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Heparan sulfate proteoglycans: structure, protein interactions and cell signaling [PDF]

Anais da Academia Brasileira de Ciências, 2009
Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species. This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions ...
Juliana L. Dreyfuss, Caio V. Regatieri, Thais R. Jarrouge, Renan P. Cavalheiro, Lucia O. Sampaio, Helena B. Nader   +5 more
doaj   +2 more sources

Expression Pattern of Sulf1 and Sulf2 in Chicken Tissues and Characterization of Their Expression During Different Periods in Skeletal Muscle Satellite Cells [PDF]

Brazilian Journal of Poultry Science
Heparan sulfate proteoglycans (HSPGs) are present on the cell surface and in the extracellular matrix in all metazoans. HSPGs interact with growth factors and receptors through heparan sulfate (HS) chains.
L He, H Xu, F Ye, H Yu, Y Lu, H Yin, X Zhao, Q Zhu, Y Wang   +8 more
doaj   +2 more sources

Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. [PDF]

PLoS ONE, 2010
Lipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulation, liberating free fatty acids for energy metabolism or storage.
Joseph R Bishop, Maria Rita Passos-Bueno, Loren Fong, Kristin I Stanford, Jon C Gonzales, Erika Yeh, Stephen G Young, Andre Bensadoun, Joseph L Witztum, Jeffrey D Esko, Karen S Moulton   +10 more
doaj   +1 more source

Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys

Cardiovascular Diabetology, 2004
Background Arterial proteoglycans are implicated in the pathogenesis of atherosclerosis by their ability to trap plasma lipoproteins in the arterial wall and by their influence on cellular migration, adhesion and proliferation.
Litwak Kenneth N, Vogl-Willis Catherine A, Wagner Janice D, Edwards Iris J, Cefalu William T   +4 more
doaj   +1 more source

Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis

Frontiers in Genetics, 2021
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan sulfate are covalently attached to specific core proteins to form proteoglycans, which are distributed at the cell surface as well as in the extracellular matrix ...
Shuji Mizumoto, Shuhei Yamada
doaj   +1 more source

Effect of epithelial debridement on human cornea proteoglycans

Brazilian Journal of Medical and Biological Research, 2001
Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano, M.S.Q. Campos, J.A.K. Aguiar, Y.M. Michelacci   +3 more
doaj   +1 more source

Syndecan 4 Upregulation on Activated Langerhans Cells Counteracts Langerin Restriction to Facilitate Hepatitis C Virus Transmission

Frontiers in Immunology, 2020
Sexually transmitted Hepatitis C virus (HCV) infections and high reinfections are a major concern amongst men who have sex with men (MSM) living with HIV-1 and HIV-negative MSM.
Bernadien M. Nijmeijer, Julia Eder, Catharina J. M. Langedijk, Tanja M. Kaptein, Sofie Meeussen, Pascale Zimmermann, Pascale Zimmermann, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek   +8 more
doaj   +1 more source

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

Scientific Reports, 2017
Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse, Hodaka Yamakado, Xander M. van Wijk, Roger Lawrence, Jeffrey D. Esko, Eliezer Masliah   +5 more
doaj   +1 more source

Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth

Neoplasia: An International Journal for Oncology Research, 2016
In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However, little is known regarding the genetic and functional importance of glycan chains displayed by ...
Roland El Ghazal, Xin Yin, Scott C. Johns, Lee Swanson, Monica Macal, Pradipta Ghosh, Elina I. Zuniga, Mark M. Fuster   +7 more
doaj   +1 more source

Heparan Sulfate Proteoglycan Signaling in Tumor Microenvironment [PDF]

International Journal of Molecular Sciences, 2020
In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an intriguing subject of study for their complex structural characteristics, their finely regulated biosynthetic machinery, and the wide range of functions they perform in living organisms from development to adulthood.
De Pasquale, Valeria, Pavone, Luigi Michele   +1 more
openaire   +3 more sources