Results 11 to 20 of about 239,929 (209)

Heparan Sulfate Proteoglycans in Tauopathy [PDF]

Biomolecules, 2022
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu, Lauren Gandy, Fuming Zhang, Jian Liu, Chunyu Wang, Laura J. Blair, Robert J. Linhardt, Lianchun Wang   +7 more
doaj   +6 more sources

Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression [PDF]

Frontiers in Endocrinology, 2018
Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate
Suresh Bugide, Parmanand Malvi, Arvindhan Nagarajan   +2 more
exaly   +5 more sources

Heparan sulfate proteoglycans in glomerular inflammation [PDF]

Kidney International, 2004
Heparan sulfate proteoglycans (HSPGs) are glycoproteins consisting of a core protein to which linear heparan sulfate side chains are covalently attached. These heparan sulfate side chains can be modified at different positions by several enzymes, which include N-deacetylases, N- and O-sulfotransferases, and an epimerase.
Johan van der Vlag, Toin van Kuppevelt, Lambertus van den Heuvel   +2 more
exaly   +8 more sources

Heparan Sulfate Proteoglycans in Human Colorectal Cancer [PDF]

Analytical Cellular Pathology, 2018
Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year. Prognosis of patients is highly dependent on the disease stage at diagnosis.
Carolina Meloni Vicente, Daiana Aparecida da Silva, Priscila Veronica Sartorio, Tiago Donizetti Silva, Sarhan Sydney Saad, Helena Bonciani Nader, Nora Manoukian Forones, Leny Toma   +7 more
doaj   +3 more sources

Classification and Molecular Functions of Heparan Sulfate Proteoglycans and Their Molecular Mechanisms with the Receptor

Biologics
Heparan sulfate proteoglycans are highly glycosylated proteins in which heparan sulfate, a glycosaminoglycan sugar chain, is an acidic sugar chain consisting of a repeating disaccharide structure of glucuronic acid and N-acetylglucosamine is locally ...
Yasunari Matsuzaka, Ryu Yashiro
exaly   +4 more sources

A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors [PDF]

Frontiers in Immunology, 2021
While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell receptors with non-conventional ligands, particularly carbohydrate antigens, is less well ...
Klara Klein, Klara Klein, Klara Klein, Angelique Hölzemer, Angelique Hölzemer, Angelique Hölzemer, Tim Wang, Tim Wang, Tim Wang, Tae-Eun Kim, Haley L. Dugan, Haley L. Dugan, Stephanie Jost, Stephanie Jost, Marcus Altfeld, Wilfredo F. Garcia-Beltran, Wilfredo F. Garcia-Beltran   +16 more
doaj   +2 more sources

Heparan sulfate proteoglycans and cancer [PDF]

British Journal of Cancer, 2001
Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached.
Blackhall, F. H.; id_orcid 0000-0001-8716-3395, Merry, C. L R, Davies, E. J., Jayson, G. C.; id_orcid 0000-0002-8515-8944   +3 more
openaire   +3 more sources

Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis.

Blood
Abstract From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology.
Piszczatowski RT, Bülow HE, Steidl U.
europepmc   +3 more sources

Heparan Sulfate Proteoglycans in Immunity. [PDF]

Proteoglycan Res
ABSTRACT In immune cells, heparin was first identified in mast cells in the 1940s, followed by the discovery of heparan sulfate in lymphocytes and granulocytes during the 1970s and 1980s. Subsequent decades of research have revealed how heparan sulfate and heparin, conjugated to core proteins as heparan sulfate proteoglycans (HSPGs ...
Iwai M, Park PW.
europepmc   +2 more sources

Heparan Sulfate Proteoglycans as Relays of Neuroinflammation. [PDF]

J Histochem Cytochem, 2018
Heparan sulfate proteoglycans (HSPGs) are implicated as inflammatory mediators in a variety of settings, including chemokine activation, which is required to recruit circulating leukocytes to infection sites. Heparan sulfate (HS) polysaccharide chains are highly interactive and serve co-receptor roles in multiple ligand:receptor interactions.
O'Callaghan P, Zhang X, Li JP.
europepmc   +4 more sources