Results 21 to 30 of about 239,929 (209)
Profiling Heparan Sulfate Proteoglycans in Ovarian Carcinoma [PDF]
The Scientific World Journal, 2005 : heparan sulfate, proteoglycans, syndecan, glypican, perlecan, ovarian carcinoma, angiogenesis, prognostic factors Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed cell surface and extracellular matrix (ECM) molecules consisting of a core protein covalently attached to the structurally complex glycosaminoglycan, heparan sulfate (HS ...
Andrew R. Clamp, Gordon C. Jayson
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Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function [PDF]
Frontiers in Cell and Developmental Biology, 2020 Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously expressed across tissues and have been found to exert a multitude of effects on cell behavior and ...
Maanasa Ravikumar +6 more
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Microbial Subversion of Heparan Sulfate Proteoglycans
Molecules and Cells, 2008 The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment and subsequent cellular entry.
Pyong Woo Park, Martin Gotte
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Heparan sulfate proteoglycans present PCSK9 to the LDL receptor [PDF]
Nature Communications, 2017 PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation.
Camilla Gustafsen +13 more
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R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling [PDF]
eLife, 2020 R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4,
Ramin Dubey +12 more
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Heparan Sulfate Proteoglycans [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Stephane, Sarrazin +2 more
+7 more sources
Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity
Frontiers in Molecular Neuroscience, 2018 Neural circuits consist of distinct neuronal cell types connected in specific patterns. The specificity of these connections is achieved in a series of sequential developmental steps that involve the targeting of neurites, the identification of synaptic ...
Joris de Wit, Giuseppe Condomitti
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Heparan Sulfate Proteoglycans in Viral Infection and Treatment: A Special Focus on SARS-CoV-2 [PDF]
International Journal of Molecular Sciences, 2021 Valeria de Pasquale +2 more
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Heparan sulfate proteoglycans as targets for cancer therapy: a review [PDF]
Cancer Biology and Therapy, 2020 Jessica Onyeisi +2 more
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Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans [PDF]
EMBO Journal, 2021 Julia Eder +2 more
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