Results 31 to 40 of about 39,579 (251)

Heparan Sulfate: A Regulator of White Adipocyte Differentiation and of Vascular/Adipocyte Interactions

Biomedicines, 2022
White adipose tissues are major endocrine organs that release factors, termed adipokines, which affect other major organ systems. The development and functions of adipose tissues depend largely upon the glycosaminoglycan heparan sulfate.
J. Michael Sorrell, Arnold I. Caplan
doaj   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Combinatorial Roles of Heparan Sulfate Proteoglycans and Heparan Sulfates in Caenorhabditis elegans Neural Development [PDF]

, 2014
Heparan sulfate proteoglycans (HSPGs) play critical roles in the development and adult physiology of all metazoan organisms. Most of the known molecular interactions of HSPGs are attributed to the structurally highly complex heparan sulfate (HS) glycans.
AN Minniti, B Casu, BD Ackley, BT Kim, C Desai, C Rhiner, CL Merry, DR Ferro, H Habuchi, H Kitagawa, H Kitagawa, H Kitagawa, H Morio, HE Bulow, HE Bulow, HE Bulow, J Aikawa, J Li, JP Li, JR Bishop, JY Sze, K Holmborn, KL Kramer, M Zako, ML Hudson, MM Shah, MM Shah, Nikos K. Karamanos, NW Shworak, RA Townley, S Brenner, S Tumova, SG Clark, SL Bullock, T Kinnunen, T Kinnunen, T Lind, Tarja K. Kinnunen, TL Gumienny, TM Rogalski, TR Rudd, UM Polanska   +41 more
core   +12 more sources

Heparan sulfate proteoglycans as targets for cancer therapy: a review. [PDF]

Cancer Biol Ther, 2020
Onyeisi JOS, Ferreira BZF, Nader HB, Lopes CC.   +3 more
europepmc   +2 more sources

Profiling Heparan Sulfate Proteoglycans in Ovarian Carcinoma [PDF]

The Scientific World Journal, 2005
: heparan sulfate, proteoglycans, syndecan, glypican, perlecan, ovarian carcinoma, angiogenesis, prognostic factors Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed cell surface and extracellular matrix (ECM) molecules consisting of a core protein covalently attached to the structurally complex glycosaminoglycan, heparan sulfate (HS ...
Andrew R. Clamp, Gordon C. Jayson
doaj   +4 more sources

Heparan sulfate proteoglycans and cancer [PDF]

British Journal of Cancer, 2001
Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached.
Blackhall, F. H., Merry, C. L R, Davies, E. J., Jayson, G. C.   +3 more
openaire   +2 more sources

Heparan sulfate proteoglycans at a glance [PDF]

Journal of Cell Science, 2007
Proteoglycans are abundant components of the cell surface and extracellular matrix that mediate critical interactions between cells and their environment. They play a variety of biological roles in normal tissues and in response to injury and disease.
Catherine A, Kirkpatrick, Scott B, Selleck   +1 more
openaire   +2 more sources

Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin

Journal of Inflammation, 2006
Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology.
Patsch Josef R, Ricevuti Giovanni, Ross Christopher R, Kaneider Nicole C, Mosheimer Birgit, Djanani Angela, Wiedermann Christian J   +6 more
doaj   +1 more source

Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity

Molecules, 2020
Glycosylation is a common and widespread post-translational modification that affects a large majority of proteins. Of these, a small minority, about 20, are specifically modified by the addition of heparan sulfate, a linear polysaccharide from the ...
Thibault Annaval, Rebekka Wild, Yoann Crétinon, Rabia Sadir, Romain R. Vivès, Hugues Lortat-Jacob   +5 more
doaj   +1 more source