Results 11 to 20 of about 20,328 (148)

Microbial Subversion of Heparan Sulfate Proteoglycans

Molecules and Cells, 2008
The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment and subsequent cellular entry.
Martin Gotte, Pyong Woo Park
exaly   +4 more sources

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling [PDF]

eLife, 2020
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4,
Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi   +12 more
doaj   +2 more sources

Heparan sulfate proteoglycans as targets for cancer therapy: a review [PDF]

Cancer Biology and Therapy, 2020
Jessica Oyie Sousa Onyeisi, Helena B Nader, Carla Cristina Lopes   +2 more
exaly   +2 more sources

Heparan Sulfate Proteoglycans [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Stephane, Sarrazin, William C, Lamanna, Jeffrey D, Esko   +2 more
openaire   +4 more sources

Heparan Sulfate Proteoglycans in Viral Infection and Treatment: A Special Focus on SARS-CoV-2 [PDF]

International Journal of Molecular Sciences, 2021
Valeria De Pasquale, Simona Tafuri, Luigi Avallone   +2 more
exaly   +2 more sources

Heparan Sulfate Proteoglycans as Attachment Factor for SARS-CoV‑2 [PDF]

ACS Central Science, 2021
Lin Liu, Pradeep Chopra, Xiuru Li, Kim M. Bouwman, S. Mark Tompkins, Margreet A. Wolfert, Robert P. de Vries, Geert-Jan Boons   +7 more
doaj   +2 more sources

Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function

Matrix Biology Plus, 2022
The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular homeostasis.
Danielle Pretorius, Robert P. Richter, Tanya Anand, Jessica C. Cardenas, Jillian R. Richter   +4 more
doaj   +1 more source

Heparan Sulfate: A Regulator of White Adipocyte Differentiation and of Vascular/Adipocyte Interactions

Biomedicines, 2022
White adipose tissues are major endocrine organs that release factors, termed adipokines, which affect other major organ systems. The development and functions of adipose tissues depend largely upon the glycosaminoglycan heparan sulfate.
J. Michael Sorrell, Arnold I. Caplan
doaj   +1 more source

Agrin Is a Heparan Sulfate Proteoglycan [PDF]

Journal of Biological Chemistry, 1995
In the present study we have identified the extracellular matrix protein agrin as a major heparan sulfate proteoglycan (HSPG) in embryonic chick brain. Using monoclonal antibodies and a polyclonal antiserum to the core protein of a previously identified HSPG from embryonic chick brain, our expression screened a random-primed E9 chick brain cDNA library.
G, Tsen, W, Halfter, S, Kröger, G J, Cole   +3 more
openaire   +2 more sources

Heparan sulfate proteoglycans at a glance [PDF]

Journal of Cell Science, 2007
Proteoglycans are abundant components of the cell surface and extracellular matrix that mediate critical interactions between cells and their environment. They play a variety of biological roles in normal tissues and in response to injury and disease.
Catherine A, Kirkpatrick, Scott B, Selleck   +1 more
openaire   +2 more sources