Results 1 to 10 of about 21,330 (209)

The role of aggrecan in normal and osteoarthritic cartilage [PDF]

Journal of Experimental Orthopaedics, 2014
Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
Peter Roughley, John S Mort, Roughley Peter J   +2 more
exaly   +4 more sources

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis [PDF]

JOR Spine
The intervertebral disc (IVD) is a tough fibrocartilaginous viscoelastic cushion interposed between spinal vertebrae. It has a composite structure whose material properties are due to the interplay between fibrillar collagens which, provide high tensile ...
James Melrose
doaj   +2 more sources

Proteoglycans as Biomarkers of Medial Degeneration in Acute Stanford Type A Aortic Dissection [PDF]

Reviews in Cardiovascular Medicine
Acute Stanford type A aortic dissection (ATAAD) is a life-threatening cardiovascular emergency that demands prompt and accurate diagnosis due to a high associated mortality. Although imaging remains the diagnostic gold standard, the limited accessibility
Ghufran Bagaber, Wenyu Song, Guangguo Fu, Kui Hu, Zhe Wang, Yubin Hu, Lai Wei, Jinmiao Chen   +7 more
doaj   +2 more sources

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity

Biomolecules, 2020
This review examines aggrecan’s roles in developmental embryonic tissues, in tissues undergoing morphogenetic transition and in mature weight-bearing tissues.
Anthony J Hayes, James Melrose, Hayes Anthony J   +2 more
exaly   +3 more sources

Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content. [PDF]

PLoS Computational Biology
Degenerative musculoskeletal diseases like osteoarthritis can be initiated by joint injury. Injurious overloading-induced mechanical straining of articular cartilage and subsequent biological responses may trigger cartilage degradation. One early sign of
Atte S A Eskelinen, Joonas P Kosonen, Moustafa Hamada, Amir Esrafilian, Cristina Florea, Alan J Grodzinsky, Petri Tanska, Rami K Korhonen   +7 more
doaj   +2 more sources

Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways

Bone & Joint Research, 2023
Aims: Osteoarthritis (OA) is a prevalent joint disorder with inflammatory response and cartilage deterioration as its main features. Dihydrocaffeic acid (DHCA), a bioactive component extracted from natural plant (gynura bicolor), has demonstrated anti ...
Rui Lu, Ying-Guang Wang, Yunkun Qu, Shan-Xi Wang, Cheng Peng, Hongbo You, Wentao Zhu, Anmin Chen   +7 more
doaj   +1 more source

Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity

Cell Death and Disease, 2022
Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from articular cartilage followed by degeneration of the tissue.
Roman J. Krawetz, Yiru Elizabeth Wu, Karri L. Bertram, Anchita Shonak, Anand O. Masson, Guomin Ren, Catherine Leonard, Mohit Kapoor, John R. Matyas, Paul T. Salo   +9 more
doaj   +1 more source

A nuclear magnetic resonance study of water in aggrecan solutions [PDF]

Royal Society Open Science, 2016
Aggrecan, a highly charged macromolecule found in articular cartilage, was investigated in aqueous salt solutions with proton nuclear magnetic resonance. The longitudinal and transverse relaxation rates were determined at two different field strengths, 9.
Richard J. Foster, Robin A. Damion, Thomas G. Baboolal, Stephen W. Smye, Michael E. Ries   +4 more
doaj   +1 more source

Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix

Frontiers in Bioengineering and Biotechnology, 2023
Aggrecan (ACAN) is localized in the intervertebral disc (IVD) in unique compartment-specific patterns where it contributes to the tissue structure and mechanical function together with collagens.
Marta Empere, Marta Empere, Xujia Wang, Carina Prein, Carina Prein, Anders Aspberg, Markus Moser, Markus Moser, Toshitaka Oohashi, Hauke Clausen-Schaumann, Attila Aszodi, Attila Aszodi, Paolo Alberton, Paolo Alberton   +13 more
doaj   +1 more source

Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors

Bone & Joint Research, 2023
Aims: This study was performed to explore the effect of melatonin on pyroptosis in nucleus pulposus cells (NPCs) and the underlying mechanism of that effect.
Zhibiao Bai, Zeyu Shou, Kai Hu, Jiahuan Yu, Hongming Meng, Chun Chen   +5 more
doaj   +1 more source