees, but are also introduced into human diets through foods such as sesame seeds and extra‐virgin olive oil. They are pharmacologically interesting mainly because of their antioxidant activities, and they have also been shown to have cytotoxic and antimicrobial ...
Miikka Paloluoto, Susanne K. Wiedmer
wiley +1 more source
Enrichable consortia of microbial symbionts degrade macroalgal polysaccharides in Kyphosus fish
Coastal herbivorous fishes consume macroalgae, which is then degraded by microbes along their digestive tract. However, there is scarce genomic information about the microbiota that perform this degradation.
Aaron Oliver +10 more
doaj +1 more source
IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients [PDF]
Purpose: Irosustat is a first-generation, orally active, irreversible steroid sulfatase inhibitor. We performed a multicentre, open label phase II trial of the addition of Irosustat to a first-line aromatase inhibitor (AI) in patients with advanced BC to
A Billich +49 more
core +2 more sources
Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers +16 more
wiley +1 more source
Multiple sulfatase deficiency: A case series of four children
Multiple sulfatase deficiency is biochemically characterized by the accumulation of sulfated lipids and acid mucopolysaccharides. The gene sulfatase-modifying factor 1 (SUMF1), recently identified, encodes the enzyme responsible for post-translational ...
Faruk Incecik +7 more
doaj +1 more source
CO 2 Fluxes and Soil Responses to Straw and Herbicide in Peanut
ABSTRACT Peanut cultivation plays an important agronomic role in Brazil, especially in rotation with sugarcane, promoting biological nitrogen fixation and improving soil quality. This study aimed to test the hypothesis that the combined use of sugarcane mulch, peanut cultivation, and herbicide application would affect soil CO₂ fluxes, soil chemical ...
Heytor Lemos Martins +7 more
wiley +1 more source

