Results 41 to 50 of about 79,508 (247)
Frontiers in Physiology, 2018 The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular ...
M. F. Galvis-Ramírez +2 more
doaj +1 more source
Glycosaminoglycans in the human cornea: age-related changes [PDF]
, 2015 AIM: To investigate possible age-related changes in glycosaminoglycans (GAGs) in the human cornea. The substances today called GAGs were previously referred to as mucopolysaccharides.
Anello, Giulia +6 more
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Molecules, 2017 Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine.
Ha Na Kim +2 more
doaj +1 more source
Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. [PDF]
, 2006 Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic ...
Bishop, Joseph R +4 more
core +2 more sources
Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor [PDF]
, 2013 Enterovirus 71 (EV-71) infections are usually associated with mild hand, foot, and mouth disease in young children but have been reported to cause severe neurological complications with high mortality rates.
Chan, Yoke Fun +3 more
core +1 more source
Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation [PDF]
Proceedings of the National Academy of Sciences, 2008 Heparan sulfate (HS) proteoglycans influence embryonic development and adult physiology through interactions with protein ligands. The interactions depend on HS structure, which is determined largely during biosynthesis by Golgi enzymes. How biosynthesis is regulated is more or less unknown.
Jenny, Presto +7 more
openaire +2 more sources
Bio-Protocol, 2017 Heparan sulfate (HS) is purified from complex matrices and often not fully characterised to validate its assignment. The characterisation of heparins and heparan sulfates through enzymatic depolymerisation and subsequent strong anion-exchange high ...
Susan Carnachan, Simon F.R. Hinkley
doaj +1 more source
The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation [PDF]
, 2007 Background: Shear stress induces coronary dilatation via production of nitric oxide ( NO). This should involve the endothelial glycocalyx ( EG). A greater effect was expected of albumin versus hydroxyethyl starch ( HES) perfusion, because albumin seals ...
Bernhard F. Becker +25 more
core +1 more source
Structural Analysis of Heparan Sulfate and Heparan Sulfate Oligosaccharides.
Trends in Glycoscience and Glycotechnology, 1998 ヘパラン硫酸は構造的に複雑な生体内高分子で、様々な重要な生物活性発現に関わる可能性が認められ、最近活発に研究されるようになった。ヘパラン硫酸の生物活性発現はグリコサミノグリカン糖鎖による。このグリコサミノグリカンは、複雑な構造多様性を示す二糖単位から構成され、その糖鎖長も一定でない。この複雑な糖鎖を構造決定しようとする試みは、あらゆる方法を用いて遂行されたにもかかわらず、未だ達成されていない。最近のヘパラン硫酸糖鎖構造に関する研究は、もっぱらある種の生物活性を示す最小糖鎖配列を高分子部分から切り出し、その構造を同定することに焦点が絞られている。このミニレビューでは、ヘパラン硫酸由来のオリゴ糖鎖の調製、単離および構造決定法について最近の文献を挙げ、総説する。特に、高速液体クロマトグラフィー ...
Toshihiko Toida, R. J. Linhardt
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Bioengineered heparins and heparan sulfates [PDF]
Advanced Drug Delivery Reviews, 2016 Heparin and heparan sulfates are closely related linear anionic polysaccharides, called glycosaminoglycans, which exhibit a number of important biological and pharmacological activities. These polysaccharides, having complex structures and polydispersity, are biosynthesized in the Golgi of animal cells.
Li, Fu +2 more
openaire +2 more sources