Results 11 to 20 of about 79,508 (247)
Heparan sulfates and heparan sulfate binding proteins in sepsis
Frontiers in Molecular Biosciences, 2023 Heparan sulfates (HSs) are the main components in the glycocalyx which covers endothelial cells and modulates vascular homeostasis through interactions with multiple Heparan sulfate binding proteins (HSBPs).
Yi-En Liao, Jian Liu, Katelyn Arnold
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Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type [PDF]
Scientific Reports, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse +5 more
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Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2 [PDF]
mBioSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants have acquired enhanced infectivity compared to earlier variants. To elucidate the underlying molecular mechanisms, we conducted CRISPR library screening to identify cell ...
Shuhei Higuchi +14 more
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Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor [PDF]
BMC Cell Biology, 2009 Background Nuclear localization of proteolytically formed intracellular fragment of ErbB4 receptor tyrosine kinase has been shown to promote cell survival, and nuclear localization of ErbB4 receptor has been described in human breast cancer.
Tuittila Minna T +5 more
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Heparan Sulfate Proteoglycans in Tauopathy
Biomolecules, 2022 Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu +7 more
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Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling [PDF]
Brazilian Journal of Medical and Biological Research, 2006 The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a
C.C. Lopes, C.P. Dietrich, H.B. Nader
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Heparan sulfate and cell division [PDF]
Brazilian Journal of Medical and Biological Research, 1999 Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic ...
Porcionatto M.A. +2 more
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Heparan Sulfate Proteoglycans [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Stephane, Sarrazin +2 more
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Heparin Mimetics and Their Impact on Extracellular Matrix Protein Assemblies
Pharmaceuticals, 2023 Heparan sulfate is a crucial extracellular matrix component that organizes structural features and functional protein processes. This occurs through the formation of protein–heparan sulfate assemblies around cell surfaces, which allow for the deliberate ...
Fabian Heide +2 more
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Combinatorial Roles of Heparan Sulfate Proteoglycans and Heparan Sulfates in Caenorhabditis elegans Neural Development [PDF]
, 2014 Heparan sulfate proteoglycans (HSPGs) play critical roles in the development and adult physiology of all metazoan organisms. Most of the known molecular interactions of HSPGs are attributed to the structurally highly complex heparan sulfate (HS) glycans.
AN Minniti +41 more
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