Results 21 to 30 of about 41,050 (163)
Graft glycocalyx degradation in human liver transplantation.
PLoS ONE, 2019 ObjectiveIschaemia/reperfusion-injury degrades endothelial glycocalyx. Graft glycocalyx degradation was studied in human liver transplantation.MethodsTo assess changes within the graft, blood was drawn from portal and hepatic veins in addition to ...
Arie Passov +6 more
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G3: Genes, Genomes, Genetics, 2020 Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair.
Claire Reynolds-Peterson +11 more
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Heparan sulfate signaling in cancer [PDF]
Trends in Biochemical Sciences, 2014 Heparan sulfate (HS) is a biopolymer consisting of variably sulfated repeating disaccharide units. The anticoagulant heparin is a highly sulfated intracellular variant of HS. HS has demonstrated roles in embryonic development, homeostasis, and human disease via non-covalent interactions with numerous cellular proteins, including growth factors and ...
Erik H, Knelson +2 more
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Frontiers in Physiology, 2018 The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular ...
M. F. Galvis-Ramírez +2 more
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Molecules, 2017 Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine.
Ha Na Kim +2 more
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Bio-Protocol, 2017 Heparan sulfate (HS) is purified from complex matrices and often not fully characterised to validate its assignment. The characterisation of heparins and heparan sulfates through enzymatic depolymerisation and subsequent strong anion-exchange high ...
Susan Carnachan, Simon F.R. Hinkley
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Bioengineered heparins and heparan sulfates [PDF]
Advanced Drug Delivery Reviews, 2016 Heparin and heparan sulfates are closely related linear anionic polysaccharides, called glycosaminoglycans, which exhibit a number of important biological and pharmacological activities. These polysaccharides, having complex structures and polydispersity, are biosynthesized in the Golgi of animal cells.
Li, Fu +2 more
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Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis
BloodAbstract From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology.
Richard T. Piszczatowski +2 more
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Structural Analysis of Heparan Sulfate and Heparan Sulfate Oligosaccharides.
Trends in Glycoscience and Glycotechnology, 1998 ヘパラン硫酸は構造的に複雑な生体内高分子で、様々な重要な生物活性発現に関わる可能性が認められ、最近活発に研究されるようになった。ヘパラン硫酸の生物活性発現はグリコサミノグリカン糖鎖による。このグリコサミノグリカンは、複雑な構造多様性を示す二糖単位から構成され、その糖鎖長も一定でない。この複雑な糖鎖を構造決定しようとする試みは、あらゆる方法を用いて遂行されたにもかかわらず、未だ達成されていない。最近のヘパラン硫酸糖鎖構造に関する研究は、もっぱらある種の生物活性を示す最小糖鎖配列を高分子部分から切り出し、その構造を同定することに焦点が絞られている。このミニレビューでは、ヘパラン硫酸由来のオリゴ糖鎖の調製、単離および構造決定法について最近の文献を挙げ、総説する。特に、高速液体クロマトグラフィー ...
Toida, Toshihiko, Linhardt, R. J.
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Brazilian Journal of Medical and Biological Research, 2001 The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed.
H.B. Nader +12 more
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