Results 11 to 20 of about 255,399 (229)
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor [PDF]
Nature Communications, 2017 PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation.
Camilla Gustafsen +13 more
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Functions of Cell Surface Heparan Sulfate Proteoglycans
Annual Review of Biochemistry, 1999 ▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a large number of extracellular ligands. Members of both cell surface heparan sulfate proteoglycan families, the transmembrane syndecans and the glycosylphosphoinositide-linked glypicans, bind these ligands and enhance formation of their receptor-signaling ...
M, Bernfield +6 more
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R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling [PDF]
eLife, 2020 R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4,
Ramin Dubey +12 more
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Opticin Binds to Heparan and Chondroitin Sulfate Proteoglycans
Investigative Opthalmology & Visual Science, 2005 The extracellular matrix glycoprotein opticin is a small leucine-rich repeat proteoglycan/protein family member that was discovered associated with vitreous humor collagen fibrils. Opticin is present throughout the vitreous, but is particularly concentrated at the internal limiting lamina, where it colocalizes with type XVIII collagen.
Hindson, V. John +3 more
openaire +4 more sources
Heparan Sulfate Proteoglycans [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Stephane, Sarrazin +2 more
+7 more sources
Heparan sulfate proteoglycans as targets for cancer therapy: a review [PDF]
Cancer Biology and Therapy, 2020 Jessica Oyie Sousa Onyeisi +2 more
exaly +2 more sources
Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis.
BloodAbstract From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology.
Piszczatowski RT, Bülow HE, Steidl U.
europepmc +3 more sources
Heparan Sulfate Proteoglycans as Attachment Factor for SARS-CoV‑2 [PDF]
ACS Central Science, 2021 Lin Liu +7 more
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Heparan Sulfate Proteoglycans in Immunity. [PDF]
Proteoglycan ResABSTRACT In immune cells, heparin was first identified in mast cells in the 1940s, followed by the discovery of heparan sulfate in lymphocytes and granulocytes during the 1970s and 1980s. Subsequent decades of research have revealed how heparan sulfate and heparin, conjugated to core proteins as heparan sulfate proteoglycans (HSPGs ...
Iwai M, Park PW.
europepmc +2 more sources
Matrix Biology Plus, 2022 The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular homeostasis.
Danielle Pretorius +4 more
doaj +1 more source