Results 1 to 10 of about 23,456 (158)

Revisiting intervertebral disc degeneration: lipid metabolism disorders as overlooked contributors to complex pathology [PDF]

Frontiers in Immunology
With the global population aging, intervertebral disc degeneration (IDD), an aging-related disease, has been confirmed to be an important cause of low back pain (LBP).
Shuang Chen, Shuang Chen, Hongshan Liu, Kaizhong Wang, Kaizhong Wang, Hui Wang, Hui Wang, Anqiao Xu, Moran Suo, Moran Suo, Xin Chen, Xin Chen, Zhonghai Li, Zhonghai Li   +13 more
doaj   +2 more sources

Pathomechanism of intervertebral disc degeneration

JOR Spine, 2020
AbstractIntervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a leading cause of disability worldwide. Although substantial progress has been made in elucidating the molecular mechanisms of IDD, fundamental and long‐lasting treatments for IDD are still lacking.
Sakae Tanaka, Takeshi Oichi
exaly   +4 more sources

Genetic Therapy for Intervertebral Disc Degeneration [PDF]

International Journal of Molecular Sciences, 2021
Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to disability. Despite significant advances in the treatment of discogenic LBP, the limitations of current treatments have sparked interest in biological approaches, including growth factor and stem cell injection, as new treatment options for patients with chronic ...
Kyoung In Kim, Inbo Han, Kyoung-Tae Kim   +2 more
exaly   +3 more sources

Notochord Cells in Intervertebral Disc Development and Degeneration

Journal of Developmental Biology, 2016
The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion, and load transmission throughout the spine. Importantly, degeneration of the intervertebral disc is thought to be an initiating factor for back pain. Due to a
Cheryle Seguin, Matthew Mccann, Seguin Cheryle A   +2 more
exaly   +3 more sources

Role of macrophage in intervertebral disc degeneration

Bone Research
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang   +6 more
doaj   +3 more sources

Lactate and lactylation in intervertebral disc degeneration. [PDF]

Front Mol Biosci
The unique hypoxic microenvironment of the intervertebral disc, characterized by its avascularity and restricted nutrient exchange, drives a shift in cellular metabolism towards anaerobic glycolysis. This metabolic adaptation results in the accumulation of significant lactate levels.
Liu Y, Yang J, Wang Z, Fu J, Liu H, Lu Z, Dong J, Li Z, Mao Q, Li C, Ma H.   +10 more
europepmc   +3 more sources

Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats

Frontiers in Pharmacology, 2023
Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress.
Yan Chen, Yan Chen, Baixing Li, Baixing Li, Yue Xu, Tangjun Zhou, Tangjun Zhou, Changqing Zhao, Changqing Zhao, Jie Zhao, Jie Zhao   +10 more
doaj   +1 more source

Treatment of Intervertebral Disc Degeneration

Orthopaedic Surgery, 2022
Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs. IDD results from many factors, including genetic factors, aging, mechanical injury, malnutrition, and so on.
Jingguo Xin, Yongjie Wang, Zhi Zheng, Shuo Wang, Shibo Na, Shaokun Zhang   +5 more
openaire   +3 more sources

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2021
Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
doaj   +1 more source

The role of ageing and oxidative stress in intervertebral disc degeneration

Frontiers in Molecular Biosciences, 2022
Intervertebral disc degeneration (IDD) is the primary cause of intervertebral disc (IVD) disease. With the increased ageing of society, an increasing number of patients are plagued by intervertebral disc disease. Ageing not only accelerates the decreased
Pengfei Wen, Bolong Zheng, Binfei Zhang, Tao Ma, Linjie Hao, Yumin Zhang   +5 more
doaj   +1 more source