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Heparan Sulfate Proteoglycans in Tauopathy [PDF]
Biomolecules, 2022 Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu +7 more
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Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression [PDF]
Frontiers in Endocrinology, 2018 Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate
Arvindhan Nagarajan +2 more
exaly +5 more sources
Heparan Sulfate Proteoglycans as Relays of Neuroinflammation [PDF]
Journal of Histochemistry and Cytochemistry, 2018 Heparan sulfate proteoglycans (HSPGs) are implicated as inflammatory mediators in a variety of settings, including chemokine activation, which is required to recruit circulating leukocytes to infection sites. Heparan sulfate (HS) polysaccharide chains are highly interactive and serve co-receptor roles in multiple ligand:receptor interactions.
Paul O’Callaghan, Jin-Ping Li
exaly +5 more sources
A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors [PDF]
Frontiers in Immunology, 2021 While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell receptors with non-conventional ligands, particularly carbohydrate antigens, is less well ...
Klara Klein +16 more
doaj +2 more sources
Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis.
BloodAbstract From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology.
Piszczatowski RT, Bülow HE, Steidl U.
europepmc +3 more sources
Heparan sulfate proteoglycans in glomerular inflammation [PDF]
Kidney International, 2004 Heparan sulfate proteoglycans (HSPGs) are glycoproteins consisting of a core protein to which linear heparan sulfate side chains are covalently attached. These heparan sulfate side chains can be modified at different positions by several enzymes, which include N-deacetylases, N- and O-sulfotransferases, and an epimerase.
Angelique L W M M Rops +2 more
exaly +4 more sources
Profiling Heparan Sulfate Proteoglycans in Ovarian Carcinoma [PDF]
The Scientific World Journal, 2005 : heparan sulfate, proteoglycans, syndecan, glypican, perlecan, ovarian carcinoma, angiogenesis, prognostic factors Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed cell surface and extracellular matrix (ECM) molecules consisting of a core protein covalently attached to the structurally complex glycosaminoglycan, heparan sulfate (HS ...
Andrew R. Clamp, Gordon C. Jayson
doaj +4 more sources
BiologicsHeparan sulfate proteoglycans are highly glycosylated proteins in which heparan sulfate, a glycosaminoglycan sugar chain, is an acidic sugar chain consisting of a repeating disaccharide structure of glucuronic acid and N-acetylglucosamine is locally ...
Yasunari Matsuzaka +2 more
exaly +3 more sources
Heparan Sulfate Proteoglycans in Human Colorectal Cancer [PDF]
Analytical Cellular Pathology, 2018 Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year. Prognosis of patients is highly dependent on the disease stage at diagnosis.
Carolina Meloni Vicente +7 more
doaj +2 more sources
Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function [PDF]
Frontiers in Cell and Developmental Biology, 2020 Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously expressed across tissues and have been found to exert a multitude of effects on cell behavior and ...
Maanasa Ravikumar +6 more
doaj +2 more sources