Results 11 to 20 of about 211,407 (207)
Heparan sulfates and heparan sulfate binding proteins in sepsis [PDF]
Frontiers in Molecular Biosciences, 2023 Heparan sulfates (HSs) are the main components in the glycocalyx which covers endothelial cells and modulates vascular homeostasis through interactions with multiple Heparan sulfate binding proteins (HSBPs).
Yi-En Liao, Jian Liu, Katelyn Arnold
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Heparan Sulfate Proteoglycans in Tauopathy [PDF]
Biomolecules, 2022 Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Yanan Zhu +7 more
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Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression [PDF]
Frontiers in Endocrinology, 2018 Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains. Proteins with covalently bound Heparan sulfate chains are termed Heparan Sulfate
Arvindhan Nagarajan +3 more
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Heparan sulfate and cell division [PDF]
Brazilian Journal of Medical and Biological Research, 1999 Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic ...
Porcionatto M.A. +2 more
doaj +9 more sources
Heparan sulfate signaling in cancer [PDF]
Trends in Biochemical Sciences, 2014 Heparan sulfate (HS) is a biopolymer consisting of variably sulfated repeating disaccharide units. The anticoagulant heparin is a highly sulfated intracellular variant of HS. HS has demonstrated roles in embryonic development, homeostasis, and human disease via non-covalent interactions with numerous cellular proteins, including growth factors and ...
Gérard Blobe, Erik Knelson
exaly +3 more sources
Heparan Sulfate Biosynthesis [PDF]
Journal of Histochemistry and Cytochemistry, 2012 Nearly all vertebrate cells have been shown to express heparan sulfate proteoglycans (HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including numerous growth factors, cytokines, and morphogens, to affect their tissue distribution and signaling.
Johan Kreuger, Lena Kjellen
exaly +4 more sources
Heparan Sulfate-Dependent Enhancement of Henipavirus Infection
mBio, 2015 Nipah virus and Hendra virus are emerging, highly pathogenic, zoonotic paramyxoviruses that belong to the genus Henipavirus. They infect humans as well as numerous mammalian species.
Cyrille Mathieu +9 more
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NeuroprotectionHeparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and neuroprotection. The ability of heparan sulfate to promote
Mozammel H. Bhuiyan +3 more
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Heparin Mimetics and Their Impact on Extracellular Matrix Protein Assemblies
Pharmaceuticals, 2023 Heparan sulfate is a crucial extracellular matrix component that organizes structural features and functional protein processes. This occurs through the formation of protein–heparan sulfate assemblies around cell surfaces, which allow for the deliberate ...
Fabian Heide +2 more
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Heparan Sulfate Proteoglycans [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions.
Stephane, Sarrazin +2 more
openaire +2 more sources