Results 41 to 50 of about 23,189 (236)
Scientific Reports, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse +5 more
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Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth
Neoplasia: An International Journal for Oncology Research, 2016 In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However, little is known regarding the genetic and functional importance of glycan chains displayed by ...
Roland El Ghazal +7 more
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, 2014 Heparan sulfate proteoglycans (HSPGs) play critical roles in the development and adult physiology of all metazoan organisms. Most of the known molecular interactions of HSPGs are attributed to the structurally highly complex heparan sulfate (HS) glycans.
Kinnunen, Tarja K. +4 more
core +1 more source
Inhibition of Heparan Sulfate and Chondroitin Sulfate Proteoglycan Biosynthesis [PDF]
Journal of Biological Chemistry, 2008 Proteoglycans (PGs) are composed of a protein moiety and a complex glycosaminoglycan (GAG) polysaccharide moiety. GAG chains are responsible for various biological activities. GAG chains are covalently attached to serine residues of the core protein. The first step in PG biosynthesis is xylosylation of certain serine residues of the core protein.
Dinesh R, Garud +4 more
openaire +2 more sources
Regulation of FGF10 Signaling in Development and Disease
Frontiers in Genetics, 2018 Fibroblast Growth Factor 10 (FGF10) is a multifunctional mesenchymal-epithelial signaling growth factor, which is essential for multi-organ development and tissue homeostasis in adults.
Joanne Watson +2 more
doaj +1 more source
Proteoglycans act as cellular hepatitis delta virus attachment receptors. [PDF]
PLoS ONE, 2013 The hepatitis delta virus (HDV) is a small, defective RNA virus that requires the presence of the hepatitis B virus (HBV) for its life cycle. Worldwide more than 15 million people are co-infected with HBV and HDV.
Oscar Lamas Longarela +6 more
doaj +1 more source
, 2020 In recent decades, evidence has accumulated implicating heparan sulfate proteoglycans (HSPGs) in tumor initiation and progression. Ubiquitously present at the cell surface and in the extracellular matrix, HSPGs are composed of a protein core with ...
core +2 more sources
BMC Cell Biology, 2001 Background The first type III repeat of fibronectin is known to be involved in fibronectin matrix assembly, and recombinant proteins from this type III repeat can inhibit cell proliferation, tumor metastasis and angiogenesis. We have analyzed the way rat
Morla Alex O, Mercurius Kwesi O
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Developmental roles of heparan sulfate proteoglycans in Drosophila [PDF]
Glycoconjugate Journal, 2002 The formation of complex patterns in multi-cellular organisms is regulated by a number of signaling pathways. In particular, the Wnt and Hedgehog (Hh) pathways have been identified as critical organizers of pattern in many tissues. Although extensive biochemical and genetic studies have elucidated the central components of the signal transduction ...
Xinhua, Lin, Norbert, Perrimon
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, 2014 Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Schroeder, N +6 more
core +1 more source