Results 1 to 10 of about 27,782 (234)

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity [PDF]

Biomolecules, 2020
This review examines aggrecan’s roles in developmental embryonic tissues, in tissues undergoing morphogenetic transition and in mature weight-bearing tissues.
James Melrose, Anthony J Hayes
exaly   +5 more sources

The role of aggrecan in normal and osteoarthritic cartilage [PDF]

Journal of Experimental Orthopaedics, 2014
Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
John S Mort, Peter J Roughley
exaly   +4 more sources

Aggrecan

Bolʹ, Sustavy, Pozvonočnik, 2012
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N.V. Dedukh
doaj   +2 more sources

Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways

Bone & Joint Research, 2023
Aims: Osteoarthritis (OA) is a prevalent joint disorder with inflammatory response and cartilage deterioration as its main features. Dihydrocaffeic acid (DHCA), a bioactive component extracted from natural plant (gynura bicolor), has demonstrated anti ...
Rui Lu, Ying-Guang Wang, Yunkun Qu, Shan-Xi Wang, Cheng Peng, Hongbo You, Wentao Zhu, Anmin Chen   +7 more
doaj   +1 more source

Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity

Cell Death and Disease, 2022
Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from articular cartilage followed by degeneration of the tissue.
Roman J. Krawetz, Yiru Elizabeth Wu, Karri L. Bertram, Anchita Shonak, Anand O. Masson, Guomin Ren, Catherine Leonard, Mohit Kapoor, John R. Matyas, Paul T. Salo   +9 more
doaj   +1 more source

A nuclear magnetic resonance study of water in aggrecan solutions [PDF]

Royal Society Open Science, 2016
Aggrecan, a highly charged macromolecule found in articular cartilage, was investigated in aqueous salt solutions with proton nuclear magnetic resonance. The longitudinal and transverse relaxation rates were determined at two different field strengths, 9.
Richard J. Foster, Robin A. Damion, Thomas G. Baboolal, Stephen W. Smye, Michael E. Ries   +4 more
doaj   +1 more source

Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix

Frontiers in Bioengineering and Biotechnology, 2023
Aggrecan (ACAN) is localized in the intervertebral disc (IVD) in unique compartment-specific patterns where it contributes to the tissue structure and mechanical function together with collagens.
Marta Empere, Marta Empere, Xujia Wang, Carina Prein, Carina Prein, Anders Aspberg, Markus Moser, Markus Moser, Toshitaka Oohashi, Hauke Clausen-Schaumann, Attila Aszodi, Attila Aszodi, Paolo Alberton, Paolo Alberton   +13 more
doaj   +1 more source

Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors

Bone & Joint Research, 2023
Aims: This study was performed to explore the effect of melatonin on pyroptosis in nucleus pulposus cells (NPCs) and the underlying mechanism of that effect.
Zhibiao Bai, Zeyu Shou, Kai Hu, Jiahuan Yu, Hongming Meng, Chun Chen   +5 more
doaj   +1 more source

Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity

Antioxidants, 2023
Atherosclerosis is a chronic inflammatory disease and a leading cause of mortality. It is characterized by arterial wall plaques that contain high levels of cholesterol and other lipids and activated leukocytes covered by a fibrous cap of extracellular ...
Yihe Wang, Astrid Hammer, Gerald Hoefler, Ernst Malle, Clare L. Hawkins, Christine Y. Chuang, Michael J. Davies   +6 more
doaj   +1 more source

Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex

IBRO Reports, 2018
Specific regions of the cerebral cortex are highly plastic in an organism’s lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed
Hiroshi Ueno, Kazuki Fujii, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Shozo Aoki, Motoi Okamoto, Takeshi Ishihara, Keizo Takao   +9 more
doaj   +1 more source