Results 41 to 50 of about 211,407 (207)
Structural Analysis of Heparan Sulfate and Heparan Sulfate Oligosaccharides.
Trends in Glycoscience and Glycotechnology, 1998 ヘパラン硫酸は構造的に複雑な生体内高分子で、様々な重要な生物活性発現に関わる可能性が認められ、最近活発に研究されるようになった。ヘパラン硫酸の生物活性発現はグリコサミノグリカン糖鎖による。このグリコサミノグリカンは、複雑な構造多様性を示す二糖単位から構成され、その糖鎖長も一定でない。この複雑な糖鎖を構造決定しようとする試みは、あらゆる方法を用いて遂行されたにもかかわらず、未だ達成されていない。最近のヘパラン硫酸糖鎖構造に関する研究は、もっぱらある種の生物活性を示す最小糖鎖配列を高分子部分から切り出し、その構造を同定することに焦点が絞られている。このミニレビューでは、ヘパラン硫酸由来のオリゴ糖鎖の調製、単離および構造決定法について最近の文献を挙げ、総説する。特に、高速液体クロマトグラフィー ...
Toida, Toshihiko, Linhardt, R. J.
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Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]
, 2004 Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Guimond, S +17 more
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Frontiers in Physiology, 2018 The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular ...
M. F. Galvis-Ramírez +2 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2020 Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair.
Claire Reynolds-Peterson +11 more
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Graft glycocalyx degradation in human liver transplantation.
PLoS ONE, 2019 ObjectiveIschaemia/reperfusion-injury degrades endothelial glycocalyx. Graft glycocalyx degradation was studied in human liver transplantation.MethodsTo assess changes within the graft, blood was drawn from portal and hepatic veins in addition to ...
Arie Passov +6 more
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Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase [PDF]
, 2010 Heparanase is a heparan sulfate (HS) degrading endoglucuronidase that has been implicated in cell migration and inflammatory conditions. Here we used mice deficient of heparanase (Hpse−/−) to study the impact of heparanase on airway leukocytes.
Vlodavsky, Israel +12 more
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Molecules, 2017 Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine.
Ha Na Kim +2 more
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Bio-Protocol, 2017 Heparan sulfate (HS) is purified from complex matrices and often not fully characterised to validate its assignment. The characterisation of heparins and heparan sulfates through enzymatic depolymerisation and subsequent strong anion-exchange high ...
Susan Carnachan, Simon F.R. Hinkley
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Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis
BloodAbstract From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology.
Richard T. Piszczatowski +2 more
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Chemistry and biology of heparin and heparan sulfate /
, 2005 The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan
Garg, Hari G. +2 more
core +2 more sources