Results 31 to 40 of about 43,436 (258)

Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton

Frontiers in Endocrinology
Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeostasis through the “gut-bone axis,”
Yanlong Gong, Xin Ma, Lele Wang, Pengwei Zhang, Tingting Liu, Yuanzhen Li, Wantao Dong   +6 more
doaj   +1 more source

Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration

Frontiers in Pharmacology, 2022
Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain.
Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu, Haipeng Xue, Haipeng Xue   +5 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Development of a deep learning model for automatic detection of narrowed intervertebral disc space sites in caudal thoracic and lumbar lateral X-ray images of dogs

Frontiers in Veterinary Science
Intervertebral disc disease is the most common spinal cord-related disease in dogs, caused by disc material protrusion or extrusion that compresses the spinal cord, leading to clinical symptoms.
Junseol Park, Junseol Park, Hyunwoo Cho, Yewon Ji, Kichang Lee, Hakyoung Yoon, Hakyoung Yoon   +6 more
doaj   +1 more source

Research progress on macrophage polarization during the degeneration process of lumbar intervertebral discs [PDF]

Jichu yixue yu linchuang
During pathological progression of lumbar intervertebral disc degeneration (LIDD), macrophage polarization functions as a critical regulatory mechanism through the dynamic transition between M1 and M2 phenotypes.
CHEN Wang, LI Xugui, LI Ying
doaj   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Role of macrophage in intervertebral disc degeneration

Bone Research
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang   +6 more
doaj   +1 more source

Methanolysis of the Intervertebral Disc

Clinical Chemistry, 1967
Abstract Methanolysis of intervertebral disc samples at 60° was largely hydrolysis as shown by the absence of methylated derivatives on chromatograms of the reaction products. Extent of the reaction increased with acid strength; the products were the same.
D, Chan, E W, Hull, M, Fields, E, McNall
openaire   +2 more sources

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Neuroregulatory Biomaterials for Intervertebral Disc Regeneration via Neuro-Disc Microenvironment Modulation

Research
Intervertebral discs have long been considered to lack neural innervation. However, recent studies have revealed that intervertebral disc degeneration is accompanied by marked pathological nerve invasion.
Ang Li, Xiaohu Li, Yi Yu, Liang Chen, Juan Wang, Wenguo Cui, Xiaodong Liu   +6 more
doaj   +1 more source