Wingless, Hedgehog and Heparan Sulfate Proteoglycans [PDF]
Development, 2004 Several recent papers published in Development challenge some of the previous views published by our group and others that: (1) the Drosophila glypican molecules Dally and Dally-like protein (Dlp) are involved in Wingless (Wg) signaling; and (2) Tout-velu/Ext/Ttv affects Hedgehog (Hh) but not ...
Norbert, Perrimon, Udo, Häcker
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Identification of function-regulating antibodies targeting the receptor protein tyrosine phosphatase sigma ectodomain. [PDF]
PLoS ONE, 2017 Receptor tyrosine phosphatase sigma (RPTPσ) plays an important role in the regulation of axonal outgrowth and neural regeneration. Recent studies have identified two RPTPσ ligands, chondroitin sulfate proteoglycans (CSPGs) and heparan sulfate ...
Chia-Lun Wu +6 more
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Expression Pattern of Sulf1 and Sulf2 in Chicken Tissues and Characterization of Their Expression During Different Periods in Skeletal Muscle Satellite Cells [PDF]
Brazilian Journal of Poultry ScienceHeparan sulfate proteoglycans (HSPGs) are present on the cell surface and in the extracellular matrix in all metazoans. HSPGs interact with growth factors and receptors through heparan sulfate (HS) chains.
L He +8 more
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Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. [PDF]
PLoS ONE, 2010 Lipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulation, liberating free fatty acids for energy metabolism or storage.
Joseph R Bishop +10 more
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Cardiovascular Diabetology, 2004 Background Arterial proteoglycans are implicated in the pathogenesis of atherosclerosis by their ability to trap plasma lipoproteins in the arterial wall and by their influence on cellular migration, adhesion and proliferation.
Litwak Kenneth N +4 more
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Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis
Frontiers in Genetics, 2021 Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan sulfate are covalently attached to specific core proteins to form proteoglycans, which are distributed at the cell surface as well as in the extracellular matrix ...
Shuji Mizumoto, Shuhei Yamada
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Effect of epithelial debridement on human cornea proteoglycans
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
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Heparan Sulfate Proteoglycan Signaling in Tumor Microenvironment [PDF]
International Journal of Molecular Sciences, 2020 In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an intriguing subject of study for their complex structural characteristics, their finely regulated biosynthetic machinery, and the wide range of functions they perform in living organisms from development to adulthood.
De Pasquale, Valeria +1 more
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Heparan sulfate proteoglycans can promote opposite effects on adhesion and directional migration of different cancer cells [PDF]
, 2020 Heparan sulfate proteoglycans take part in crucial events of cancer progression, such as epithelial-mesenchymal transition, cell migration, and cell invasion.
Bracci L. +9 more
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Frontiers in Immunology, 2020 Sexually transmitted Hepatitis C virus (HCV) infections and high reinfections are a major concern amongst men who have sex with men (MSM) living with HIV-1 and HIV-negative MSM.
Bernadien M. Nijmeijer +8 more
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