Results 31 to 40 of about 50,719 (280)
G3: Genes, Genomes, Genetics, 2020 Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair.
Claire Reynolds-Peterson +11 more
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Frontiers in Physiology, 2018 The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular ...
M. F. Galvis-Ramírez +2 more
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Bioengineered heparins and heparan sulfates [PDF]
Advanced Drug Delivery Reviews, 2016 Heparin and heparan sulfates are closely related linear anionic polysaccharides, called glycosaminoglycans, which exhibit a number of important biological and pharmacological activities. These polysaccharides, having complex structures and polydispersity, are biosynthesized in the Golgi of animal cells.
Li, Fu +2 more
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EXT proteins: Role in heparan sulfate Assembly and in Tumor biology [PDF]
, 2018 The exostosin family of proteins is necessary for heparan sulfate biosynthesis. Heparan sulfate polysaccharide biosynthesis is one of several different forms of proteinglycosylation processes that take place in the Golgi apparatus.
Sembajwe, Lawrence Fred
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Molecules, 2017 Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine.
Ha Na Kim +2 more
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Chemistry and biology of heparin and heparan sulfate /
, 2005 The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan
Garg, Hari G. +2 more
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Heparin and Heparan Sulfate Biosynthesis [PDF]
IUBMB Life, 2002 AbstractHeparan sulfate is one of the most informationally rich biopolymers in Nature. Its simple sugar backbone is variously modified to different degrees depending on the cellular conditions. Thus, it matures to have an enormously complicated structure, which most likely exhibits a considerable number of unique overlapping sequences with peculiar ...
Kazuyuki, Sugahara, Hiroshi, Kitagawa
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Structural Analysis of Heparan Sulfate and Heparan Sulfate Oligosaccharides.
Trends in Glycoscience and Glycotechnology, 1998 ヘパラン硫酸は構造的に複雑な生体内高分子で、様々な重要な生物活性発現に関わる可能性が認められ、最近活発に研究されるようになった。ヘパラン硫酸の生物活性発現はグリコサミノグリカン糖鎖による。このグリコサミノグリカンは、複雑な構造多様性を示す二糖単位から構成され、その糖鎖長も一定でない。この複雑な糖鎖を構造決定しようとする試みは、あらゆる方法を用いて遂行されたにもかかわらず、未だ達成されていない。最近のヘパラン硫酸糖鎖構造に関する研究は、もっぱらある種の生物活性を示す最小糖鎖配列を高分子部分から切り出し、その構造を同定することに焦点が絞られている。このミニレビューでは、ヘパラン硫酸由来のオリゴ糖鎖の調製、単離および構造決定法について最近の文献を挙げ、総説する。特に、高速液体クロマトグラフィー ...
Toida, Toshihiko, Linhardt, R. J.
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Heparan sulfate proteoglycans at a glance [PDF]
Journal of Cell Science, 2007 Proteoglycans are abundant components of the cell surface and extracellular matrix that mediate critical interactions between cells and their environment. They play a variety of biological roles in normal tissues and in response to injury and disease.
Catherine A, Kirkpatrick +1 more
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Bio-Protocol, 2017 Heparan sulfate (HS) is purified from complex matrices and often not fully characterised to validate its assignment. The characterisation of heparins and heparan sulfates through enzymatic depolymerisation and subsequent strong anion-exchange high ...
Susan Carnachan, Simon F.R. Hinkley
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