Results 21 to 30 of about 39,579 (251)

An Atlas of Heparan Sulfate Proteoglycans in the Postnatal Rat Lens. [PDF]

Invest Ophthalmol Vis Sci, 2021
Wishart TFL, Lovicu FJ.
europepmc   +2 more sources

Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function [PDF]

Frontiers in Cell and Developmental Biology, 2020
Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously expressed across tissues and have been found to exert a multitude of effects on cell behavior and ...
Maanasa Ravikumar, Maanasa Ravikumar, Raymond Alexander Alfred Smith, Victor Nurcombe, Victor Nurcombe, Simon M. Cool, Simon M. Cool   +6 more
doaj   +2 more sources

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling [PDF]

eLife, 2020
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4,
Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi   +12 more
doaj   +2 more sources

Heparan Sulfate Proteoglycans as Relays of Neuroinflammation. [PDF]

J Histochem Cytochem, 2018
Heparan sulfate proteoglycans (HSPGs) are implicated as inflammatory mediators in a variety of settings, including chemokine activation, which is required to recruit circulating leukocytes to infection sites. Heparan sulfate (HS) polysaccharide chains are highly interactive and serve co-receptor roles in multiple ligand:receptor interactions.
O'Callaghan P, Zhang X, Li JP.
europepmc   +6 more sources

Endocytosis and Trafficking of Heparan Sulfate Proteoglycans in Triple-Negative Breast Cancer Cells Unraveled with a Polycationic Peptide. [PDF]

Int J Mol Sci, 2020
Mandarini E, Tollapi E, Zanchi M, Depau L, Pini A, Brunetti J, Bracci L, Falciani C.   +7 more
europepmc   +3 more sources

Heparan Sulfate Proteoglycans [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Stephane, Sarrazin, William C, Lamanna, Jeffrey D, Esko   +2 more
openaire   +4 more sources

Heparan Sulfate Proteoglycans as Attachment Factor for SARS-CoV‑2 [PDF]

ACS Central Science, 2021
Lin Liu, Pradeep Chopra, Xiuru Li, Kim M. Bouwman, S. Mark Tompkins, Margreet A. Wolfert, Robert P. de Vries, Geert-Jan Boons   +7 more
doaj   +2 more sources

Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis.

Blood
Abstract From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology.
Piszczatowski RT, Bülow HE, Steidl U.
europepmc   +3 more sources

Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function

Matrix Biology Plus, 2022
The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular homeostasis.
Danielle Pretorius, Robert P. Richter, Tanya Anand, Jessica C. Cardenas, Jillian R. Richter   +4 more
doaj   +1 more source

Heparan Sulfate Proteoglycans in Viral Infection and Treatment: A Special Focus on SARS-CoV-2. [PDF]

Int J Mol Sci, 2021
De Pasquale V, Quiccione MS, Tafuri S, Avallone L, Pavone LM.   +4 more
europepmc   +2 more sources