Results 41 to 50 of about 255,399 (229)

Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-β [PDF]

, 2014
Macrophages are important mediators of diseases associated with metabolic inflammation such as obesity and atherosclerosis. In this Stimulus we discuss recent findings showing that heparan sulfate proteoglycans on macrophages serve as an important ...
Gordts, Philip LSM, Esko, Jeffrey D, Gordts, PLSM, Esko, JD   +3 more
core   +2 more sources

The Nature of Cell‐Penetrating Poly(disulfide)s

Angewandte Chemie, EarlyView.
The mode of action of cell‐penetrating poly(disulfide)s (CPDs) is elucidated to understand thiol‐mediated uptake (TMU) in general and guide future efforts to control cellular entry for chemicals delivery and pathogen defense. ABSTRACT Cell‐penetrating poly(disulfide)s (CPDs) are the most popular thiol‐mediated uptake (TMU) tools for delivering attached
Saidbakhrom Saidjalolov, Giacomo Renno, Yuheng Zhang, Michael Cognet, Justin Neuman, Andreas Hennig, Naomi Sakai, Stefan Matile   +7 more
wiley   +2 more sources

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

Scientific Reports, 2017
Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse, Hodaka Yamakado, Xander M. van Wijk, Roger Lawrence, Jeffrey D. Esko, Eliezer Masliah   +5 more
doaj   +1 more source

Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth

Neoplasia: An International Journal for Oncology Research, 2016
In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However, little is known regarding the genetic and functional importance of glycan chains displayed by ...
Roland El Ghazal, Xin Yin, Scott C. Johns, Lee Swanson, Monica Macal, Pradipta Ghosh, Elina I. Zuniga, Mark M. Fuster   +7 more
doaj   +1 more source

Heparan Sulfate Proteoglycan Signaling in Tumor Microenvironment [PDF]

International Journal of Molecular Sciences, 2020
In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an intriguing subject of study for their complex structural characteristics, their finely regulated biosynthetic machinery, and the wide range of functions they perform in living organisms from development to adulthood.
De Pasquale, Valeria, Pavone, Luigi Michele   +1 more
openaire   +3 more sources

Heparan sulfate proteoglycans: structure, protein interactions and cell signaling

Anais da Academia Brasileira de Ciências, 2009
Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species. This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions ...
Juliana L. Dreyfuss, Caio V. Regatieri, Thais R. Jarrouge, Renan P. Cavalheiro, Lucia O. Sampaio, Helena B. Nader   +5 more
doaj   +1 more source

Inhibition of Heparan Sulfate and Chondroitin Sulfate Proteoglycan Biosynthesis [PDF]

Journal of Biological Chemistry, 2008
Proteoglycans (PGs) are composed of a protein moiety and a complex glycosaminoglycan (GAG) polysaccharide moiety. GAG chains are responsible for various biological activities. GAG chains are covalently attached to serine residues of the core protein. The first step in PG biosynthesis is xylosylation of certain serine residues of the core protein.
Dinesh R, Garud, Vy M, Tran, Xylophone V, Victor, Mamoru, Koketsu, Balagurunathan, Kuberan   +4 more
openaire   +2 more sources

Regulation of FGF10 Signaling in Development and Disease

Frontiers in Genetics, 2018
Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults.
Joanne Watson, Joanne Watson, Chiara Francavilla   +2 more
doaj   +1 more source

Proteoglycans act as cellular hepatitis delta virus attachment receptors. [PDF]

PLoS ONE, 2013
The hepatitis delta virus (HDV) is a small, defective RNA virus that requires the presence of the hepatitis B virus (HBV) for its life cycle. Worldwide more than 15 million people are co-infected with HBV and HDV.
Oscar Lamas Longarela, Tobias T Schmidt, Katrin Schöneweis, Raffaella Romeo, Heiner Wedemeyer, Stephan Urban, Andreas Schulze   +6 more
doaj   +1 more source

APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans. [PDF]

, 2021
Atherosclerotic cardiovascular disease causes heart attacks and strokes, which are the leading causes of mortality worldwide1. The formation of atherosclerotic plaques is initiated when low-density lipoproteins bind to heparan-sulfate proteoglycans ...
Simon, Tabassome, Kubicek, Stefan, Scharnagl, Hubert, Jørgensen, Helle F, Smeets, D., Afonyushkin, T., Fogelstrand, Per,, Jorgensen, H. F., Porsch, Florentina, Ozsvar-Kozma, Maria, Frommlet, Florian, Weißer, Juliane, Mayer, F. J., März, Winfried, Fogelstrand, Per, Hess, Henry, Tsiantoulas, D., Borén, Jan, Binder, Christoph J, Danchin, N., Smeets, Diede, Enders, Lennart, Danchin, Nicolas, Schneider, P., Pasterkamp, Gerard, Porsch, F., Kiss, M. G., Hendrikx, T., Lambert, J., Borén, Jan,, Eslami, M., Murphy, J. E., Simon, T., Lambert, Jordi, Göderle, Laura, Murphy, Jane E, Frommlet, F., Donzé, Olivier, Hess, H., Hoke, Matthias, Binder, C. J., Eslami, Mahya, Mallat, Z., Enders, L., Donze, O., Willen, L., Hoke, M., Mallat, Ziad, Goderle, L., Mayer, Florian J, Hendrikx, Tim, Willen, Laure, Afonyushkin, Taras, Mueller, A., Obermayer, Georg, Weisser, J., Ozsvar-Kozma, M., Marz, W., Kiss, Máté G, Mueller, André, Scharnagl, H., Tsiantoulas, Dimitrios, Obermayer, G., Clement, M., Schneider, Pascal, Pasterkamp, G., Kubicek, S., Clement, Marc, Jørgensen, H.F., Murphy, J.E., Fogelstrand, P., Borén, J., Circulatory Health, Mayer, F.J., Binder, C.J., Centraal Diagnostisch Laboratorium, Kiss, M.G., Florian J. Mayer, Tim Hendrikx, Henry Hess, Georg Obermayer, Matthias Hoke, Lennart Enders, Per Fogelstrand, Dimitrios Tsiantoulas, Máté G. Kiss, Stefan Kubicek, Florentina Porsch, Maria Ozsvar-Kozma, Laure Willen, André Mueller, Pascal Schneider, Nicolas Danchin, Laura Göderle, Jane E. Murphy, Helle F. Jørgensen, Gerard Pasterkamp, Diede Smeets, Olivier Donzé, Mahya Eslami, Taras Afonyushkin, Marc Clement, Tabassome Simon, Ziad Mallat, Winfried März, Jordi Lambert, Hubert Scharnagl, Jan Borén, Florian Frommlet, Juliane Weißer, Christoph J. Binder   +110 more
core   +2 more sources