Results 41 to 50 of about 41,050 (163)

Heparan Sulfate Polymerization in Drosophila [PDF]

Journal of Biological Chemistry, 2006
The formation of heparan sulfate (HS) chains is catalyzed by glycosyltransferases encoded by EXT (hereditary multiple exostosin gene) family members. Genetic screening for mutations affecting morphogen signaling pathways in Drosophila has identified three genes, tout-velu (ttv), sister of tout-velu (sotv), and brother of toutvelu (botv), which encode ...
Tomomi, Izumikawa, Noriyuki, Egusa, Fumiyasu, Taniguchi, Kazuyuki, Sugahara, Hiroshi, Kitagawa   +4 more
openaire   +2 more sources

Expression Pattern of Sulf1 and Sulf2 in Chicken Tissues and Characterization of Their Expression During Different Periods in Skeletal Muscle Satellite Cells [PDF]

Brazilian Journal of Poultry Science
Heparan sulfate proteoglycans (HSPGs) are present on the cell surface and in the extracellular matrix in all metazoans. HSPGs interact with growth factors and receptors through heparan sulfate (HS) chains.
L He, H Xu, F Ye, H Yu, Y Lu, H Yin, X Zhao, Q Zhu, Y Wang   +8 more
doaj   +2 more sources

Heparan sulfate is a plasma biomarker of acute cellular allograft rejection.

PLoS ONE, 2018
Despite advances in management of immunosuppression, graft rejection remains a significant clinical problem in solid organ transplantation. Non-invasive biomarkers of graft rejection can facilitate earlier diagnosis and treatment of acute rejection.
Andrew S Barbas, Liwen Lin, MacKenzie McRae, Andrea L MacDonald, Tracy Truong, Yiping Yang, Todd V Brennan   +6 more
doaj   +1 more source

Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation

Critical Care, 2019
Background Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury.
Joseph A. Hippensteel, Ryo Uchimido, Patrick D. Tyler, Ryan C. Burke, Xiaorui Han, Fuming Zhang, Sarah A. McMurtry, James F. Colbert, Christopher J. Lindsell, Derek C. Angus, John A. Kellum, Donald M. Yealy, Robert J. Linhardt, Nathan I. Shapiro, Eric P. Schmidt   +14 more
doaj   +1 more source

A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors

Frontiers in Immunology, 2021
While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell receptors with non-conventional ligands, particularly carbohydrate antigens, is less well ...
Klara Klein, Klara Klein, Klara Klein, Angelique Hölzemer, Angelique Hölzemer, Angelique Hölzemer, Tim Wang, Tim Wang, Tim Wang, Tae-Eun Kim, Haley L. Dugan, Haley L. Dugan, Stephanie Jost, Stephanie Jost, Marcus Altfeld, Wilfredo F. Garcia-Beltran, Wilfredo F. Garcia-Beltran   +16 more
doaj   +1 more source

Isolation and Characterization of a Chinese Hamster Ovary Heparan Sulfate Cell Mutant Defective in Both Met Receptor Binding and Hepatocyte Growth Factor NK1/Met Signaling

Cellular Physiology and Biochemistry, 2018
Background/Aims: The up-regulation of hepatocyte growth factor/receptor, HGF/Met, signal transduction is observed in most of human cancers. Specific heparan sulfate structures enhance the HGF/Met signaling at both cell and animal-based model systems ...
Tong Cao, Jing Pan, Xiulian Li, Yanli He, Yifei Jiang, Yajing Chang, Qi Zhang, Ying Lan, Hua Wang, Wenjie Jiao, Zibin Tian, Lijuan Zhang   +11 more
doaj   +1 more source

Heparan Sulfate Biosynthesis [PDF]

Journal of Histochemistry & Cytochemistry, 2012
Nearly all vertebrate cells have been shown to express heparan sulfate proteoglycans (HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including numerous growth factors, cytokines, and morphogens, to affect their tissue distribution and signaling.
Kreuger J, Kjellén L
openaire   +3 more sources

Cell-to-cell transmission of p53 aggregates: a novel player in oncology?

Molecular & Cellular Oncology, 2021
The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear.
Naoyuki Iwahashi, Midori Ikezaki, Hiroyuki Saito, Kenji Uchimura, Kazuchika Nishitsuji   +4 more
doaj   +1 more source

The Enzymatic Degradation of Heparan Sulfate [PDF]

Protein & Peptide Letters, 2017
Glycosaminoglycans (GAGs) such as heparan sulfate (HS) interact with a number of factors in the extracellular matrix (ECM) and as a consequence play a key role in the metabolic processes occurring within the cell. The dynamic synthesis and degradation of HS (and all GAGs) are necessary for ensuring that optimal chains are present for these functions ...
Griffin, Laura Susan, Gloster, Tracey Maureen   +1 more
openaire   +3 more sources

Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp

BMC Microbiology, 2008
Background The histone-like Hlp protein is emerging as a key component in mycobacterial pathogenesis, being involved in the initial events of host colonization by interacting with laminin and glycosaminoglycans (GAGs).
Previato Jose O, Mendonça-Previato Lucia, Ottenhoff Tom HM, Mohana-Borges Ronaldo, Silva Carlos AM, de Lima Cristiana S, Todeschini Adriane R, Portugal Michelle I, Pessolani Maria CV   +8 more
doaj   +1 more source