Results 1 to 10 of about 413,430 (258)

Pathomechanism of intervertebral disc degeneration

JOR Spine, 2020
AbstractIntervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a leading cause of disability worldwide. Although substantial progress has been made in elucidating the molecular mechanisms of IDD, fundamental and long‐lasting treatments for IDD are still lacking.
Sakae Tanaka, Takeshi Oichi
exaly   +4 more sources

Genetic Therapy for Intervertebral Disc Degeneration [PDF]

International Journal of Molecular Sciences, 2021
Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to disability. Despite significant advances in the treatment of discogenic LBP, the limitations of current treatments have sparked interest in biological approaches, including growth factor and stem cell injection, as new treatment options for patients with chronic ...
Inbo Han, Kyoung-Tae Kim, Anjani Darai   +2 more
exaly   +3 more sources

Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration

Veterinary Journal, 2013
Intervertebral disc (IVD) degeneration is common in dogs and can give rise to a number of diseases, such as IVD herniation, cervical spondylomyelopathy, and degenerative lumbosacral stenosis. Although there have been many reports and reviews on the clinical aspects of canine IVD disease, few reports have discussed and reviewed the process of IVD ...
Guy Grinwis, Marianna Tryfonidou, Lucas Smolders   +2 more
exaly   +3 more sources

Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications

Journal of Inflammation Research, 2022
Hongfeng Ruan, Yuying Ge, Fangda Fu
exaly  

Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy

Cells, 2022
Qiaochu Li
exaly  

Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration

Osteoarthritis and Cartilage, 2021
Naifeng Tian, Yaosen Wu, Xiang-Yang Wang   +2 more
exaly  

The Role of Polymorphisms in Collagen-Encoding Genes in Intervertebral Disc Degeneration

Biomolecules, 2021
German V Medvedev, Natalia Shnayder
exaly  

Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study

Osteoarthritis and Cartilage, 2014
Noriko Yoshimura, Hiroshi Hashizume, S Muraki   +2 more
exaly  

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis

Osteoarthritis and Cartilage, 2021
exaly  

A validated new histological classification for intervertebral disc degeneration

Osteoarthritis and Cartilage, 2013
Fc Oner, L B Creemers, L B Creemers
exaly