Results 1 to 10 of about 39,314 (264)

Notochord Cells in Intervertebral Disc Development and Degeneration

Journal of Developmental Biology, 2016
The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion, and load transmission throughout the spine. Importantly, degeneration of the intervertebral disc is thought to be an initiating factor for back pain. Due to a
Matthew R. McCann, Cheryle A. Séguin
doaj   +3 more sources

Role of macrophage in intervertebral disc degeneration

Bone Research
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang   +6 more
doaj   +3 more sources

Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats

Frontiers in Pharmacology, 2023
Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress.
Yan Chen, Yan Chen, Baixing Li, Baixing Li, Yue Xu, Tangjun Zhou, Tangjun Zhou, Changqing Zhao, Changqing Zhao, Jie Zhao, Jie Zhao   +10 more
doaj   +1 more source

The role of ageing and oxidative stress in intervertebral disc degeneration

Frontiers in Molecular Biosciences, 2022
Intervertebral disc degeneration (IDD) is the primary cause of intervertebral disc (IVD) disease. With the increased ageing of society, an increasing number of patients are plagued by intervertebral disc disease. Ageing not only accelerates the decreased
Pengfei Wen, Bolong Zheng, Binfei Zhang, Tao Ma, Linjie Hao, Yumin Zhang   +5 more
doaj   +1 more source

Treatment of Intervertebral Disc Degeneration

Orthopaedic Surgery, 2022
Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs. IDD results from many factors, including genetic factors, aging, mechanical injury, malnutrition, and so on.
Jingguo Xin, Yongjie Wang, Zhi Zheng, Shuo Wang, Shibo Na, Shaokun Zhang   +5 more
openaire   +3 more sources

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2021
Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
doaj   +1 more source

Application study of 3D LAVA-Flex on lumbar intervertebral disc degeneration

European Journal of Medical Research, 2021
Background Degeneration of the intervertebral discs are very common diseases, indicating the specific or malignant changes in intervertebral disc component, structure and function.
Tiefang Liu, Yonghao Wang, Zhengyang Xu, Tao Wu, Xiao Zang, Meng Li, Jinfeng Li   +6 more
doaj   +1 more source

Macrophages and Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2023
The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individuals. Increasing evidence suggests that IVD degeneration
Jinsha Koroth, Erick O. Buko, Rebecca Abbott, Casey P. Johnson, Brenda M. Ogle, Laura S. Stone, Arin M. Ellingson, Elizabeth W. Bradley   +7 more
openaire   +2 more sources

Lactate and lactylation in intervertebral disc degeneration. [PDF]

Front Mol Biosci
The unique hypoxic microenvironment of the intervertebral disc, characterized by its avascularity and restricted nutrient exchange, drives a shift in cellular metabolism towards anaerobic glycolysis. This metabolic adaptation results in the accumulation of significant lactate levels.
Liu Y, Yang J, Wang Z, Fu J, Liu H, Lu Z, Dong J, Li Z, Mao Q, Li C, Ma H.   +10 more
europepmc   +3 more sources

Genetic Therapy for Intervertebral Disc Degeneration [PDF]

International Journal of Molecular Sciences, 2021
Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to disability. Despite significant advances in the treatment of discogenic LBP, the limitations of current treatments have sparked interest in biological approaches, including growth factor and stem cell injection, as new treatment options for patients with chronic ...
Eun Roh, Anjani Darai, Jae Kyung, Hyemin Choi, Su Kwon, Basanta Bhujel, Kyoung Kim, Inbo Han   +7 more
openaire   +2 more sources