The role of aggrecan in normal and osteoarthritic cartilage [PDF]
Journal of Experimental Orthopaedics, 2014 Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.
John S Mort
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Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity [PDF]
Arthritis Research & Therapy, 2017 Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues.
Per Swärd +5 more
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Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis [PDF]
JOR SpineThe intervertebral disc (IVD) is a tough fibrocartilaginous viscoelastic cushion interposed between spinal vertebrae. It has a composite structure whose material properties are due to the interplay between fibrillar collagens which, provide high tensile ...
James Melrose
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Proteoglycans as Biomarkers of Medial Degeneration in Acute Stanford Type A Aortic Dissection [PDF]
Reviews in Cardiovascular MedicineAcute Stanford type A aortic dissection (ATAAD) is a life-threatening cardiovascular emergency that demands prompt and accurate diagnosis due to a high associated mortality. Although imaging remains the diagnostic gold standard, the limited accessibility
Ghufran Bagaber +7 more
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A nuclear magnetic resonance study of water in aggrecan solutions [PDF]
Royal Society Open Science, 2016 Aggrecan, a highly charged macromolecule found in articular cartilage, was investigated in aqueous salt solutions with proton nuclear magnetic resonance. The longitudinal and transverse relaxation rates were determined at two different field strengths, 9.
Richard J. Foster +4 more
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Biomolecules, 2020 This review examines aggrecan’s roles in developmental embryonic tissues, in tissues undergoing morphogenetic transition and in mature weight-bearing tissues.
Anthony J Hayes, James Melrose
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Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content. [PDF]
PLoS Computational BiologyDegenerative musculoskeletal diseases like osteoarthritis can be initiated by joint injury. Injurious overloading-induced mechanical straining of articular cartilage and subsequent biological responses may trigger cartilage degradation. One early sign of
Atte S A Eskelinen +7 more
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Self-Consistent Field Modeling of Bottle-Brush with Aggrecan-like Side Chain [PDF]
BiomimeticsBottle-brush polymers with aggrecan-like side chains represent a class of biomimetic macromolecules that replicate key structural and functional features of natural complexes of aggrecans with hyaluronic acid (HA) which are the major components of ...
Ivan V. Mikhailov +3 more
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Bone & Joint Research, 2023 Aims: Osteoarthritis (OA) is a prevalent joint disorder with inflammatory response and cartilage deterioration as its main features. Dihydrocaffeic acid (DHCA), a bioactive component extracted from natural plant (gynura bicolor), has demonstrated anti ...
Rui Lu +7 more
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Cell Death and Disease, 2022 Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from articular cartilage followed by degeneration of the tissue.
Roman J. Krawetz +9 more
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