Results 1 to 10 of about 43,248 (263)

The role of ageing and oxidative stress in intervertebral disc degeneration

Frontiers in Molecular Biosciences, 2022
Intervertebral disc degeneration (IDD) is the primary cause of intervertebral disc (IVD) disease. With the increased ageing of society, an increasing number of patients are plagued by intervertebral disc disease. Ageing not only accelerates the decreased
Wen Pengfei, Zhang Yumin
exaly   +3 more sources

Revisiting intervertebral disc degeneration: lipid metabolism disorders as overlooked contributors to complex pathology [PDF]

Frontiers in Immunology
With the global population aging, intervertebral disc degeneration (IDD), an aging-related disease, has been confirmed to be an important cause of low back pain (LBP).
Shuang Chen, Shuang Chen, Hongshan Liu, Kaizhong Wang, Kaizhong Wang, Hui Wang, Hui Wang, Anqiao Xu, Moran Suo, Moran Suo, Xin Chen, Xin Chen, Zhonghai Li, Zhonghai Li   +13 more
doaj   +2 more sources

Application study of 3D LAVA-Flex on lumbar intervertebral disc degeneration

European Journal of Medical Research, 2021
Background Degeneration of the intervertebral discs are very common diseases, indicating the specific or malignant changes in intervertebral disc component, structure and function.
Tiefang Liu, Yonghao Wang, Zhengyang Xu, Tao Wu, Xiao Zang, Meng Li, Jinfeng Li   +6 more
doaj   +1 more source

Inhibition of lysyl oxidase accelerates intervertebral disc degeneration induced by apoptosis of nucleus pulposus cells

陆军军医大学学报, 2023
Objective To explore the role and possible mechanism of lysyl oxidase (LOX) in age-related degeneration of intervertebral disc. Methods Six SD rats, aged of 2, 8 and 20 months respectively, were subjected, and then underwent intervertebral disc MRI and X-
LI Jianmin, XING Hui, CHONG Fanli, ZHAO Runzhi   +3 more
doaj   +1 more source

Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats

Frontiers in Pharmacology, 2023
Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress.
Yan Chen, Yan Chen, Baixing Li, Baixing Li, Yue Xu, Tangjun Zhou, Tangjun Zhou, Changqing Zhao, Changqing Zhao, Jie Zhao, Jie Zhao   +10 more
doaj   +1 more source

HISTOLOGICAL AND STRUCTURAL STUDY OF PROLAPSED INTERVERTEBRAL DISC [PDF]

Basrah Journal of Surgery, 2006
The research of the etiology of low back pain and right leg pain has been focused on the study of histological degenerative changes of human intervertebral disc prolapse.
Khalida K Jbara, Thamer A Hamdan
doaj   +1 more source

Pressure distributions inside intervertebral discs under unilateral pedicle screw fixation in a porcine spine model

Journal of Orthopaedic Surgery and Research, 2018
Background Little data are available regarding the effects of pedicle screws on the intervertebral disc stress for different spinal segments. The aim of this study was to analyze the intervertebral disc stress in response to the placement of pedicle ...
Zhao Meng, Chen Wang, Li-Jun Tian, Xue-Jun Zhang, Dong Guo, Yan Zou   +5 more
doaj   +1 more source

Effect of sIL-13Rα2-Fc on the progression of rat tail intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2019
Background The incidence of degenerative disc disease caused by intervertebral disc injury is increasing annually, seriously affecting the quality of life of patients and increasing the disease burden on society.
Xin Wang, Junhao Sun, Jianshi Tan, Pengzhong Fang, Jinlei Chen, Wen Yuan, Huajiang Chen, Yang Liu   +7 more
doaj   +1 more source

Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration

Journal of Orthopaedic Surgery and Research, 2021
Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
doaj   +1 more source

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis

Journal of Pharmacological Sciences, 2018
Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration.
Zeyu Sun, Yuekui Jian, Hongying Fu, Bo Li   +3 more
doaj   +1 more source